Helminth Infection Protects Mice from Anaphylaxis via IL-10-Producing B Cells

Hay fever, hygiene, and household size.

1989 • 4,910 citations

Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

2003 • 4,529 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications

1994 • 1,752 citations

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 • 1,733 citations

B cells regulate autoimmunity by provision of IL-10

2002 • 1,562 citations

Allergy, Parasites, and the Hygiene Hypothesis

2002 • 1,543 citations

The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms

1965 • 1,327 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

The immunobiology of schistosomiasis

2002 • 1,111 citations

Immune Regulation by helminth parasites: cellular and molecular mechanisms

2003 • 1,102 citations

Chronic Intestinal Inflammatory Condition Generates IL-10-Producing Regulatory B Cell Subset Characterized by CD1d Upregulation

2002 • 929 citations

Reciprocal regulation of polarized cytokine production by effector B and T cells

2000 • 817 citations

Prevention of Arthritis by Interleukin 10–producing B Cells

2003 • 816 citations

Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10

2000 • 721 citations

From Systemic T Cell Self-Reactivity to Organ-Specific Autoimmune Disease via Immunoglobulins

1999 • 689 citations

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES:Lessons from Studies with Rodent Models^*

1997 • 648 citations

Asthma: an epidemic of dysregulated immunity

2002 • 613 citations

Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni.

1991 • 542 citations

IL-10 and the Dangers of Immune Polarization: Excessive Type 1 and Type 2 Cytokine Responses Induce Distinct Forms of Lethal Immunopathology in Murine Schistosomiasis

2000 • 461 citations

Active anaphylaxis in IgE-deficient mice

1994 • 414 citations

Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia

1998 • 404 citations

Impaired Development of Th2 Cells in IL-13-Deficient Mice

1998 • 384 citations

The Pathogenesis of Schistosomiasis Is Controlled by Cooperating IL-10-Producing Innate Effector and Regulatory T Cells

2004 • 367 citations

IL-4 Induces Characteristic Th2 Responses Even in the Combined Absence of IL-5, IL-9, and IL-13

2002 • 343 citations

Long‐Term Treatment of Intestinal Helminths Increases Mite Skin‐Test Reactivity in Gabonese Schoolchildren

2004 • 339 citations

Impairment of Tetanus Toxoid-Specific Thl-like Immune Responses in Humans Infected with Schistosoma mansoni

1996 • 328 citations

Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease

2001 • 326 citations

IL-9-Deficient Mice Establish Fundamental Roles for IL-9 in Pulmonary Mastocytosis and Goblet Cell Hyperplasia but Not T Cell Development

2000 • 324 citations

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

1991 • 312 citations

Pathways of anaphylaxis in the mouse

2002 • 303 citations

Interleukin-10 inhibits antigen-induced cellular recruitment into the airways of sensitized mice.

1995 • 283 citations

An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen

2002 • 238 citations

Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis

2001 • 196 citations

CD4+ T Cell–mediated Granulomatous Pathology in Schistosomiasis Is Downregulated by a B Cell–dependent Mechanism Requiring Fc Receptor Signaling

1998 • 185 citations

Interleukin (IL)-4–independent Induction of Immunoglobulin (Ig)E, and Perturbation of T Cell Development in Transgenic Mice Expressing IL-13

1998 • 182 citations

Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG

1999 • 182 citations

Schistosoma mansoni Worms Induce Anergy of T Cells via Selective Up-Regulation of Programmed Death Ligand 1 on Macrophages

2004 • 181 citations

Targeted Disruption of the Leukotriene B4Receptor in Mice Reveals Its Role in Inflammation and Platelet-Activating Factor–Induced Anaphylaxis

2000 • 177 citations

IL-10 Regulates Liver Pathology in Acute MurineSchistosomiasis mansoniBut Is Not Required for Immune Down-Modulation of Chronic Disease

1998 • 168 citations

Antigen-initiated release of platelet-activating factor (PAF-acether) from mouse bone marrow-derived mast cells sensitized with monoclonal IgE.

1983 • 136 citations

The Prevalence of Parasite Infestation and House Dust Mite Sensitization in Gabonese Schoolchildren

2001 • 125 citations

IL-4 Exacerbates Anaphylaxis

2003 • 125 citations

Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo.

1997 • 123 citations

B-1 cell (CD5+B220+) outgrowth in murine schistosomiasis is genetically restricted and is largely due to activation by polylactosamine sugars.

1997 • 105 citations

Modulation of the allergic reactivity of slum children by helminthic infection

1993 • 98 citations

Regulation of T helper cell responses in experimental murine schistosomiasis by IL-10. Effect on expression of B7 and B7-2 costimulatory molecules by macrophages.

1994 • 96 citations

T-cell subpopulations in the development of atopic and contact allergy

2001 • 92 citations

FcεRI-expressing antigen-presenting cells: new players in the atopic game

1997 • 89 citations

IL-13 Overexpression Predisposes to Anaphylaxis Following Antigen Sensitization

2001 • 85 citations

Type 1 and type 2 cytokine-producing mouse CD4+ and CD8+ T cells in acuteSchistosoma mansoni infection

1998 • 83 citations

Immunoglobulin E–dependent Active Fatal Anaphylaxis in Mast Cell–deficient Mice

1998 • 49 citations

Endogenous IL‐10 regulates IFN‐γ and IL‐5 cytokine production and the granulomatous response in Schistosomiasis mansoni‐infected mice

1998 • 34 citations

Anti-IL-4 monoclonal antibody prevents antibiotics-induced active fatal anaphylaxis.

1997 • 25 citations

Collagen II-pulsed antigen-presenting cells genetically modified to secrete IL-4 down-regulate collagen-induced arthritis

2001 • 23 citations

In vivo Arming of Cutaneous Mast Cell Receptors by IgE Released from Macrophages

1989 • 8 citations