IL-10–producing T cells suppress immune responses in anergic tuberculosis patients

Harrison's Principles of Internal Medicine.

1988 • 11,687 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection.

1993 • 2,410 citations

Disseminated tuberculosis in interferon gamma gene-disrupted mice.

1993 • 1,982 citations

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways

1996 • 1,457 citations

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

1996 • 1,174 citations

Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.

1987 • 1,166 citations

An Outbreak of Tuberculosis with Accelerated Progression among Persons Infected with the Human Immunodeficiency Virus

1992 • 1,015 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates

1997 • 936 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

1996 • 869 citations

Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients

1998 • 812 citations

Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells.

1996 • 788 citations

Untitled

1996 • 780 citations

Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

1993 • 730 citations

Partial T cell signaling: Altered phospho-? and lack of zap70 recruitment in APL-induced T cell anergy

1994 • 608 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.

1994 • 551 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis.

1999 • 486 citations

Transplantation of Anergic Histoincompatible Bone Marrow Allografts

1999 • 448 citations

Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4 ⁺ T Cells

1996 • 438 citations

Maintenance of Human T Cell Anergy: Blocking of IL-2 Gene Transcription by Activated Rap1

1997 • 420 citations

Mice Deficient in CD4 T Cells Have Only Transiently Diminished Levels of IFN-γ, Yet Succumb to Tuberculosis

1999 • 401 citations

Blocked Ras Activation in Anergic CD4 ⁺ T Cells

1996 • 380 citations

IL-12 increases resistance of BALB/c mice to Mycobacterium tuberculosis infection.

1995 • 325 citations

Association of an HLA-DQ Allele With Clinical Tuberculosis

1998 • 247 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 245 citations

p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes

2000 • 241 citations

T cell-derived IL-10 antagonizes macrophage function in mycobacterial infection.

1997 • 228 citations

Serum concentrations of cytokines in patients with active tuberculosis (TB) and after treatment

1999 • 226 citations

In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in mice

1994 • 205 citations

B7 but not intercellular adhesion molecule-1 costimulation prevents the induction of human alloantigen-specific tolerance.

1993 • 205 citations

TNF-alpha and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages.

1999 • 204 citations

Induction of CD4+ T cell alloantigen-specific hyporesponsiveness by IL-10 and TGF-beta.

1999 • 195 citations

Increased Antimycobacterial Immunity in Interleukin-10-Deficient Mice

1999 • 188 citations

Early Emergence of CD8⁺T Cells Primed for Production of Type 1 Cytokines in the Lungs ofMycobacterium tuberculosis-Infected Mice

1999 • 181 citations

TNF-α and IL-10 Modulate the Induction of Apoptosis by Virulent Mycobacterium tuberculosis in Murine Macrophages

1999 • 154 citations

Induction of CD4+ T Cell Alloantigen-Specific Hyporesponsiveness by IL-10 and TGF-β

1999 • 154 citations

Cytokine Profiles for Peripheral Blood Lymphocytes from Patients with Active Pulmonary Tuberculosis and Healthy Household Contacts in Response to the 30-Kilodalton Antigen ofMycobacterium tuberculosis

1998 • 148 citations

Identification and Characterization of Protective T Cells in hsp65 DNA-Vaccinated andMycobacterium tuberculosis-Infected Mice

1998 • 146 citations

Anergic T cells act as suppressor cellsin vitro andin vivo

1999 • 144 citations

Interleukin 10–Mediated Immunosuppression by a Variant CD4 T Cell Epitope of Plasmodium falciparum

1999 • 122 citations

Cytokine function during mycobacterial and schistosomal antigen-induced pulmonary granuloma formation. Local and regional participation of IFN-gamma, IL-10, and TNF.

1995 • 109 citations

Anergy and Cytokine-Mediated Suppression as Distinct Superantigen-Induced Tolerance Mechanisms in Vivo

1999 • 105 citations

CD4(+) T cells tolerized ex vivo to host alloantigen by anti-CD40 ligand (CD40L:CD154) antibody lose their graft-versus-host disease lethality capacity but retain nominal antigen responses.

1998 • 98 citations

Characterization of HumanMycobacterium bovisBacille Calmette-Guérin-Reactive CD8⁺T Cells

1999 • 96 citations

Role of Cytokines in Tuberculosis

1993 • 86 citations

Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.

1996 • 85 citations

Corticosteroids in Tuberculosis

1996 • 75 citations

Defective TCR-mediated signaling in anergic T cells.

1995 • 70 citations

Endogenously produced IL-12 is required for the induction of protective T cells during Mycobacterium avium infections in mice.

1995 • 65 citations

Th2 biased immune response in cases with activeMycobacterium tuberculosisinfection and tuberculin anergy

1998 • 50 citations

The death and resurrection of tuberculosis

1999 • 42 citations

Th2 biased immune response in cases with active Mycobacterium tuberculosis infection and tuberculin anergy

1998 • 28 citations