Low Density Lipoprotein Receptor-related Protein Mediates Apolipoprotein E Inhibition of Smooth Muscle Cell Migration

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

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NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

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Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

1989 • 600 citations

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1983 • 548 citations

Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.

1996 • 486 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Interactions of the Low Density Lipoprotein Receptor Gene Family with Cytosolic Adaptor and Scaffold Proteins Suggest Diverse Biological Functions in Cellular Communication and Signal Transduction

2000 • 458 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist

1994 • 311 citations

Apolipoprotein E and atherosclerosis

2000 • 247 citations

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1992 • 244 citations

The LDL Receptor Gene Family

2001 • 230 citations

Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein

1996 • 226 citations

The YXXL Motif, but Not the Two NPXY Motifs, Serves as the Dominant Endocytosis Signal for Low Density Lipoprotein Receptor-related Protein

2000 • 223 citations

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1991 • 210 citations

Apolipoprotein E Inhibits Platelet Aggregation through the L-Arginine:Nitric Oxide Pathway

1997 • 201 citations

Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands.

1998 • 183 citations

Extracellular signal-regulated kinase functions in the urokinase receptor-dependent pathway by which neutralization of low density lipoprotein receptor-related protein promotes fibrosarcoma cell migration and Matrigel invasion

2000 • 164 citations

Apolipoprotein E is a biologically active constituent of the normal immunoregulatory lipoprotein, LDL-In.

1986 • 148 citations

Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase

1998 • 143 citations

Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.

1980 • 126 citations

A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins

1998 • 124 citations

Tyrosine-phosphorylated Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Associates with the Adaptor Protein SHC in SRC-transformed Cells

2001 • 124 citations

Lipoprotein binding and endosomal itinerary of the low density lipoprotein receptor-related protein in rat liver.

1989 • 112 citations

Identification and characterization of LRP8 (apoER2) in human blood platelets

1999 • 107 citations

Contrasting Effects of Plasminogen Activators, Urokinase Receptor, and LDL Receptor–Related Protein on Smooth Muscle Cell Migration and Invasion

1996 • 100 citations

Receptor-mediated endocytosis of tissue-type plasminogen activator by low density lipoprotein receptor-related protein on human hepatoma HepG2 cells

1993 • 99 citations

Embryonic Fibroblasts That Are Genetically Deficient in Low Density Lipoprotein Receptor-related Protein Demonstrate Increased Activity of the Urokinase Receptor System and Accelerated Migration on Vitronectin

1997 • 93 citations

Apolipoprotein E Inhibition of Vascular Smooth Muscle Cell Proliferation but Not the Inhibition of Migration Is Mediated Through Activation of Inducible Nitric Oxide Synthase

2000 • 84 citations

A comparison of the roles of the low density lipoprotein (LDL) receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo

1993 • 78 citations

Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19.

1994 • 74 citations

Platelet-derived growth factor-BB (PDGF-BB) regulation of migration and focal adhesion kinase phosphorylation in rabbit aortic vascular smooth muscle cells: roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinases

1999 • 73 citations

Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells

1993 • 71 citations

Identification of a lymphocyte surface receptor for low density lipoprotein inhibitor, an immunoregulatory species of normal human serum low density lipoprotein.

1978 • 67 citations

Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism

1997 • 66 citations

Apolipoprotein E Receptor Binding VersusHeparan Sulfate Proteoglycan Binding in Its Regulation of Smooth Muscle Cell Migration and Proliferation

2001 • 59 citations

Perlecan Mediates the Antiproliferative Effect of Apolipoprotein E on Smooth Muscle Cells

1999 • 51 citations

LDL receptor–related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice

2001 • 48 citations

The Mouse Low-Density Lipoprotein Receptor Gene: cDNA Sequence and Exon-Intron Structure

1993 • 36 citations

Inhibition of Ca2+ accumulation in mitogen-activated lymphocytes: role of membrane-bound plasma lipoproteins.

1980 • 35 citations

Expression of lipoprotein receptors and related molecules in atherosclerotic lesions

1996 • 35 citations

Inhibition by membrane-bound low-density lipoproteins of the primary inductive events of mitogen-stimulated lymphocyte activation.

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Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA

1993 • 31 citations

Close encounters with apolipoprotein E receptors

1996 • 31 citations

Apolipoprotein E: a cholesterol transport protein with lipid transport-independent cell signaling properties

2001 • 28 citations

Cloning of a complementary deoxyribonucleic acid encoding the murine homolog of the very low density lipoprotein/apolipoprotein-E receptor: expression pattern and assignment of the gene to mouse chromosome 19 [published erratum appears in Endocrinology 1995 Feb;136(2):795]

1994 • 27 citations

Activation by .ALPHA.1-Adrenergic Agonists of the Progression Phase in the Proliferation of Primary Cultures of Smooth Muscle Cells in Mouse and Rat Aorta.

1995 • 20 citations

Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss

1998 • 16 citations

Inhibition of ADP-induced platelet aggregation by apoE is not mediated by membrane cholesterol depletion

1996 • 8 citations