Murine CTLA4-IgG Treatment Inhibits Airway Eosinophilia and Hyperresponsiveness and Attenuates IgE Upregulation in a Murine Model of Allergic Asthma

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

1995 • 2,090 citations

Humanization of an anti-p185HER2 antibody for human cancer therapy.

1992 • 1,867 citations

Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy

1992 • 1,290 citations

A new member of the immunoglobulin superfamily—CTLA-4

1987 • 1,214 citations

Immunosuppression in Vivo by a Soluble Form of the CTLA-4 T Cell Activation Molecule

1992 • 820 citations

T cells and eosinophils in the pathogenesis of asthma

1992 • 585 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 334 citations

CTLA4 mediates antigen-specific apoptosis of human T cells.

1995 • 331 citations

Pivotal role of the B7:CD28 pathway in transplantation tolerance and tumor immunity

1994 • 294 citations

Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma

1993 • 259 citations

Effects of glucocorticosteroids on inflammatory cells relevant to their therapeutic applications in asthma.

1990 • 196 citations

Development of airway hyperresponsiveness is dependent on interferon-gamma and independent of eosinophil infiltration.

1997 • 191 citations

Effect of corticosteroids on airway hyperresponsiveness.

1990 • 141 citations

Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model.

1996 • 139 citations

Transient production of proteins using an adenovirus transformed cell line

1990 • 129 citations

CTLA-4 ligands are required to induce an in vivo interleukin 4 response to a gastrointestinal nematode parasite.

1994 • 111 citations

Bronchoconstriction and airway hyperresponsiveness after ovalbumin inhalation in sensitized mice

1995 • 105 citations

Immunoadhesins: principles and applications

1996 • 100 citations

Expression and functional properties of mouse B7/BB1 using a fusion protein between mouse CTLA4 and human gamma 1.

1993 • 95 citations

Induction of Adjuvant-Independent IgE Responses in Inbred Mice: Primary, Secondary, and Persistent IgE Responses to Ovalbumin and Ovomucoid

1981 • 94 citations

Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain.

1995 • 93 citations

Chairman's Summary

1990 • 82 citations

Induction and reversal of long-lived specific unresponsiveness to a T-dependent antigen following CTLA4Ig treatment.

1995 • 70 citations

Effect of dexamethasone and endogenous corticosterone on airway hyperresponsiveness and eosinophilia in the mouse

1996 • 65 citations

Techniques for drug delivery to the airways, and the assessment of lung function in animal models

1992 • 57 citations

IgE receptor-positive non-B/non-T cells dominate the production of interleukin 4 and interleukin 6 in immunized mice.

1995 • 36 citations

Expression and Functional Analysis of Murine B7 Delineated by a Novel Monoclonal Antibody

1994 • 25 citations

CD80 (B7-1) and CD86 (B7-2): Potential targets for immunotherapy?

1995 • 21 citations

Production of interleukin-4 and interferon-gamma by TCR-V beta-expressing T-cell subsets in allergen-sensitized mice.

1996 • 18 citations

Secondary IgE Responses In Vivo are Predominantly Generated Via γ1ɛ‐Double Positive B Cells

1994 • 12 citations

Blocking CD28/B7 with soluble competitors: Immunological phenotype of mCTLA4-Hγ1 transgenic mice

1995 • 3 citations