PDGF and cardiovascular disease

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Mechanism of Action and In Vivo Role of Platelet-Derived Growth Factor

1999 • 2,386 citations

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

1998 • 1,943 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

Physiological aspects of primary hypertension.

1982 • 1,787 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium.

1983 • 1,441 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF

1991 • 1,081 citations

Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis

2002 • 1,027 citations

Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.

1988 • 1,024 citations

Endothelial-pericyte interactions in angiogenesis

2003 • 1,022 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 975 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1996 • 867 citations

LRP: a multifunctional scavenger and signaling receptor

2001 • 856 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Mouse Models of Atherosclerosis

1996 • 701 citations

Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

1992 • 681 citations

MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B

1999 • 665 citations

Regulation of wound-healing angiogenesis-effect of oxygen gradients and inspired oxygen concentration.

1981 • 644 citations

Two Different Subunits Associate to Create Isoform-Specific Platelet-derived Growth Factor Receptors

1989 • 633 citations

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

2003 • 621 citations

PDGF-C is a new protease-activated ligand for the PDGF α-receptor

2000 • 612 citations

Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis

1990 • 584 citations

Significance of quiescent smooth muscle migration in the injured rat carotid artery.

1985 • 570 citations

LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis

2003 • 557 citations

Chemotaxis of monocytes and neutrophils to platelet-derived growth factor.

1982 • 553 citations

The NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formation

2000 • 545 citations

PDGF-D is a specific, protease-activated ligand for the PDGF β-receptor

2001 • 542 citations

Remodeling With Neointima Formation in the Mouse Carotid Artery After Cessation of Blood Flow

1997 • 514 citations

Evidence for apoptosis in human atherogenesis and in a rat vascular injury model.

1995 • 484 citations

Platelet-derived growth factor mRNA detection in human atherosclerotic plaques by in situ hybridization.

1988 • 481 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 481 citations

Platelet-derived growth factor. I. High yield purification and evidence for multiple forms.

1982 • 457 citations

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

2003 • 436 citations

PDGF ligand and receptor gene expression during repair of arterial injury.

1990 • 431 citations

Vasoconstriction: A New Activity for Platelet-Derived Growth Factor

1986 • 430 citations

PDGF-D, a new protease-activated growth factor

2001 • 389 citations

Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy

2002 • 378 citations

Developmental roles of platelet‐derived growth factors

2001 • 365 citations

Chronic Rejection

2001 • 361 citations

Cardiac transplant atherosclerosis.

1987 • 359 citations

Mechanisms of arterial graft healing. Rapid transmural capillary ingrowth provides a source of intimal endothelium and smooth muscle in porous PTFE prostheses.

1986 • 352 citations

Significance of quiescent smooth muscle migration in the injured rat carotid artery.

1985 • 342 citations

Young Adult Bone Marrow–Derived Endothelial Precursor Cells Restore Aging-Impaired Cardiac Angiogenic Function

2002 • 316 citations

Alterations in vascular smooth muscle mass in the spontaneously hypertensive rat. Role of cellular hypertrophy, hyperploidy, and hyperplasia.

1982 • 315 citations

Hemodynamics and atherosclerosis1

1982 • 305 citations

Remodeling of Developing and Mature Arteries

1993 • 285 citations

PARAQUAT POISONING

1976 • 280 citations

Platelet-derived Growth Factor C (PDGF-C), a Novel Growth Factor That Binds to PDGF α and β Receptor

2001 • 278 citations

RETRACTED: Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class.

1995 • 270 citations

Vascular Bed–specific Expression of an Endothelial Cell Gene Is Programmed by the Tissue Microenvironment

1997 • 269 citations

Platelet-derived Growth Factor (PDGF)-induced Tyrosine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein (LRP)

2002 • 250 citations

Recombinant platelet-derived growth factor B gene expression in porcine arteries induce intimal hyperplasia in vivo.

