An enhancer screen identifies a gene that encodes the yeast U1 snRNP A protein: implications for snRNP protein function in pre-mRNA splicing.

A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1984 • 2,401 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

The structure of an antigenic determinant in a protein

1984 • 841 citations

Unusual Resistance of Peptidyl Transferase to Protein Extraction Procedures

1992 • 725 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

1990 • 622 citations

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing

1987 • 594 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm

1989 • 417 citations

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

1989 • 391 citations

Structure and Function of Major and Minor Small Nuclear Ribonucleoprotein Particles

1988 • 363 citations

Visualizing the Higher Order Folding of a Catalytic RNA Molecule

1991 • 354 citations

Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae.

1989 • 340 citations

An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.

1991 • 297 citations

Functions of the Abundant U-snRNPs

1988 • 284 citations

Major determinants of the specificity of interaction between small nuclear ribonucleoproteins U1A and U2B" and their cognate RNAs

1990 • 283 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

Pre-mRNA Splicing in Yeast

1989 • 209 citations

RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.

1991 • 196 citations

mRNA splicing efficiency in yeast and the contribution of nonconserved sequences

1985 • 194 citations

Identification and characterization of an RNA molecule that copurifies with RNase P activity from HeLa cells.

1989 • 193 citations

GENETIC ANALYSIS OF THE YEAST CYTOSKELETON

1987 • 179 citations

Classical mutagenesis techniques

2002 • 176 citations

Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.

1991 • 172 citations

Who's on first? The U1 snRNP-5 splice site interaction and splicing

1991 • 156 citations

Identification of two genes coding for the translation elongation factor EF-1 alpha of S. cerevisiae.

1984 • 150 citations

Cloning by function: an alternative approach for identifying yeast homologs of genes from other organisms.

1990 • 149 citations

[18] Classical mutagenesis techniques

1991 • 147 citations

U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts

1991 • 144 citations

Early commitment of yeast pre-mRNA to the spliceosome pathway.

1988 • 143 citations

Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly

1990 • 143 citations

Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA.

1990 • 139 citations

Reconstitution of a group I intron self-splicing reaction with an activator RNA.

1991 • 123 citations

The spliceosome assembly pathway in mammalian extracts.

1992 • 111 citations

The yeast PRP6 gene encodes a U4/U6 small nuclear ribonucleoprotein particle (snRNP) protein, and the PRP9 gene encodes a protein required for U2 snRNP binding.

1990 • 106 citations

The neurospora CYT-18 protein suppresses defects in the phage T4 td intron by stabilizing the catalytically active structure of the intron core

1992 • 106 citations

Antisense probes containing 2-aminoadenosine allow efficient depletion of U5 snRNP from HeLa splicing extracts

1991 • 101 citations

Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing.

1992 • 98 citations

A tyrosyl-tRNA synthetase binds specifically to the group I intron catalytic core.

1992 • 97 citations

The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA.

1991 • 97 citations

An Intron in the Genes for U3 Small Bucleolar RNAs of the Yeast Saccharomyces cerevisiae

1990 • 86 citations

Cloning of a yeast U1 snRNP 70K protein homologue: functional conservation of an RNA-binding domain between humans and yeast.

1991 • 67 citations

Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.

1991 • 65 citations

Activation of the catalytic core of a group I intron by a remote 3' splice junction.

1992 • 62 citations

Multiple domains of U1 snRNA, including U1 specific protein binding sites, are required for splicing.

1990 • 59 citations

Requirements for U2 snRNP addition to yeast pre-mRNA

1992 • 58 citations

Function of P11, a tertiary base pairing in self-splicing introns of subgroup IA

1991 • 56 citations

Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains.

1990 • 55 citations

Genetic depletion indicates a late role for U5 snRNP during in vitro spliceosome assembly

1991 • 54 citations

Mutant Studies on the Prokaryotic Ribosome

1986 • 44 citations

[30] Sequence and structural requirements for efficient translation in yeast

1990 • 42 citations

Universally conserved and yeast-specific U1 snRNA sequences are important but not essential for U1 snRNP function.

1990 • 41 citations

Conserved amino acid residues within and outside of the N-terminal ribonucleoprotein motif of U1A small nuclear ribonucleoprotein involved in U1 RNA binding

1991 • 40 citations

Cloning of the two essential yeast genes, PRP6 and PRP9,and their rapid mapping, disruption and partial sequencing using a linker insertion strategy

1991 • 16 citations