Importance of C1B Domain for Lipid Messenger-induced Targeting of Protein Kinase C

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Functions of Ceramide in Coordinating Cellular Responses to Stress

1996 • 1,620 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins

1998 • 1,094 citations

Regulation of protein kinase C

1997 • 919 citations

Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus

1989 • 612 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence.

1989 • 439 citations

A Protein Kinase C Translocation Inhibitor as an Isozyme-selective Antagonist of Cardiac Function

1996 • 371 citations

Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation

1992 • 354 citations

Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.

1993 • 352 citations

A new member of the protein kinase C family, nPKC theta, predominantly expressed in skeletal muscle.

1992 • 340 citations

Green Fluorescent Protein (GFP)-tagged Cysteine-rich Domains from Protein Kinase C as Fluorescent Indicators for Diacylglycerol Signaling in Living Cells

1998 • 331 citations

Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: its possible implications.

1991 • 316 citations

Arachidonic Acid Causes Cell Death through the Mitochondrial Permeability Transition

2001 • 284 citations

A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

1994 • 236 citations

Arachidonic Acid and Phosphorylation Synergistically Induce a Conformational Change of p47 to Activate the Phagocyte NADPH Oxidase

2000 • 235 citations

Ceramide Signaling Downstream of the p75 Neurotrophin Receptor Mediates the Effects of Nerve Growth Factor on Outgrowth of Cultured Hippocampal Neurons

1999 • 192 citations

Protein Kinase C: Seeing two domains

1995 • 186 citations

Ceramide-induced Translocation of Protein Kinase C-δ and -ϵ to the Cytosol

1997 • 178 citations

Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed Mutagenesis

1995 • 149 citations

Distinct Effects of Fatty Acids on Translocation of γ- and ε-Subspecies of Protein Kinase C

1998 • 137 citations

Molecular Basis for Protein Kinase C Isozyme-Selective Binding: The Synthesis, Folding, and Phorbol Ester Binding of the Cysteine-Rich Domains of All Protein Kinase C Isozymes

1998 • 136 citations

Three Distinct Mechanisms for Translocation and Activation of the δ Subspecies of Protein Kinase C

1998 • 135 citations

Roles of Ionic Residues of the C1 Domain in Protein Kinase C-α Activation and the Origin of Phosphatidylserine Specificity

2001 • 121 citations

Molecular Analysis of the Interactions between Protein Kinase C-ε and Filamentous Actin

1998 • 120 citations

Cellular and intracellular localization of ε-subspecies of protein kinase C in the rat brain; presynaptic localization of the ε-subspecies

1993 • 117 citations

Selective Ceramide Binding to Protein Kinase C-α and -δ Isoenzymes in Renal Mesangial Cells

1998 • 116 citations

An Inhibitory Fragment Derived from Protein Kinase Cε Prevents Enhancement of Nerve Growth Factor Responses by Ethanol and Phorbol Esters

1997 • 102 citations

Arachidonic acid stimulates protein kinase C-ε redistribution in heart cells

1997 • 101 citations

Subtype-Specific Translocation of the δ Subtype of Protein Kinase C and Its Activation by Tyrosine Phosphorylation Induced by Ceramide in HeLa Cells

2001 • 100 citations

Interactions between Protein Kinase C and Pleckstrin Homology Domains

1997 • 97 citations

Nucleotide sequences of cDNAs for α and γ subspecies of rat brain protein kinase C

1988 • 85 citations

The regulatory region of protein kinase C gamma. Studies of phorbol ester binding to individual and combined functional segments expressed as glutathione S-transferase fusion proteins indicate a complex mechanism of regulation by phospholipids, phorbol esters, and divalent cations.

1994 • 84 citations

Protein Kinases C Translocation Responses to Low Concentrations of Arachidonic Acid

2001 • 65 citations

Long-term changes of synaptic transmission induced by arachidonic acid in the CA1 subfield of the rat hippocampus

1990 • 58 citations

NGF-resistant PC12 cell death induced by arachidonic acid is accompanied by a decrease of active PKC zeta and nuclear factor kappa B

1999 • 54 citations

Ceramide-induced sustained depression of synaptic currents mediated by ionotropic glutamate receptors in the hippocampus: an essential role of postsynaptic protein phosphatases

2000 • 46 citations

Distinct Effects of Saturated Fatty Acids on Protein Kinase C Subspecies1

1995 • 34 citations

Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay

1995 • 33 citations

Comparison of the roles of the C1a and C1b domains of protein kinase C alpha in ligand induced translocation in NIH 3T3 cells

1999 • 32 citations

14–3-3 Inhibits theDictyosteliumMyosin II Heavy-Chain-specific Protein Kinase C Activity by a Direct Interaction: Identification of the 14–3-3 Binding Domain

1997 • 29 citations

A long-lasting facilitation of hippocampal neurotransmission via a phospholipase A2 signaling pathway

2001 • 29 citations

Phospholipase A2 and its products are involved in the purinergic receptor-mediated translocation of protein kinase C in CHO-K1 cells

2000 • 23 citations

Activation of conventional mammalian protein kinase C isoforms expressed in budding yeast modulates the cell doubling time--a potential in vivo screen for protein kinase C activators.

1996 • 11 citations

Arachidonic acid and prostaglandin D2 cooperatively accelerate desensitization of nicotinic acetylcholine receptor channel in mouse skeletal muscles

2000 • 9 citations