1993 • 247 citations

INDUCTION OF B-TYPE RECEPTORS FOR PLATELET-DERIVED GROWTH FACTOR IN VASCULAR INFLAMMATION: POSSIBLE IMPLICATIONS FOR DEVELOPMENT OF VASCULAR PROLIFERATIVE LESIONS

1988 • 247 citations

Platelet-derived growth factor gene expression in human atherosclerotic plaques and normal artery wall.

1988 • 245 citations

New Anti–Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E–Knockout Mice

2001 • 244 citations

Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury.

1993 • 243 citations

Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets

1990 • 226 citations

Angiogenesis stimulated by PDGF‐CC, a novel member in the PDGF family, involves activation of PDGFR‐aa and ‐ap receptors

2002 • 223 citations

New Members of the Platelet-Derived Growth Factor Family of Mitogens

2002 • 221 citations

Expression of the sis gene by endothelial cells in culture and in vivo.

1984 • 221 citations

Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein

1976 • 221 citations

Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta.

1998 • 218 citations

Activation of PDGF receptor α in vascular smooth muscle cells by mechanical stress

1998 • 216 citations

Platelet-derived Growth Factor Mediates Tyrosine Phosphorylation of the Cytoplasmic Domain of the Low Density Lipoprotein Receptor-related Protein in Caveolae

2002 • 216 citations

Platelet-derived growth factor. Isolation by a large-scale procedure and analysis of subunit composition

1981 • 215 citations

Expression and developmental control of platelet-derived growth factor A-chain and B-chain/Sis genes in rat aortic smooth muscle cells.

1988 • 214 citations

Human platelet-derived growth factor (PDGF): purification of PDGF-I and PDGF-II and separation of their reduced subunits.

1981 • 211 citations

Platelet-derived growth factor in vivo: levels, activity, and rate of clearance

1984 • 203 citations

Platelet-derived growth factor A chain: gene structure, chromosomal location, and basis for alternative mRNA splicing.

1988 • 187 citations

Platelet-derived growth factor in vivo: levels, activity, and rate of clearance

1984 • 185 citations

Novel PDGF family members: PDGF-C and PDGF-D

2003 • 184 citations

Worldwide thoracic organ transplantation: a report from the UNOS/ISHLT International Registry for Thoracic Organ Transplantation.

1996 • 183 citations

Compartmentalization of PDGF on extracellular binding sites dependent on exon-6-encoded sequences.

1992 • 179 citations

sis (platelet-derived growth factor B chain) gene transcript levels are elevated in human atherosclerotic lesions compared to normal artery.

1987 • 172 citations

Studies on the pathogenesis of atheroarteriosclerosis induced in rabbit cardiac allografts by the synergy of graft rejection and hypercholesterolemia.

1977 • 171 citations

Intimal lesion formation in rat carotid arteries after endothelial denudation in absence of medial injury.

1990 • 170 citations

Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice

2001 • 166 citations

Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension.

1995 • 160 citations

Many Roads Lead to a Broken Heart: The Genetics of Dilated Cardiomyopathy

2001 • 159 citations

PDGF-D is a potent transforming and angiogenic growth factor

2003 • 155 citations

Transgenic Overexpression of Platelet-Derived Growth Factor-C in the Mouse Heart Induces Cardiac Fibrosis, Hypertrophy, and Dilated Cardiomyopathy

2003 • 152 citations

Antisense Oligonucleotide Inhibition of PDGFR-β Receptor Subunit Expression Directs Suppression of Intimal Thickening

1997 • 152 citations

PDGF α-receptor is unresponsive to PDGF-AA in aortic smooth muscle cells from the NG2 knockout mouse

1999 • 150 citations

Platelet-Derived Growth Factor-AB Limits the Extent of Myocardial Infarction in a Rat Model

2002 • 149 citations

The Two PDGF Receptors Maintain Conserved Signaling In Vivo despite Divergent Embryological Functions

2001 • 147 citations

Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions.

