Novel insights into histamine H₂receptor biology

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Definition and Antagonism of Histamine H2-receptors

1972 • 2,284 citations

Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor

1983 • 1,548 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

The physiological action of β‐iminazolylethylamine

1910 • 867 citations

RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE

1966 • 762 citations

Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family

1989 • 647 citations

Distribution, properties, and functional characteristics of three classes of histamine receptor.

1990 • 579 citations

Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.

1988 • 533 citations

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

1989 • 522 citations

Structural basis of β‐adrenergic receptor function

1989 • 480 citations

G protein—coupled receptor kinases

1993 • 434 citations

Evidence for dual coupling of the murine luteinizing hormone receptor to adenylyl cyclase and phosphoinositide breakdown and Ca2+ mobilization. Studies with the cloned murine luteinizing hormone receptor expressed in L cells.

1992 • 371 citations

New approaches to the physiology of histamine.

1968 • 359 citations

Molecular pharmacological aspects of histamine receptors

1995 • 353 citations

Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

1995 • 285 citations

Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation

1991 • 273 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

Site-directed mutagenesis of m1 muscarinic acetylcholine receptors: conserved aspartic acids play important roles in receptor function.

1989 • 258 citations

Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.

1987 • 248 citations

Differential coupling of dopaminergic D2 receptors expressed in different cell types. Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in LtK- fibroblasts, hyperpolarization, and cytosolic-free Ca2+ concentration decrease in GH4C1 cells.

1990 • 235 citations

Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.

1996 • 235 citations

The effects of the H1 and H2 antihistamines on "allergic" histamine release and its inhibition by histamine.

1975 • 233 citations

Differential Regulation of G-protein-mediated Signaling by Chemokine Receptors

1996 • 195 citations

Thyrotropin activates both the cyclic AMP and the PIP2casades in CHO cells expressing the human cDNA of TSH receptor

1990 • 184 citations

Molecular cloning of the human histamine H2 receptor

1991 • 183 citations

Calcium oscillations and morphological transformations in single cultured gastric parietal cells

1991 • 168 citations

A Transfected m1 Muscarinic Acetylcholine Receptor Stimulates Adenylate Cyclase via Phosphatidylinositol Hydrolysis

1989 • 146 citations

Molecular basis for the interaction of histamine with the histamine H2 receptor.

1992 • 144 citations

Mechanisms of multifunctional signalling by G protein-linked receptors

1993 • 143 citations

Histamine responsiveness of isolated gastric glands

1980 • 139 citations

Histamine: mercurial messenger in the gut

1992 • 120 citations

EFFECT OF CIMETIDINE ON SURVIVAL AFTER GASTRIC CANCER

1988 • 117 citations

Tautomerism and the receptor action of histamine: a mechanistic model.

1976 • 109 citations

Site-Directed Mutagenesis of the Histamine H1 Receptor: Roles of Aspartic Acid107, Asparagine198 and Threonine194

1994 • 107 citations

Histamine and cyclic AMP in isolated canine parietal cells.

1979 • 104 citations

Effects of histamine on hippocampal pyramidal cells of the rat in vitro

1986 • 100 citations

Cloning and tissue expression of a rat histamine H2-receptor gene

1991 • 99 citations

Characterization of the binding domain of the beta-adrenergic receptor with the fluorescent antagonist carazolol. Evidence for a buried ligand binding site.

1990 • 97 citations

Pharmacological Characterization and Autoradiographic Localization of Histamine H₂ Receptors in Human Brain Identified with [¹²⁵I]Iodoaminopotentidine

1992 • 93 citations

Multiple signaling pathways of histamine H2 receptors

1989 • 88 citations

Localization of targets for anti-ulcer drugs in cells of the immune system

1992 • 88 citations

Expression of a cloned rat histamine H2 receptor mediating inhibition of arachidonate release and activation of cAMP accumulation.

1992 • 86 citations

Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.

1992 • 84 citations

Cell dynamics and differentiation of conditionally immortalized human intestinal epithelial cells

1997 • 81 citations

G proteins of the Gq family couple the H2 histamine receptor to phospholipase C.

1996 • 81 citations

Site-Directed Mutagenesis of the Histamine H1-Receptor Reveals a Selective Interaction of Asparagine207 with Subclasses of H1-Receptor Agonists

1994 • 78 citations

Multiple mechanisms of receptor-G protein signaling specificity

1995 • 78 citations

Effect of histamine on the growth of human gastrointestinal tumours: reversal by cimetidine.

1993 • 77 citations

Histamine receptors on submucous neurons in guinea pig colon

1993 • 74 citations

Cholecystokinin, carbachol, gastrin, histamine, and forskolin increase [Ca2+]i in gastric glands

1986 • 68 citations

Immunoregulatory T cells in man. Histamine-induced suppressor T cells are derived from a Leu 2+ (T8+) subpopulation distinct from that which gives rise to cytotoxic T cells.

1985 • 65 citations

Characterization of H2 histamine receptor: linkage to both adenylate cyclase and [Ca2+]i signaling systems

1992 • 64 citations

The Guinea Pig Histamine H2 Receptor: Gene Cloning, Tissue Expression and Chromosomal Localization of Its Human Counterpart

1995 • 62 citations

Factors Regulating Availability of Histamine at Tissue Receptors

1982 • 61 citations

Histamine increases cytosolic Ca2+ in HL-60 promyelocytes predominantly via H2 receptors with an unique agonist/antagonist profile and induces functional differentiation.

