Functional Blockade of Platelet-Derived Growth Factor Receptor-β but Not of Receptor-α Prevents Vascular Smooth Muscle Cell Accumulation in Fibrous Cap Lesions in Apolipoprotein E–Deficient Mice

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

The pathogenesis of atherosclerosis: a perspective for the 1990s

1993 • 10,730 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors

1986 • 1,244 citations

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

1994 • 1,123 citations

Inhibition of Neointimal Smooth Muscle Accumulation After Angioplasty by an Antibody to PDGF

1991 • 1,081 citations

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

1994 • 984 citations

Quantitative assessment of atherosclerotic lesions in mice

1987 • 957 citations

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

1996 • 867 citations

The PDGFα receptor is required for neural crest cell development and for normal patterning of the somites

1997 • 706 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Expression and function of the interleukin 7 receptor in murine lymphocytes.

1993 • 496 citations

Platelet-derived growth factor: purification and partial characterization.

1979 • 436 citations

Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice.

1998 • 304 citations

Prominent Role of P-Selectin in the Development of Advanced Atherosclerosis in ApoE-Deficient Mice

2000 • 262 citations

Antisense Oligonucleotide Inhibition of PDGFR-β Receptor Subunit Expression Directs Suppression of Intimal Thickening

1997 • 152 citations

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor.

1992 • 143 citations

Receptor tyrosine kinase stimulates cell-matrix adhesion by phosphatidylinositol 3 kinase and phospholipase C-gamma 1 pathways

1995 • 108 citations

PDGFβ Receptor Blockade Inhibits Intimal Hyperplasia in the Baboon

1999 • 101 citations

Intraperitoneal Administration of Anti–c-fmsMonoclonal Antibody Prevents Initial Events of Atherogenesis but Does Not Reduce the Size of Advanced Lesions in Apolipoprotein E–Deficient Mice

1999 • 92 citations

The Role of Alpha and Beta Platelet-Derived Growth Factor Receptor in the Vascular Response to Injury in Nonhuman Primates

1999 • 80 citations

Expression of platelet derived growth factor B chain and beta receptor in human coronary arteries after percutaneous transluminal coronary angioplasty: an immunohistochemical study.

1996 • 79 citations

Expression and Characterization of Human CD4: Immunoglobulin Fusion Proteins

1990 • 73 citations

In situ detection of platelet-derived growth factor-A and -B chain mRNA in human coronary arteries after percutaneous transluminal coronary angioplasty.

1996 • 61 citations

Platelet-derived growth factor (PDGF) activates primitive hematopoietic precursors (pre-CFCmulti) by up-regulating IL-1 in PDGF receptor-expressing macrophages.

1993 • 36 citations

Platelet-Derived Growth Factor Three isoforms that bind to two distinct cell surface receptors

1989 • 29 citations

A Novel Aortic Smooth Muscle Cell Line Obtained from p53 Knock Out Mice Expresses Several Differentiation Characteristics

1997 • 26 citations