1994 • 140 citations

Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.

1988 • 139 citations

Intimal lesion formation in rat carotid arteries after endothelial denudation in absence of medial injury.

1990 • 133 citations

Shear stress regulates smooth muscle proliferation and neointimal thickening in porous polytetrafluoroethylene grafts.

1991 • 133 citations

Chromosomal Location, Exon Structure, and Vascular Expression Patterns of the Human PDGFC and PDGFD Genes

2001 • 132 citations

Platelet-Derived Growth Factor Ligand and Receptor Expression in Response to Altered Blood Flow In Vivo

1997 • 127 citations

Inhibition of platelet‐derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation

1997 • 125 citations

PDGF mediates cardiac microvascular communication.

1998 • 123 citations

Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages

1998 • 117 citations

Platelet-derived growth factor promotes human peripheral monocyte activation

1985 • 116 citations

Acute Reductions in Blood Flow and Shear Stress Induce Platelet-Derived Growth Factor-A Expression in Baboon Prosthetic Grafts

1996 • 112 citations

Participation of the NG2 Proteoglycan in Rat Aortic Smooth Muscle Cell Responses to Platelet-Derived Growth Factor

1995 • 110 citations

PDGFβ Receptor Blockade Inhibits Intimal Hyperplasia in the Baboon

1999 • 101 citations

Negative feedback regulation of human platelets via autocrine activation of the platelet-derived growth factor alpha-receptor.

1994 • 98 citations

PLATELET-DERIVED GROWTH FACTOR-BB AND MONOCYTE CHEMOTACTIC PROTEIN-1 INDUCE HUMAN PERIPHERAL BLOOD MONOCYTES TO EXPRESS TISSUE FACTOR

1996 • 98 citations

Morphology of solid organ allograft arteriopathy: identification of proliferating intimal cell populations.

1989 • 95 citations

Platelet-derived growth factor is a potent biologic response modifier of T cells.

1991 • 89 citations

Lipoprotein lipase and atherosclerosis

2003 • 89 citations

Restenosis Following Angioplasty in the Swine Coronary Artery Is Inhibited By an Orally Active PDGF-Receptor Tyrosine Kinase Inhibitor, RPR101511A

1999 • 87 citations

Polarized secretion of a platelet-derived growth factor-like chemotactic factor by endothelial cells in vitro.

1987 • 86 citations

Blockade of Platelet-Derived Growth Factor or Its Receptors Transiently Delays but Does Not Prevent Fibrous Cap Formation in ApoE Null Mice

2002 • 86 citations

Alpha 1-adrenergic stimulation of platelet-derived growth factor A-chain gene expression in rat aorta.

1990 • 85 citations

Intimal Hyperplasia Recurs After Removal of PDGF-AB and -BB Inhibition in the Rat Carotid Artery Injury Model

2000 • 83 citations

The Role of Alpha and Beta Platelet-Derived Growth Factor Receptor in the Vascular Response to Injury in Nonhuman Primates

1999 • 80 citations

PDGF-C Expression in the Developing and Normal Adult Human Kidney and in Glomerular Diseases

2003 • 79 citations

Expression of platelet derived growth factor B chain and beta receptor in human coronary arteries after percutaneous transluminal coronary angioplasty: an immunohistochemical study.

1996 • 79 citations

Prevention of Cardiac Allograft Arteriosclerosis by Protein Tyrosine Kinase Inhibitor Selective for Platelet-Derived Growth Factor Receptor

1999 • 74 citations

Obstructive Uropathy in Mice and Humans

2003 • 69 citations

Differential Expression of α ₁ Type VIII Collagen in Injured Platelet-Derived Growth Factor-BB–Stimulated Rat Carotid Arteries

1996 • 69 citations

Low Density Lipoprotein Receptor-related Protein Mediates Apolipoprotein E Inhibition of Smooth Muscle Cell Migration

2002 • 67 citations

Platelet-derived growth factor ligand and receptor expression by large vessel endothelium in vivo.

