Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Control of adhesion-dependent cell survival by focal adhesion kinase.

1996 • 1,113 citations

Sphingosine-1-Phosphate as a Ligand for the G Protein-Coupled Receptor EDG-1

1998 • 1,003 citations

Inhibition by cAMP of Ras-Dependent Activation of Raf

1993 • 955 citations

The CA 125 tumour-associated antigen: a review of the literature

1989 • 931 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes

1988 • 669 citations

The bioactive phospholipid lysophosphatidic acid is released from activated platelets

1993 • 653 citations

Lysophosphatidic Acid as a Potential Biomarker for Ovarian and Other Gynecologic Cancers

1998 • 642 citations

Adjuvant Therapy in Stage I and Stage II Epithelial Ovarian Cancer

1990 • 571 citations

Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid

1999 • 536 citations

Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid

1998 • 535 citations

Secretory phospholipase A2 generates the novel lipid mediator lysophosphatidic acid in membrane microvesicles shed from activated cells

1995 • 523 citations

Molecular Cloning and Characterization of a Novel Human G-protein-coupled Receptor, EDG7, for Lysophosphatidic Acid

1999 • 517 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

CA 125: The past and the Future

1998 • 396 citations

PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway

1999 • 367 citations

Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients.

1995 • 325 citations

Acyltransferases and Transacylases Involved in Fatty Acid Remodeling of Phospholipids and Metabolism of Bioactive Lipids in Mammalian Cells

1997 • 293 citations

Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1

2000 • 291 citations

Lysophospholipids activate ovarian and breast cancer cells

1995 • 289 citations

A single receptor encoded by vzg-1 / lp _A1 / edg- 2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid

1998 • 280 citations

Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

1994 • 264 citations

The Cell of Origin of Ovarian Epithelial Tumors and the Ovarian Surface Epithelium Dogma: Does the Emperor Have No Clothes?

1999 • 261 citations

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1999 • 258 citations

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1

1998 • 252 citations

Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites

1999 • 247 citations

Lysophospholipid Growth Factors in the Initiation, Progression, Metastases, and Management of Ovarian Cancer

2000 • 243 citations

The biology of ovarian cancer.

1998 • 233 citations

Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

1993 • 233 citations

EDG6, a Novel G-Protein-Coupled Receptor Related to Receptors for Bioactive Lysophospholipids, Is Specifically Expressed in Lymphoid Tissue

1998 • 231 citations

Toward an optimal algorithm for ovarian cancer screening with longitudinal tumor markers

1995 • 231 citations

Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling

1998 • 223 citations

Hormonal aspects of epithelial ovarian cancer: review of epidemiological evidence

1998 • 202 citations

Sphingosine 1-Phosphate-induced Cell Proliferation, Survival, and Related Signaling Events Mediated by G Protein-coupled Receptors Edg3 and Edg5

2000 • 196 citations

Induction of in Vitro Tumor Cell Invasion of Cellular Monolayers by Lysophosphatidic Acid or Phospholipase D

1993 • 185 citations

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin

1989 • 185 citations

Human Type 2 Phosphatidic Acid Phosphohydrolases

1998 • 178 citations

Malignant effusions contain lysophosphatidic acid (LPA)-like activity

1998 • 178 citations

EDG3 Is a Functional Receptor Specific for Sphingosine 1-Phosphate and Sphingosylphosphorylcholine with Signaling Characteristics Distinct from EDG1 and AGR16

1999 • 176 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.

1999 • 166 citations

Induction of Endothelial Cell Chemotaxis by Sphingosine 1-Phosphate and Stabilization of Endothelial Monolayer Barrier Function by Lysophosphatidic Acid, Potential Mediators of Hematopoietic Angiogenesis

1999 • 159 citations

Edg-6 as a Putative Sphingosine 1-Phosphate Receptor Coupling to Ca2+ Signaling Pathway

2000 • 154 citations

Lysophosphatidic acid possesses dual action in cellproliferation.

1994 • 151 citations

Human Na+-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant

1999 • 150 citations

Motility and invasion are differentially modulated by Rho family GTPases

2000 • 150 citations

Elevated levels and altered fatty acid composition of plasma lysophosphatidlycholine(lysoPC) in ovarian cancer patients

1997 • 148 citations

Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.

1999 • 147 citations

Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate

1999 • 147 citations

A Transfected m1 Muscarinic Acetylcholine Receptor Stimulates Adenylate Cyclase via Phosphatidylinositol Hydrolysis

1989 • 146 citations

Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.

1988 • 145 citations

Screening for Ovarian Cancer

1994 • 142 citations

Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells.

1990 • 138 citations

Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth.

1998 • 134 citations

Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

1998 • 132 citations

Production of Lysophosphatidic Acids by Lysophospholipase D in Human Follicular Fluids of In Vitro Fertilization Patients1

1999 • 128 citations

Naturally Occurring Analogs of Lysophosphatidic Acid Elicit Different Cellular Responses through Selective Activation of Multiple Receptor Subtypes

1998 • 124 citations

A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action.

1988 • 121 citations

Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

2000 • 121 citations

Edg-2/Vzg-1 Couples to the Yeast Pheromone Response Pathway Selectively in Response to Lysophosphatidic Acid

1998 • 118 citations

Epidemiology and risk assessment for ovarian cancer.

1998 • 118 citations

Lysophosphatidic Acid Stimulates the G-protein-coupled Receptor EDG-1 as a Low Affinity Agonist

1998 • 116 citations

Phorbol 12-Myristate 13-Acetate Stimulates Lysophosphatidic Acid Secretion from Ovarian and Cervical Cancer Cells but Not from Breast or Leukemia Cells

1998 • 113 citations

Lysophosphatidic acid-induced Ca2+ mobilization in human A431 cells: structure-activity analysis

1995 • 113 citations

Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner.

