Ceramide Directly Activates Protein Kinase C ζ to Regulate a Stress-activated Protein Kinase Signaling Complex

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes

1998 • 765 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 • 621 citations

PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.

1995 • 506 citations

Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.

1994 • 473 citations

MP1: A MEK Binding Partner That Enhances Enzymatic Activation of the MAP Kinase Cascade

1998 • 471 citations

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway.

1994 • 459 citations

Activation of the Sphingomyelin Signaling Pathway in Intact EL4 Cells and in a Cell-Free System By IL-1β

1993 • 433 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Ceramide Activates the Stress-activated Protein Kinases

1995 • 367 citations

Taxonomy and function of C1 protein kinase C homology domains

1997 • 350 citations

Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor alpha.

1994 • 340 citations

Fas- or Ceramide-induced Apoptosis Is Mediated by a Rac1-regulated Activation of Jun N-terminal Kinase/p38 Kinases and GADD153

1997 • 302 citations

Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A

1999 • 292 citations

Activation of the c-Raf protein kinase by protein kinase C phosphorylation.

1992 • 288 citations

Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3

2000 • 278 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization

1999 • 214 citations

Ceramide-induced Translocation of Protein Kinase C-δ and -ϵ to the Cytosol

1997 • 178 citations

Sphingosine 1-phosphate: a prototype of a new class of second messengers

1999 • 176 citations

PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase.

1996 • 153 citations

Evidence That Atypical Protein Kinase C-λ and Atypical Protein Kinase C-ζ Participate in Ras-mediated Reorganization of the F-actin Cytoskeleton

1999 • 138 citations

Atypical PKC ζ is activated by ceramide, resulting in coactivation of NF-κb/JNK kinase and cell survival

1999 • 135 citations

Selective Ceramide Binding to Protein Kinase C-α and -δ Isoenzymes in Renal Mesangial Cells

1998 • 116 citations

Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling

1998 • 112 citations

Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades

1996 • 106 citations

Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway

1998 • 98 citations

Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I.

1998 • 92 citations

N-Acylated Serinol Is a Novel Ceramide Mimic Inducing Apoptosis in Neuroblastoma Cells

2000 • 89 citations

A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells

1997 • 73 citations

Activation of Protein Kinase C-ζ and Phosphatidylinositol 3′-Kinase and Promotion of Macrophage Differentiation by Insulin-Like Growth Factor-I

1998 • 69 citations

Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells

1999 • 56 citations

Arachidonic acid induces the activation of the stress‐activated protein kinase, membrane ruffling and H₂O₂ production via a small GTPase Rac1

1999 • 52 citations

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells.

1996 • 43 citations

Ceramide‐induced translocation of protein kinase C ζ in primary cultures of astrocytes

1997 • 40 citations

Interleukin-1-induced Ether-linked Diglycerides Inhibit Calcium-insensitive Protein Kinase C Isotypes

1997 • 32 citations

Interleukin-1 and Endothelin Stimulate Distinct Species of Diglycerides That Differentially Regulate Protein Kinase C in Mesangial Cells

1995 • 31 citations

Overexpression of PKC zeta in NIH3T3 cells does not induce cell transformation nor tumorigenicity and does not alter NF kappa B activity.

1995 • 21 citations

PKC α regulates thrombin‐induced PDGF‐B chain gene expression in mesangial cells

1995 • 19 citations