1992 • 60 citations

An update on histamine H3 receptors and gastrointestinal functions

1995 • 55 citations

Biochemical characterization of histamine-sensitive adenylate cyclase in mammalian brain

1977 • 51 citations

Submucosal reflexes: distension-evoked ion transport in the guinea pig distal colon

1992 • 47 citations

Cellular cyclic AMP in dispersed mucosal cells from guinea pig stomach

1978 • 46 citations

Pharmacological properties of histamine receptor subtypes.

1994 • 45 citations

Epidermal growth factor inhibits carbachol-stimulated canine parietal cell function via protein kinase C

1996 • 44 citations

Molecular and Functional Diversity of Histamine Receptor Subtypes

1995 • 44 citations

Reflections on the analytical pharmacology of histamine H2-receptor antagonists

1993 • 40 citations

Demonstration of histamine H2 receptors on human melanoma cells

1988 • 39 citations

Characterization of histamine receptors in isolated human cerebral arteries

1988 • 38 citations

Characterization of histamine receptors mediating the stimulation of cyclic AMP accumulation in rabbit cerebral cortical slices

1985 • 38 citations

Histamine H2 receptor activates adenylate cyclase and PLC via separate GTP-dependent pathways

1996 • 37 citations

G Protein-Controlled Signal Transduction Pathways and the Regulation of Cell Proliferation

1992 • 36 citations

Visualization of Agonist-Induced Internalization of Histamine H2 Receptors

1995 • 34 citations

The effects of histamine H2 receptor antagonists on melanogenesis and cellular proliferation in melanoma cells in culture

1991 • 33 citations

New activation model for the histamine H2 receptor, explaining the activity of the different classes of histamine H2 receptor agonists.

1993 • 32 citations

Cloning and structure-function of the H2 histamine receptor

1991 • 32 citations

Effect of mercaptopicolinic acid and of transaminase inhibitors on glycogen synthesis by rat hepatocytes

1979 • 30 citations

Localization of the Histamine H2-Receptor and Gene Transcripts in Rat Stomach: Back to Parietal Cells

1994 • 29 citations

Coexistence of histamine H1 and H2 receptors coupled to distinct signal transduction pathways in isolated intestinal muscle cells.

1993 • 29 citations

Role of histamine2 receptor in increased expression of rat gastric H(+)-K(+)-ATPase alpha-subunit induced by omeprazole

1993 • 26 citations

Neuronal histamine in the gut wall releasable by gastrin and cholecystokinin

1983 • 25 citations

The C Terminal Tail of the Histamine H₂ Receptor Contains Positive and Negative Signals Important for Signal Transduction and Receptor Down‐Regulation

1996 • 25 citations

H1 and H2 histamine receptors in human mammary carcinomas

1993 • 24 citations

Inhibition of tumor growth induced by histamine: In vivo and in vitro studies

1993 • 23 citations

Synaptic transmission in submucosal ganglia of guinea pig distal colon

1991 • 23 citations

The role of calcium in the cyclic AMP response to histamine in rabbit cerebral cortical slices

1987 • 22 citations

Presence of histamine H2-receptors on human gastric carcinoma cell line MKN-45 and their increase by retinoic acid treatment

1991 • 22 citations

Interaction between the two signal transduction systems of the histamine H2 receptor: desensitizing and sensitizing effects of histamine stimulation on histamine-dependent cAMP production in Chinese hamster ovary cells

1996 • 20 citations

Synthetic segments of the mammalian βAR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C

1987 • 18 citations

Allelic variations of the human histamine H2 receptor gene

1996 • 18 citations

Histamine receptors in adipose tissue: involvement of cyclic adenosine monophosphate and the H2-receptor in the lipolytic response to histamine in isolated canine fat cells.

1975 • 18 citations

Evaluation of the trophic effect of longterm treatment with the histamine H2 receptor antagonist loxtidine on rat oxyntic mucosa by differential counting of dispersed cells.

1994 • 16 citations

Regression of Melanoma Nodules in a Patient Treated With Ranitidine

1987 • 15 citations

Identification of the Promoter Region of the Human Histamine H2-Receptor Gene

1995 • 14 citations

Cholinergic and VIP-ergic pathways mediate histamine H2 receptor-induced cyclical secretion in the guinea pig colon

1995 • 14 citations

Homologous desensitization of histamine H2 receptors in the human gastric carcinoma cell line MKN-45

1993 • 13 citations

Histamine inhibits prostaglandin E2-stimulated rabbit duodenal bicarbonate secretion via H2 receptors and enteric nerves

1995 • 11 citations

Histamine binding to H2 receptors stimulates phospholipid methylation in mast cells

1982 • 10 citations

The gastric H3 receptor: a review.

1992 • 8 citations

Effect of mast cell products and histamine on the proliferative behaviour of human melanoma and carcinoma cells in vitro

1993 • 6 citations

Mechanical responses of cultured pre- and neonatal myocytes

1979 • 5 citations

Construction of a Novel Bifunctional Biogenic Amine Receptor by Two Point Mutations of the H2-Histamine Receptor

1995 • 4 citations

[Solubilization, purification and molecular characterization of H2 histamine receptor from human tumoral gastric cells HGT-1].

1991 • 3 citations

Characterization of the structural components of the H2-histamine receptor involved in activation of adenylate cyclase and phospholipase C

1995 • 1 citations

Histamine H3 Receptors in the Brain: Potent and Selective Ligands

1989 • 1 citations