Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

1989 • 2,486 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

The “initiator” as a transcription control element

1989 • 1,597 citations

Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.

1986 • 1,424 citations

Analysis of Sp1 in vivo reveals mutiple transcriptional domains, including a novel glutamine-rich activation motif

1988 • 1,403 citations

λ ZAP: a bacteriophage λ expression vector within vivoexcision properties

1988 • 1,394 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB

1988 • 1,321 citations

EUKARYOTIC TRANSCRIPTIONAL REGULATORY PROTEINS

1989 • 1,299 citations

Splicing of Messenger RNA Precursors

1987 • 919 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

The rapid generation of oligonucleotide-directed mutations at high frequency using phosphorothioate-modified DNA

1985 • 849 citations

A cyclic AMP- and phorbol ester-inducible DNA element

1986 • 780 citations

Cyclic AMP-Responsive DNA-Binding Protein: Structure Based on a Cloned Placental cDNA

1988 • 772 citations

New type of POU domain in germ line-specific protein Oct-4

1990 • 753 citations

A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs

1988 • 747 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

CREM gene: Use of alternative DNA-binding domains generates multiple antagonists of cAMP-induced transcription

1991 • 655 citations

Synergistic activation by the glutamine-rich domains of human transcription factor Sp1

1989 • 539 citations

Developmental switch of CREM function during spermatogenesis: from antagonist to activator

1992 • 495 citations

Tissue-specific enhancer of the human glycoprotein hormone alpha-subunit gene: dependence on cyclic AMP-inducible elements.

1987 • 409 citations

Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acid.

1991 • 395 citations

Differentially expressed isoforms of the mouse retinoic acid receptor beta generated by usage of two promoters and alternative splicing.

1991 • 390 citations

Cyclic AMP regulation of the human glycoprotein hormone alpha-subunit gene is mediated by an 18-base-pair element.

1987 • 293 citations

Functional analysis of alternatively spliced tyrosinase gene transcripts.

1988 • 275 citations

Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains.

1990 • 236 citations

Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic AMP.

1987 • 236 citations

Characterization of motifs which are critical for activity of the cyclic AMP-responsive transcription factor CREB.

1991 • 229 citations

Characterization of a bipartite activator domain in transcription factor CREB

1990 • 228 citations

Multiple sequence elements in the c-fos promoter mediate induction by cAMP.

1989 • 225 citations

Splicing of Messenger RNA Precursors

1987 • 219 citations

Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins.

1988 • 198 citations

Both the basic region and the ‘leucine zipper’ domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.

1990 • 196 citations

Expression of cDNAs for two isoforms of the catalytic subunit of cAMP-dependent protein kinase.

1987 • 194 citations

The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-Dependent protein kinase

1991 • 192 citations

Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing.

1988 • 184 citations

Identification of basal and cyclic AMP regulatory elements in the promoter of the phosphoenolpyruvate carboxykinase gene.

1988 • 169 citations

A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1

1990 • 154 citations

Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes

1990 • 149 citations

Multiple Oct2 isoforms are generated by alternative splicing

1991 • 141 citations

Two distinct forms of active transcription factor CREB (cAMP response element binding protein).

1990 • 132 citations

Characterization of the cAMP responsive elements from the genes for the alpha-subunit of glycoprotein hormones and phosphoenolpyruvate carboxykinase (GTP). Conserved features of nuclear protein binding between tissues and species.

1988 • 121 citations

In vivo monitoring of a cAMP-stimulated DNA-binding activity.

1990 • 93 citations

CellularLocalization and Age-Dependent Changes in mRNA for Cyclic Adenosine 3′,5′-Monophosphate-Dependent Protein Kinases in Rat Testis1

1987 • 75 citations

Tissue-Specific Enhancer of the Human Glycoprotein Hormone α-Subunit Gene: Dependence on Cyclic AMP-Inducible Elements

1987 • 71 citations

Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos.

1989 • 63 citations

Identification of Basal and Cyclic AMP Regulatory Elements in the Promoter of the Phosphoenolpyruvate Carboxykinase Gene

1988 • 61 citations

Characterization of Motifs Which Are Critical for Activity of the Cyclic AMP-Responsive Transcription Factor CREB

1991 • 57 citations

Regulation of gene expression by transfected subunits of cAMP‐dependent protein kinase

1990 • 18 citations