Mutational analysis of the yeast U2 snRNA suggests a structural similarity to the catalytic core of group I introns

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena

1982 • 2,241 citations

Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis

1990 • 1,239 citations

PRE-mRNA SPLICING

1986 • 673 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA

1987 • 508 citations

On the origin of RNA splicing and introns

1985 • 483 citations

Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites

1992 • 466 citations

The generality of self-splicing RNA: Relationship to nuclear mRNA splicing

1986 • 464 citations

SPLICEOSOMAL snRNAs

1988 • 463 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

Spliceosome assembly in yeast.

1987 • 402 citations

U5 snRNA interacts with exon sequences at 5′ and 3′ splice sites

1992 • 368 citations

Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

1992 • 367 citations

The guanosine binding site of the Tetrahymena ribozyme

1989 • 356 citations

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

1989 • 314 citations

Functions of the Abundant U-snRNPs

1988 • 284 citations

A compensatory base change in human U2 snRNA can suppress a branch site mutation.

1989 • 284 citations

Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA

1984 • 263 citations

Structure and function of major and minor small nuclear ribonucleoprotein particles

1989 • 242 citations

A Specific Amino Acid Binding Site Composed of RNA

1988 • 203 citations

Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles.

1988 • 183 citations

RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme

1992 • 182 citations

Multiple roles for U6 snRNA in the splicing pathway.

1990 • 179 citations

Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro

1985 • 172 citations

Base pairing between U2 and U6 snRNAs is necessary for splicing of a mammalian pre-mRNA

1991 • 172 citations

Two Domains of Yeast U6 Small Nuclear RNA Required for Both Steps of Nuclear Precursor Messenger RNA Splicing

1990 • 171 citations

Evidence for base-pairing between mammalian U2 and U6 small nuclear ribonucleoprotein particles.

1990 • 171 citations

Genetic evidence for base pairing between U2 and U6 snRNA in mammalian mRNA splicing

1991 • 165 citations

Nuclear pre‐mRNA splicing in yeast

1989 • 156 citations

Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing

1986 • 150 citations

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.

1990 • 147 citations

Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes.

1987 • 143 citations

Self-splicing group II and nuclear pre-mRNA introns: how similar are they?

1990 • 135 citations

In vitro assembly of yeast U6 snRNP: a functional assay.

1989 • 134 citations

Destruction of U2, U4, or U6 small nuclear RNA blocks Trans splicing in trypanosome cells

1990 • 131 citations

Translationsl regulation of expression of the bacteriophage T4 lysozyme gene

1986 • 122 citations

Isolation and sequence of four small nuclear U RNA genes of Trypanosoma brucei subsp. brucei: identification of the U2, U4, and U6 RNA analogs.

1989 • 122 citations

Probing the structure and function of U2 snRNP with antisense oligonucleotides made of 2′-OMe RNA

1989 • 115 citations

Mutations at the 3′ splice site can be suppressed by compensatory base changes in U1 snRNA in fission yeast

1992 • 109 citations

Compilation of small RNA sequences

1994 • 109 citations

Functional analysis of mutant Xenopus U2 snRNAs

1989 • 103 citations

Group I Intron Self-Splicing with Adenosine: Evidence for a Single Nucleoside-Binding Site

1991 • 100 citations

Mammalian U2 snRNP has a sequence-specific RNA-binding activity.

1989 • 98 citations

Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides

1988 • 93 citations

In vitro reconstitution of functional yeast U2 snRNPs.

1989 • 91 citations

Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicingin vitro

1992 • 77 citations

A 3′ splice site-binding sequence in the catalytic core of a group I intron

1990 • 75 citations

Saccharomyces cerevisiae CYC1 mRNA 5′-End Positioning: Analysis by In Vitro Mutagenesis, Using Synthetic Duplexes with Random Mismatch Base Pairs

1985 • 71 citations

Mutational analysis of conserved nucleotides in a self-splicing group I intron

1990 • 69 citations

Different Small Nuclear Ribonucleoprotein Particles Are Involved in Different Steps of Splicing Complex Formation

1987 • 68 citations

Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.

1991 • 65 citations

U2 snRNA sequences that bind U2-specific proteins are dispensable for the function of U2 snRNP in splicing.

1989 • 64 citations

Mechanism of 3' splice site selection by the catalytic core of the sunY intron of bacteriophage T4: the role of a novel base-pairing interaction in group I introns.

1990 • 63 citations

An axial binding site in the Tetrahymena precursor RNA

1991 • 56 citations

Roles of U4 and U6 snRNAs in the assembly of splicing complexes.

1992 • 52 citations

A new U2 RNA secondary structure provided by phylogenetic analysis of trypanosomatid U2 RNAs.

1990 • 47 citations

Mapping of Branch Sites in trans-Spliced Pre-mRNAs of Trypanosoma brucei

1989 • 46 citations

Saccharomyces cerevisiae CYC1 mRNA 5'-end positioning: analysis by in vitro mutagenesis, using synthetic duplexes with random mismatch base pairs.

1985 • 37 citations

Conserved sequences in the U2 snRNA-encoding genes of Kinetoplastida do not include the putative branchpoint recognition region

1990 • 35 citations

Selection of the 3′‐splice site in group I introns

1989 • 35 citations

Limited functional equivalence of phylogenetic variation in small nuclear RNA: yeast U2 RNA with altered branchpoint complementarity inhibits splicing and produces a dominant lethal phenotype.

1991 • 32 citations

Co-optimization of ribozyme substrate stacking and l-arginine binding

1992 • 27 citations

Mapping of branch sites in trans-spliced pre-mRNAs of Trypanosoma brucei.

1989 • 26 citations

Multiple functional domains of human U2 small nuclear RNA: strengthening conserved stem I can block splicing.

1992 • 22 citations

Compilation of small RNA sequences, 1990

1990 • 16 citations

Selection of small molecules by the Tetrahymena catalytic center

1991 • 15 citations

[35] Compilation of small nuclear RNA sequences

1989 • 14 citations

Compilation of small RNA sequences

1992 • 12 citations

Compilation of small RNA sequences

1991 • 12 citations

The 5′ end domain of U2 snRNA is required to establish the interaction of U2 snRNP with U2 auxiliary factor(s) during mammalian spliceosome assembly

1991 • 10 citations

ATetrahymenaintron nucleotide connected to the GTP/arginine site

1989 • 9 citations