N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase.

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.

1996 • 371 citations

Targeting Ceramide Metabolism--a Strategy for Overcoming Drug Resistance

2001 • 317 citations

Agents that Reverse Multidrug Resistance, Tamoxifen, Verapamil, and Cyclosporin A, Block Glycosphingolipid Metabolism by Inhibiting Ceramide Glycosylation in Human Cancer Cells

1997 • 290 citations

Increase of Ceramide and Induction of Mixed Apoptosis/Necrosis by N-(4-Hydroxyphenyl)- retinamide in Neuroblastoma Cell Lines

1999 • 289 citations

Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis

2000 • 283 citations

Expression of Glucosylceramide Synthase, Converting Ceramide to Glucosylceramide, Confers Adriamycin Resistance in Human Breast Cancer Cells

1999 • 269 citations

Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-Hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism

2000 • 219 citations

Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy.

1998 • 184 citations

Taxol-induced ceramide generation and apoptosis in human breast cancer cells

2001 • 136 citations

Uncoupling Ceramide Glycosylation by Transfection of Glucosylceramide Synthase Antisense Reverses Adriamycin Resistance

2000 • 127 citations

Tumor Necrosis Factor Induces Ceramide Oscillations and Negatively Controls Sphingolipid Synthases by Caspases in Apoptotic Kym-1 Cells

1998 • 100 citations

Production of Ceramides Causes Apoptosis during Early Neural Differentiation in Vitro

2000 • 95 citations

Multidrug resistance modulators and doxorubicin synergize to elevate ceramide levels and elicit apoptosis in drug-resistant cancer cells

1999 • 84 citations

Serine-palmitoyl transferase activity in cultured human keratinocytes

1990 • 77 citations

Glycosylation of Ceramide Potentiates Cellular Resistance to Tumor Necrosis Factor-α-Induced Apoptosis

1999 • 71 citations

1-phenyl-2-decanoylamino-3-morpholino-1-propanol chemosensitizes neuroblastoma cells for taxol and vincristine.

2000 • 69 citations

Ceramide toxicity and metabolism differ in wild-type and multidrug-resistant cancer cells.

1999 • 47 citations

Apoptosis induced by N-hexanoylsphingosine in CHP-100 cells associates with accumulation of endogenous ceramide and is potentiated by inhibition of glucocerebroside synthesis

1998 • 44 citations

The Role of De Novo Ceramide Synthesis in Chemotherapy‐Induced Apoptosis

2000 • 44 citations

N-Oleoylethanolamine Inhibits Glucosylation of Natural Ceramides in CHP-100 Neuroepithelioma Cells: Possible Implications for Apoptosis

1999 • 27 citations

Tamoxifen elicits rapid transmembrane lipid signal responses in human breast cancer cells

1995 • 19 citations