Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1‐phosphate

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Vascular Endothelial Cell Adherens Junction Assembly and Morphogenesis Induced by Sphingosine-1-Phosphate

1999 • 999 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation.

1991 • 627 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors.

1990 • 474 citations

Dual Actions of Sphingosine-1-Phosphate: Extracellular through the Gi-coupled Receptor Edg-1 and Intracellular to Regulate Proliferation and Survival

1998 • 468 citations

Sphingosine-1-phosphate: a platelet-activating sphingolipid released from agonist-stimulated human platelets

1995 • 435 citations

Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor.

1996 • 280 citations

EDG1 Is a Functional Sphingosine-1-phosphate Receptor That Is Linked via a Gi/o to Multiple Signaling Pathways, Including Phospholipase C Activation, Ca2+Mobilization, Ras-Mitogen-activated Protein Kinase Activation, and Adenylate Cyclase Inhibition

1998 • 279 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids¹

1997 • 247 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

1992 • 223 citations

Sphingosine 1-Phosphate Induces Platelet Activation through an Extracellular Action and Shares a Platelet Surface Receptor with Lysophosphatidic Acid

1997 • 200 citations

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways

1998 • 195 citations

Sphingosine 1-Phosphate-induced Cell Rounding and Neurite Retraction Are Mediated by the G Protein-coupled Receptor H218

1999 • 183 citations

EDG3 Is a Functional Receptor Specific for Sphingosine 1-Phosphate and Sphingosylphosphorylcholine with Signaling Characteristics Distinct from EDG1 and AGR16

1999 • 176 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

Discussion

1999 • 154 citations

Molecular Cloning of a Novel Putative G Protein-Coupled Receptor Expressed in the Cardiovascular System

1993 • 150 citations

Naturally Occurring Analogs of Lysophosphatidic Acid Elicit Different Cellular Responses through Selective Activation of Multiple Receptor Subtypes

1998 • 124 citations

Edg-2/Vzg-1 Couples to the Yeast Pheromone Response Pathway Selectively in Response to Lysophosphatidic Acid

1998 • 118 citations

Lysophosphatidic Acid Stimulates the G-protein-coupled Receptor EDG-1 as a Low Affinity Agonist

1998 • 116 citations

Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines

1991 • 109 citations

Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: A new group of phospholipid mediators?

1982 • 89 citations

Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?

1982 • 84 citations

Lysophosphatidic acid-induced aggregation of human and feline platelets: Structure-activity relationship

1981 • 83 citations

Sphingosine 1-Phosphate Regulates Melanoma Cell Motility through a Receptor-Coupled Extracellular Action and in a Pertussis Toxin-Insensitive Manner

1997 • 78 citations

Structure−Activity Analysis of the Effects of Lysophosphatidic Acid on Platelet Aggregation

1999 • 76 citations

Sphingosine 1-Phosphate Stimulates Fibronectin Matrix Assembly Through a Rho-Dependent Signal Pathway

1999 • 73 citations

Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation

1992 • 51 citations

Sphingosine‐1‐Phosphate as an Intercellular Signaling Molecule^a

1998 • 19 citations

Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85α subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated human platelets

1994 • 15 citations