Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

[5] Synthesis of small RNAs using T7 RNA polymerase

1989 • 1,072 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

RNA evolution and the origins of life

1989 • 629 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

Structural Domains of Transfer RNA Molecules

1976 • 529 citations

The Chemistry of Self-Splicing RNA and RNA Enzymes

1987 • 523 citations

On the origin of RNA splicing and introns

1985 • 483 citations

The generality of self-splicing RNA: Relationship to nuclear mRNA splicing

1986 • 464 citations

24 Bovine Pancreatic Ribonuclease

1971 • 437 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA

1986 • 389 citations

Enzymatic Breakage and Joining of Deoxyribonucleic Acid

1968 • 382 citations

The guanosine binding site of the Tetrahymena ribozyme

1989 • 356 citations

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.

1989 • 349 citations

Scanning from an independently specified branch point defines the 3′ splice site of mammalian introns

1989 • 267 citations

Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA

1984 • 263 citations

Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate

1984 • 262 citations

"Five Easy Pieces"

1991 • 255 citations

RNA splicing: Three themes with variations

1983 • 235 citations

Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors

1985 • 232 citations

Enzymic oligoribonucleotide synthesis with T4 RNA ligase

1978 • 220 citations

Pre-mRNA Splicing in Yeast

1989 • 209 citations

New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing

1986 • 189 citations

12 Pancreatic Ribonuclease

1982 • 178 citations

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

1990 • 167 citations

[4] Synthesis of long, capped transcripts in Vitro by SP6 and T7 RNA polymerases

1989 • 154 citations

Self-splicing group II and nuclear pre-mRNA introns: how similar are they?

1990 • 135 citations

Absolute Stereochemistry of the Second Step of Ribonuclease Action

1970 • 132 citations

DNA cleavage catalysed by the ribozyme from Tetrahymena

1990 • 130 citations

CXII. Total synthesis of the structural gene for an alanine transfer RNA from yeast. Enzymic joining of the chemically synthesized polydeoxynucleotides to form the DNA duplex representing nucleotide sequence 1 to 20

1972 • 124 citations

Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicing

1985 • 122 citations

Interaction of bacteriophage T4 RNA and DNA ligases in joining of duplex DNA at base-paired ends.

1977 • 118 citations

2 T4 RNA Ligase

1982 • 103 citations

Ribozyme inhibitors. Deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor

1986 • 101 citations

Group I Intron Self-Splicing with Adenosine: Evidence for a Single Nucleoside-Binding Site

1991 • 100 citations

The Effect of Acceptor Oligoribonucleotide Sequence on the T₄ RNA Ligase Reaction

1982 • 95 citations

Equimolar addition of oligoribonucleotides with T4 RNA ligase

1977 • 89 citations

Polynucleotide Ligase-Catalyzed Joining of Deoxyribo-oligonucleotides on Ribopolynucleotide Templates and of Ribo-oligonucleotides on Deoxyribopolynucleotide Templates

1970 • 89 citations

Dinucleoside pyrophosphate are substrates for T4-induced RNA ligase.

1977 • 78 citations

High resolution structure of the RNA duplex [U(U-A)6A]2

1988 • 78 citations

Enzymatic Breakage and Joining of Deoxyribonucleic Acid

1971 • 77 citations

[3] Joining of RNA molecules with RNA ligase

1983 • 71 citations

Chemical development in the design of oligonucleotide probes for binding to DNA and RNA

1988 • 64 citations

13 Ribonuclease T1

1982 • 62 citations

Mutations at the lariat acceptor site allow self-splicing of a group II intron without lariat formation.

1987 • 57 citations

Catalysis of splicing-related reactions between dinucleotides by a ribozyme

1987 • 56 citations

1 DNA Ligases

1982 • 52 citations

In vitrosplicing of simian virus 40 early pre mRNA

1986 • 48 citations

A computational approach to the mechanism of self-cleavage of hammerhead RNA.

1989 • 38 citations

Hydroxyl radical "footprinting" of RNA: application to pre-mRNA splicing complexes.

1989 • 36 citations

On the fidelity of phage T4-induced polynucleotide ligase in the joining of chemically synthesized deoxyribooligonucleotides

1970 • 31 citations

Specific replacement of functional groups of uridine-33 in yeast phenylalanine transfer ribonucleic acid

1985 • 23 citations

Ribonucleic acid ligase activity of deoxyribonucleic acid ligase from phage T4 infected Escherichia coli

1974 • 21 citations

Terminal cross-linking of DNA strands by a mixture of exonuclease III of Escherichia coli and polynucleotide ligase of bacteriophage T4

1976 • 12 citations