Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom☆☆☆★★★

Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy

1989 • 1,512 citations

Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response.

1983 • 727 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

A Controlled Trial of Immunotherapy in Insect Hypersensitivity

1978 • 705 citations

Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals.

1993 • 549 citations

Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures.

1995 • 533 citations

Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses.

1993 • 479 citations

Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin.

1983 • 441 citations

Human peripheral blood basophils primed by interleukin 3 (IL-3) produce IL-4 in response to immunoglobulin E receptor stimulation.

1993 • 391 citations

Treatment of cat allergy with T-cell reactive peptides.

1996 • 364 citations

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice.

1993 • 334 citations

Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro.

1996 • 312 citations

Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I.

1993 • 280 citations

Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety

1992 • 280 citations

Chemiluminescence immunoassay: an overview

1986 • 208 citations

Position Paper: Immunotherapy with Hymenoptera venoms

1993 • 193 citations

T cell epitope specificity in human allergic and nonallergic subjects to bee venom phospholipase A2.

1993 • 153 citations

Regulation of human basophil mediator release by cytokines. I. Interaction with antiinflammatory steroids.

1989 • 136 citations

Allergy to insect stings

1976 • 131 citations

Bee venom phospholipase A2‐specific T cell clones from human allergic and non‐allergic individuals: cytokine patterns change in response to the antigen concentration

1992 • 114 citations

High-level expression in Escherichia coli and rapid purification of enzymatically active honey bee venom phospholipase A2

1992 • 112 citations

The dominant self and the cryptic self: shaping the autoreactive T-cell repertoire

1991 • 109 citations

Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils

1996 • 99 citations

Type I skin reactivity to native and recombinant phospholipase A from honeybee venom is similar

1995 • 87 citations

Carbohydrate‐dependent, HLA class II‐restricted, human T cell response to the bee venom allergen phospholipase A2 in allergic patients

1995 • 73 citations

Induction and differential regulation of bee venom phospholipase A2–specific human IgE and IgG4 antibodies in vitro requires allergen-specific and nonspecific activation of T and B cells☆, ☆☆, ★, ★★

1997 • 67 citations

Epidemiology of clinical allergy

1993 • 63 citations

Regulation of IgE and IgG responses by allergen specific T-cell clones to bee venom phospholipase A in vitro

1994 • 61 citations

The intensity of T cell receptor engagement determines the cytokine pattern of human allergen‐specific T helper cells

1997 • 61 citations

Defective TCR stimulation in anergized type 2 T helper cells correlates with abrogated p56(lck) and ZAP-70 tyrosine kinase activities.

1997 • 55 citations

Immunotherapy with T‐cell‐reactive peptides derived from allergens

1994 • 50 citations

Chemiluminescence immunoassay

1985 • 49 citations

Allergen Dose Dependent Cytokine Production Regulates Specific Ige And Igg Antibody Production

1996 • 37 citations

Human monoclonal or polyclonal antibodies recognize predominantly discontinuous epitopes on bee venom phospholipase A2

1994 • 33 citations

Epidemiology of insect sting allergy.

1993 • 23 citations

Regulation of the Immune Response to Allergens by Immunosuppressive Allergenic Fragments

1988 • 21 citations

Ultra rush bee venom immunotherapy does not reduce cutaneous weal responses to bee venom and codeine phosphate

1995 • 20 citations

Production of Human Antibodies to Bee Venom Phospholipase A₂ in Vitro

1989 • 15 citations

Quantification of IgG and IgG4 antibodies to bee venom phospholipase A2 by competitive inhibition in ELISA

1989 • 14 citations

Influence of bee venom immunotherapy on degranulation and leukotriene generation in human blood basophils

1996 • 13 citations

Induction of Antigen-Specific Unresponsiveness with Synthetic Peptides: Specific Immunotherapy for Treatment of Allergic and Autoimmune Conditions

1995 • 12 citations

Regulation of the Cytokine Production of Allergen-Specific Human T-Cell Clones by the Allergen

1992 • 8 citations

Deleted Work

1955 • 0 citations

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