Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

In Vitro Cultivation of Human Tumors: Establishment of Cell Lines Derived From a Series of Solid Tumors2

1973 • 2,213 citations

Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus

1983 • 1,657 citations

Simian Sarcoma Virus onc Gene, v- sis , Is Derived from the Gene (or Genes) Encoding a Platelet-Derived Growth Factor

1983 • 1,550 citations

cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines

1986 • 786 citations

A significant part of macrophage-derived growth factor consists of at least two forms of PDGF

1985 • 719 citations

Speculations on RNA splicing

1981 • 639 citations

Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells

1982 • 507 citations

A human osteosarcoma cell line secretes a growth factor structurally related to a homodimer of PDGF A-chains

1986 • 418 citations

Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity

1986 • 380 citations

The c-sis gene encodes a precursor of the B chain of platelet-derived growth factor.

1984 • 376 citations

Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor

1983 • 352 citations

Two established in vitro cell lines from human mesenchymal tumours

1967 • 331 citations

Coexpression of the sis and myc proto-oncogenes in developing human placenta suggests autocrine control of trophoblast growth

1985 • 328 citations

Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis

1985 • 286 citations

Platelet-derived growth factor: Identification of constituent polypeptide chains

1982 • 275 citations

Chromosomal Localization of the Human Homolog (c- sis ) of the Simian Sarcoma Virus onc Gene

1982 • 262 citations

Purification and properties of porcine platelet-derived growth factor.

1984 • 260 citations

Expression of a Platelet-Derived Growth Factor-Like Protein in Simian Sarcoma Virus Transformed Cells

1983 • 246 citations

Possible positive autocrine feedback in the prereplicative phase of human fibroblasts

1987 • 234 citations

Expression of the sis gene by endothelial cells in culture and in vivo.

1984 • 221 citations

Antibodies against platelet-derived growth factor inhibit acute transformation by simian sarcoma virus

1985 • 205 citations

Human-Proto-Oncogene Nucleotide Sequences Corresponding to the Transforming Region of Simian Sarcoma Virus

1984 • 203 citations

Chemical and biological properties of a growth factor from human‐cultured osteosarcoma cells: Resemblance with platelet‐derived growth factor

1980 • 188 citations

Human melanoma cell lines of primary and metastatic origin express the genes encoding the chains of platelet-derived growth factor (PDGF) and produce a PDGF-like growth factor.

1986 • 187 citations

Chromosomal mapping of the simian sarcoma virus onc gene analogue in human cells.

1982 • 181 citations

A New Method for Purifying Lambda DNA From Phage Lysates

1985 • 178 citations

Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor

1984 • 170 citations

Blockade of autocrine stimulation in simian sarcoma virus-transformed cells reverses down-regulation of platelet-derived growth factor receptors.

1984 • 163 citations

Rat skeletal myoblasts and arterial smooth muscle cells express the gene for the A chain but not the gene for the B chain (c-sis) of platelet-derived growth factor (PDGF) and produce a PDGF-like protein.

1986 • 162 citations

The v-sis/PDGF-2 transforming gene product localizes to cell membranes but is not a secretory protein.

1985 • 143 citations

Primary melanoma cells of the vertical growth phase: similarities to metastatic cells.

1985 • 141 citations

Evidence That the v- sis Gene Product Transforms by Interaction with the Receptor for Platelet-Derived Growth Factor

1985 • 138 citations

Detection of c- sis Transcripts and Synthesis of PDGF-Like Proteins by Human Osteosarcoma Cells

1984 • 134 citations

Alternative RNA splicing affects function of encoded platelet-derived growth factor A chain

1987 • 130 citations

Synthesis and secretion of proteins resembling platelet-derived growth factor by human glioblastoma and fibrosarcoma cells in culture.

1985 • 125 citations

Modulation of the sis Gene Transcript During Endothelial Cell Differentiation in Vitro

1985 • 117 citations

Cultured human endothelial cells express platelet-derived growth factor A chain.

1987 • 115 citations

Localization of the human c-sis oncogene in Ph1-positive and Ph1- negative chronic myelocytic leukemia by in situ hybridization

1984 • 101 citations

cDNA clones reveal differences between human glial and endothelial cell platelet-derived growth factor A-chains

1987 • 99 citations

Clonal variation in the production of a platelet-derived growth factor-like protein and expression of corresponding receptors in a human malignant glioma.

1986 • 89 citations

Induction of platelet-derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines.

1987 • 77 citations

Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product.

1985 • 72 citations

Expression of multiple growth factors in a human lung cancer cell line

1987 • 63 citations

In vitro mutagenesis of the v-sis transforming gene defines functional domains of its growth factor-related product.

1985 • 54 citations

The phenotypic characteristics of simian sarcoma virus-transformed human fibroblasts suggest that the v-sis gene product acts solely as a PDGF receptor agonist in cell transformation.

1986 • 53 citations

Chick proα2 (I) collagen gene; exon location and coding potential for the prepropeptide

1983 • 53 citations

Neuroblastoma cells express c-sis and produce a transforming growth factor antigenically related to the platelet-derived growth factor.

1985 • 48 citations

Deletions in the N-terminal coding region of the v-sis gene: determination of the minimal transforming region

1986 • 33 citations

Human neoplastic cells in tissue culture: two established cell lines derived from giant cell tumor and fibrosarcoma.

1976 • 20 citations

Expression of multiple growth factors in a human lung cancer cell line

1987 • 2 citations