1995 • 67 citations

Expression of platelet-derived growth factor beta receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor BB dimer on the cellular function.

1993 • 65 citations

Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo. An autocrine mechanism promoting hypertensive vascular hypertrophy.

1995 • 62 citations

PDGF AA homodimers are potent chemoattractants for fibroblasts and neutrophils, and for monocytes activated by lymphocytes or cytokines

1992 • 61 citations

In situ detection of platelet-derived growth factor-A and -B chain mRNA in human coronary arteries after percutaneous transluminal coronary angioplasty.

1996 • 61 citations

The platelet‐derived growth factor isomers, PDGF‐AA, PDGF‐AB and PDGF‐BB, induce contraction of vascular smooth muscle cells by different intracellular mechanisms

1990 • 61 citations

Regional expression of the platelet-derived growth factor and its receptors in a primate graft model of vessel wall assembly.

1993 • 59 citations

Alternative splicing of the platelet-derived growth factor A-chain transcript occurs in normal as well as tumor cells and is conserved among mammalian species.

1989 • 58 citations

Weekly Dosing With the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor SU9518 Significantly Inhibits Arterial Stenosis

2001 • 54 citations

Expression of LDL receptor-related protein/alpha 2-macroglobulin receptor in human normal and atherosclerotic arteries.

1994 • 53 citations

Platelet-derived growth factor-D expression in developing and mature human kidneys

2002 • 52 citations

Inhibition of Human Natural Killer Cell Activity by Platelet‐Derived Growth Factor (PDGF)

1991 • 50 citations

Expression of PDGF alpha-receptor in renal arteriosclerosis and rejecting renal transplants.

1998 • 50 citations

Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells.

1995 • 50 citations

Platelet-derived growth factor receptors on macrovascular endothelial cells mediate relaxation via nitric oxide in rat aorta.

1992 • 50 citations

Platelet-derived growth factor BB induces functional vascular anastomoses in vivo.

1995 • 49 citations

Immunohistochemical analysis of platelet-derived growth factor and basic fibroblast growth factor in cardiac biopsy and autopsy specimens of heart transplant patients

1996 • 46 citations

In Vivo Activation of Rat Aortic Platelet-Derived Growth Factor and Epidermal Growth Factor Receptors by Angiotensin II and Hypertension

2000 • 46 citations

PDGF C Is A Selective α Platelet-Derived Growth Factor Receptor Agonist That Is Highly Expressed in Platelet α Granules and Vascular Smooth Muscle

2004 • 46 citations

Natural Regulators of T-Cell Lymphokine Production In Vivo

1992 • 45 citations

Chimera Analysis Reveals That Fibroblasts and Endothelial Cells Require Platelet-Derived Growth Factor Receptorβ Expression for Participation in Reactive Connective Tissue Formation in Adults but Not during Development

1999 • 44 citations

Modulation of smooth muscle proliferation in rat carotid artery by platelet-derived mediators and fibroblast growth factor-2

2001 • 42 citations

Endogenously elicited antibodies to platelet derived growth factor‐BB and platelet cytosolic protein inhibit aortic lesion development in the cholesterol‐fed rabbit

1997 • 39 citations

Efficacy of the novel selective platelet-derived growth factor receptor antagonist CT52923 on cellular proliferation, migration, and suppression of neointima following vascular injury.

