Ceramide as an Activator Lipid of Cathepsin D

TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown

1992 • 1,058 citations

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

1996 • 795 citations

Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling

1994 • 726 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

High-titer packaging cells producing recombinant retroviruses resistant to human serum

1995 • 672 citations

Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.

1994 • 582 citations

Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha.

1996 • 467 citations

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells.

1995 • 428 citations

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

1997 • 406 citations

FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase

1996 • 390 citations

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

1999 • 361 citations

Compartmentalized Production of Ceramide at the Cell Surface

1995 • 352 citations

Cloning and sequence analysis of cDNA for human cathepsin D.

1985 • 318 citations

The role of ceramide in cell signaling

1998 • 312 citations

Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis

1997 • 286 citations

Biosynthesis and transport of cathepsin D in cultured human fibroblasts.

1983 • 235 citations

Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity

1998 • 229 citations

Inhibition of Receptor Internalization by Monodansylcadaverine Selectively Blocks p55 Tumor Necrosis Factor Receptor Death Domain Signaling

1999 • 199 citations

Purification and Characterization of Human Cleavage Factor Im Involved in the 3′ End Processing of Messenger RNA Precursors

1996 • 195 citations

TNF Receptor Death Domain-associated Proteins TRADD and FADD Signal Activation of Acid Sphingomyelinase

1998 • 171 citations

Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells

1998 • 150 citations

Cleavage of Parathyroid Hormone in Macrophage Endosomes Illustrates a Novel Pathway for Intracellular Processing of Proteins

1989 • 131 citations

Participation of Cathepsins B and D in Apoptosis of PC12 Cells Following Serum Deprivation

1998 • 118 citations

Role of an acidic compartment in tumor‐necrosis‐factor‐α−induced production of ceramide, activation of caspase‐3 and apoptosis

1998 • 109 citations

2-(Tributylstannyl)-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl Alcohol: A Building Block for Photolabeling and Crosslinking Reagents of Very High Specific Radioactivity

1995 • 96 citations

Identification of subcellular compartments involved in biosynthetic processing of cathepsin D.

1992 • 90 citations

Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice

1999 • 76 citations

An Ultrastructural and Immunohistochemical Study of PC12 Cells During Apoptosis Induced by Serum Deprivation with Special Reference to Autophagy and Lysosomal Cathepsins.

1998 • 71 citations

Requirement of FADD for Tumor Necrosis Factor-induced Activation of Acid Sphingomyelinase

1999 • 58 citations

Self-activation of Recombinant Human Lysosomal Procathepsin D at a Newly Engineered Cleavage Junction, “Short” Pseudocathepsin D

1996 • 54 citations

Turnover of endogenous ceramide in cultured normal and Farber fibroblasts

1997 • 31 citations

The mode of ceramide action: The alkyl chain protrusion model

1997 • 17 citations

Identification of intracellular ceramide target proteins by affinity chromatography and TID-ceramide photoaffinity labelling

1999 • 8 citations

Use of Affinity Chromatography and TID-Ceramide Photoaffinity Labeling for Detection of Ceramide-Binding Proteins

2000 • 4 citations