Accumulation of Glucosylceramides in Multidrug-resistant Cancer Cells

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Glycosphingolipids in Cellular Interaction, Differentiation, and Oncogenesis

1981 • 1,650 citations

Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation

1989 • 1,251 citations

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1991 • 1,094 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

Mechanism of multidrug resistance

1988 • 630 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Tumor Necrosis Factor-α Activates the Sphingomyelin Signal Transduction Pathway in a Cell-Free System

1992 • 428 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Biochemistry of lipids and membranes

1986 • 332 citations

Accumulation of Glucosylceramide and Glucosylsphingosine (Psychosine) in Cerebrum and Cerebellum in Infantile and Juvenile Gaucher Disease

1982 • 271 citations

Localization of the gangliosides GD2 and GD3 in adhesion plaques and on the surface of human melanoma cells.

1984 • 198 citations

P-glycoprotein, multidrug resistance and tumor progression

1994 • 194 citations

Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons

1993 • 181 citations

Regulation of Ion Channels by ABC Transporters That Secrete ATP

1995 • 174 citations

Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase

1995 • 165 citations

A Regulatory Role for Sphingolipids in Neuronal Growth

1995 • 157 citations

Improved Inhibitors of Glucosylceramide Synthase1

1992 • 149 citations

Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).

1986 • 145 citations

Acid β-Glucosidase: Enzymology and Molecular Biology of Gaucher Diseas

1990 • 141 citations

Sphingomyelinase and cell-permeable ceramide analogs stimulate cellular proliferation in quiescent Swiss 3T3 fibroblasts.

1992 • 128 citations

Regulation of Lipid Biosynthesis in Saccharomyces cerevisiae by Fumonisin B1

1995 • 111 citations

Inhibition of Sphingolipid Synthesis by Cycloserine In Vitro and In Vivo

1984 • 110 citations

Drug resistance in Chinese hamster lung and mouse tumor cells.

1983 • 105 citations

Expression of resistance factors (P-glycoprotein, glutathione S-transferase-π, and topoisomerase II) and their interrelationship to proto-oncogene products in renal cell carcinomas

1993 • 93 citations

GD2 ganglioside biosynthesis is a distinct biochemical event in human melanoma tumor progression

1986 • 80 citations

Dual Roles of Sphingolipids in Signaling of the Escape from and Onset of Apoptosis in a Mouse Cytotoxic T-cell Line, CTLL-2

1996 • 74 citations

Sphingolipid Biosynthesis Is Necessary for Dendrite Growth and Survival of Cerebellar Purkinje Cells in Culture

1995 • 73 citations

A ganglioside of rat ascites hepatoma AH 7974F cells. Occurrence of a novel disialoganglioside (GD1 alpha) with a unique N-acetylneuraminosyl (alpha 2-6)-N-acetylgalactosamine structure.

1986 • 70 citations

P-glycoprotein. ATP hydrolysis by the N-terminal nucleotide-binding domain.

1992 • 69 citations

Differences in lipid composition of doxorubicin-sensitive and -resistant P388 cells.

1984 • 62 citations

3′-Azidothymidine (Zidovudine) Inhibits Glycosylation and Dramatically Alters Glycosphingolipid Synthesis in Whole Cells at Clinically Relevant Concentrations

1995 • 57 citations

Structure of a novel sialylated fucosyl lacto-N-norhexaosylceramide isolated from chronic myelogenous leukemia cells.

1986 • 50 citations

Chapter 19 Tumor gangliosides as targets for active specific immunotherapy of melanoma in man

1994 • 41 citations

Improved synthesis of conduritol B epoxide

1985 • 29 citations

Characterization of cellular lipids in doxorubicin-sensitive and -resistant P388 mouse leukemia cells

1986 • 22 citations

Increased Phospholipase D Activity in Multidrug-Resistant Breast Cancer Cells

1994 • 19 citations

Induction of multidrug resistance (MDR) by transfection of MCF‐10A cell line with c‐Ha‐ras and c‐erbB‐2 oncogenes

1994 • 18 citations

Accumulation of Fatty Alcohol in MCF-7 Breast Cancer Cells

1994 • 16 citations

Decreased formation of inositol trisphosphate in Madin-Darby canine kidney cells under conditions of β-glucosidase inhibition

1992 • 10 citations