1999 • 110 citations

Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells.

1991 • 99 citations

Identification of Human OGR1, a Novel G Protein-Coupled Receptor That Maps to Chromosome 14

1996 • 98 citations

Lysophosphatidic Acid Induces Necrosis and Apoptosis in Hippocampal Neurons

1998 • 98 citations

Endothelial cell mitogenesis induced by LPA: Inhibition by thrombospondin-1 and thrombospondin-2

1997 • 96 citations

Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells.

1999 • 92 citations

Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells.

1986 • 90 citations

Effect of lysophospholipids on signaling in the human Jurkat T cell line

1995 • 88 citations

Sphingosine‐1‐phosphate modulates growth and adhesion of ovarian cancer cells

1999 • 87 citations

Intracellular calcium release mediated by two muscarinic receptor subtypes

1988 • 85 citations

The PLD superfamily: insights into catalysis

1999 • 84 citations

Inhibition of tumor invasion and metastasis by a novel lysophosphatidic acid (cyclic LPA)

1999 • 80 citations

The significance of urokinase-type plasminogen activator, its inhibitors, and its receptor in ascites of patients with epithelial ovarian cancer

1995 • 79 citations

Lysophosphatidic acid: A bioactive phospholipid with growth factor-like properties

1992 • 75 citations

Sequence, expression in Escherichia coli, and characterization of lysophospholipase II

1999 • 75 citations

Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells.

1996 • 75 citations

Cloning, Expression, and Catalytic Mechanism of Murine Lysophospholipase I

1997 • 73 citations

Life on the edg

1999 • 72 citations

Possible role of phospholipase D in cellular differentiation and apoptosis

1999 • 70 citations

Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.

1997 • 68 citations

Identification of lysophospholipid receptors in human platelets: the relation of two agonists, lysophosphatidic acid and sphingosine 1‐phosphate

2000 • 61 citations

N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors.

1996 • 57 citations

Biology of ovarian cancer

1997 • 56 citations

Characterization of a Receptor Subtype-Selective Lysophosphatidic Acid Mimetic

1998 • 52 citations

A Gonadotropin-Releasing Hormone-Responsive Phosphatase Hydrolyses Lysophosphatidic Acid within the Plasma Membrane of Ovarian Cancer Cells

2000 • 50 citations

A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization

1999 • 45 citations

Effects of Lysophosphatidic Acid on Proliferation and Cytosolic Ca++ of Human Adult Vascular Smooth Muscle Cells in Culture

1999 • 43 citations

Intercellular Signaling by Lysophosphatidate Recent Developments

1998 • 42 citations

Production of lysophosphatidic acid by lysophospholipase D in incubated plasma of spontaneously hypertensive rats and Wistar Kyoto rats

1999 • 40 citations

Epithelial ovarian cancer

1999 • 37 citations

Synthesis and Growth Inhibitory Properties of Glycosides of 1-O-Hexadecyl-2-O-methyl-sn-glycerol, Analogs of the Antitumor Ether Lipid ET-18-OCH₃ (Edelfosine)

1996 • 35 citations

Involvement of small GTPases Rho and Rac in the invasion of rat ascites hepatoma cells.

1999 • 33 citations

Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma

1999 • 33 citations

Structure/Activity Relationships in Lysophosphatidic Acid: The 2-Hydroxyl Moiety

1997 • 33 citations

An experimental model for ovarian tumor invasion of cultured mesothelial cell monolayer.

1994 • 29 citations

Purification, characterization, and inhibition by phosphatidic acid of lysophospholipase transacylase from rat liver.

1994 • 28 citations

Lysophosphatidic Acid: A Novel Phospholipid with Hormone- and Growth Factor-like Activities

1992 • 26 citations

Structure−Activity Relationships of Lysophosphatidic Acid: Conformationally Restricted Backbone Mimetics

1999 • 23 citations

Inositol trisphosphate mediates cloned muscarinic receptor‐activated conductances in transfected mouse fibroblast A9 L cells.

1990 • 22 citations

Lysophosphatidylcholine triggers intracellular calcium release and activation of non-selective cation channels in renal arterial smooth muscle cells

2000 • 20 citations

Tumor cell kinetics following antineoplastic ether phospholipid treatment.

1992 • 16 citations

Synthesis of ether-linked analogues of lysophosphatidate and their effect on the proliferation of human epithelial cancer cells in vitro.

1996 • 13 citations

Mechanism of Endothelium-Dependent Vasorelaxation Evoked by Lysophosphatidylcholine.

1998 • 9 citations

ChemInform Abstract: Synthesis and Growth Inhibitory Properties of Glycosides of 1‐O‐ Hexadecyl‐2‐O‐methyl‐sn‐glycerol, Analogues of the Antitumor Ether Lipid ET‐18‐OCH3 (Edelfosine).

1996 • 9 citations

Activation of human ovarian cancer cells: role of lipid factors in ascitic fluid

1995 • 8 citations

Synthesis of Alkyl Chain-Modified Ether Lipids and Evaluation of Their in Vitro Cytotoxicity

1995 • 7 citations

Relationship of cell survival, drug dose, and drug uptake after 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine treatment

1994 • 5 citations

A macrophage activating factor is present and active in the ascitic fluid of patients with ovarian cancer

1985 • 5 citations

Cytokinetic and morphologic differences in ovarian cancer cells treated with ET-18-OCH3 and the DNA-interacting agent, etoposide.

1997 • 5 citations

Lysophosphatidylcholine triggers intracellular calcium release and activation of non-selective cation channels in renal arterial smooth muscle cells

2000 • 4 citations