Bee venom phospholipase A2‐specific T cell clones from human allergic and non‐allergic individuals: cytokine patterns change in response to the antigen concentration

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Lymphokine Control of In Vivo Immunoglobulin Isotype Selection

1990 • 1,303 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Release of Infectious Epstein-Barr Virus by Transformed Marmoset Leukocytes

1973 • 960 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

Interleukin-4: a prototypic immunoregulatory lymphokine

1991 • 878 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells.

1986 • 797 citations

Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response.

1983 • 727 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Transforming growth factor beta specifically enhances IgA production by lipopolysaccharide-stimulated murine B lymphocytes.

1989 • 567 citations

Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni.

1991 • 542 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Crystal Structure of Bee-Venom Phospholipase A ₂ in a Complex with a Transition-State Analogue

1990 • 442 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures.

1988 • 359 citations

IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma.

1988 • 315 citations

Helper T-cell subsets in mouse leishmaniasis: induction, expansion and effector function

1991 • 286 citations

Regulation and biological function of helminth-induced cytokine responses

1991 • 260 citations

Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression.

1987 • 259 citations

Regulation and deregulation of human IgE synthesis

1990 • 254 citations

Regulation of IgG1 and IgE Production by Interleukin 4

1988 • 244 citations

The role of IL-5 in IgA B cell differentiation.

1988 • 240 citations

The Value of Immunotherapy with Venom in Children with Allergy to Insect Stings

1990 • 240 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

Hypothesis: A role for tumor necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis

1988 • 199 citations

A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization.

1987 • 196 citations

Simultaneous production of interleukin 2, interleukin 4 and interferon‐γ by activated human blood lymphocytes

1990 • 165 citations

Analysis of the cDNA for phospholipase A₂ from honeybee venom glands

1989 • 153 citations

Allergens of honey bee venom

1976 • 153 citations

Control of biologically active interleukin 2 messenger RNA formation in induced human lymphocytes.

1984 • 141 citations

Characterization of the specificity of peptide binding to four DR haplotypes.

1990 • 134 citations

Allergy to insect stings

1976 • 131 citations

Functional heterogeneity among human inducer T cell clones.

1988 • 131 citations

B cell activation: Three steps and their variations

1984 • 130 citations

Monoclonal antibodies reactive with the mouse interleukin 5 receptor.

1989 • 103 citations

Regulation of the immune response to peptide antigens: differential induction of immediate-type hypersensitivity and T cell proliferation due to changes in either peptide structure or major histocompatibility complex haplotype.

1991 • 72 citations

Evaluation of decline in serum venom-specific IgE as a criterion for stopping venom immunotherapy

1986 • 59 citations

Requirement for three signals in "T-independent" (lipopolysaccharide-induced) as well as in T-dependent B cell responses.

1982 • 57 citations

Differential T cell responses to Plasmodium chabaudi chabaudi in peripheral blood and spleens of C57BL/6 mice during infection.

1991 • 44 citations

An HLA-associated nonresponsiveness to melittin: A components of bee venom+

1990 • 42 citations

Serial studies on the functional affinity and heterogeneity of antibodies of different IgG subclasses to phospholipase A produced in response to bee-venom immunotherapy

1989 • 39 citations

Bee keepers' IgG and IgE antibody responses to bee venom studied by means of crossed radioimmunoelectrophoresis

1984 • 26 citations

Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2

1991 • 22 citations

Changes in IgG and IgE Antibody Levels to Bee Venom during Immunotherapy

1986 • 18 citations

Venom immunotherapy for stinging insect allergy

1987 • 17 citations

Production of Human Antibodies to Bee Venom Phospholipase A₂ in Vitro

1989 • 15 citations

Quantification of IgG and IgG4 antibodies to bee venom phospholipase A2 by competitive inhibition in ELISA

1989 • 14 citations

Immune Response to Bee Venom

1987 • 13 citations