2001 • 38 citations

Chimera Analysis Supports a Predominant Role of PDGFRβ in Promoting Smooth-Muscle Cell Chemotaxis after Arterial Injury

2003 • 36 citations

A High Level of CCAAT-Enhancer Binding Protein-δ Expression Is a Major Determinant for Markedly Elevated Differential Gene Expression of the Platelet-Derived Growth Factor-α Receptor in Vascular Smooth Muscle Cells of Genetically Hypertensive Rats

1999 • 35 citations

Collagen-induced binding to human platelets of platelet-derived growth factor leading to inhibition of P43 and P20 phosphorylation

1989 • 35 citations

Bolus Endovascular PDGFR-β Antisense Treatment Suppressed Intimal Hyperplasia in a Rat Carotid Injury Model

2000 • 34 citations

PDGF Receptor Protein Tyrosine Kinase Expression in the Balloon-Injured Rat Carotid Artery

1997 • 33 citations

Importance of PDGF receptor expression in accelerated atherosclerosis-chronic rejection.

1989 • 32 citations

Increase in tone and intracellular Ca²⁺ in rabbit isolated ear artery by platelet‐derived growth factor

1995 • 31 citations

Role of Long-Form PDGF A-Chain in the Growth of Vascular Smooth Muscle Cells From Spontaneously Hypertensive Rats

1997 • 30 citations

Antisense oligodeoxynucleotide complementary to platelet-derived growth factor A-chain messenger RNA inhibits the arterial proliferation in spontaneously hypertensive rats without altering their blood pressures

1997 • 30 citations

Expression of platelet-derived growth factor receptor in rat heart allografts.

1991 • 28 citations

Role of Platelet-Derived Growth Factor in Allograft Vasculopathy

2000 • 28 citations

Platelet-derived growth factor receptor inhibition reduces allograft arteriosclerosis of heart and aorta in cholesterol-fed rabbits

2003 • 27 citations

Age- and microenvironment-associated influences by platelet-derived growth factor on T cell function.

1994 • 23 citations

Effects of Platelet-Derived Growth Factor on the Synthesis of Lipoprotein Lipase in Human Monocyte–Derived Macrophages

1995 • 23 citations

Platelet-Derived Growth Factor B-Chain of Hematopoietic Origin Is Not Necessary for Granulation Tissue Formation and Its Absence Enhances Vascularization

2001 • 23 citations

CONFIRMATION OF ALTERNATIVELY SPLICED PLATELET-DERIVED GROWTH FACTOR-A CHAIN AND CORRELATION WITH EXPRESSION OF PDGF RECEPTOR-α IN HUMAN CARDIAC ALLOGRAFTS1,2

1995 • 23 citations

Allograft vascular disease: a disease not limited to hearts.

1992 • 21 citations

Endogenous Neutralizing Antibodies Against Platelet-Derived Growth Factor-AA Inhibit Atherogenesis in the Cholesterol-Fed Rabbit

2001 • 20 citations

Tyrosine phosphorylation of platelet derived growth factor beta receptors in coronary artery lesions: implications for vascular remodelling after directional coronary atherectomy and unstable angina pectoris

1998 • 19 citations

Increased Expression of Genes for Platelet-Derived Growth Factor in Circulating Mononuclear Cells of Hypercholesterolemic Patients

1996 • 18 citations

Role of platelet factors in the growth of cells in culture.

1978 • 17 citations

Expression of platelet-derived growth factor receptor in rat heart allografts.

1991 • 16 citations

Platelet‐derived growth factor causes endothelium‐independent relaxation of rabbit mesenteric artery via the release of a prostanoid

2000 • 14 citations

Tissue distribution of macrophages, class II transplantation antigens, and receptors for platelet-derived growth factor in normal and rejected human kidneys.

1987 • 13 citations

Expression of platelet-derived growth factor in the development of cardiac allograft vasculopathy in the rat

1997 • 12 citations

PDGF-BB decreases systolic blood pressure through an increase in macrovascular compliance in rats

1997 • 12 citations

Association between the degree of platelet-derived growth factor-A chain mRNA expression and coronary arteriosclerosis in the transplanted heart

1998 • 10 citations

PDGF receptor inhibition prevents cardiac allograft arteriosclerosis in cholesterol-fed rabbits

2001 • 6 citations