Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts.

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

After Insulin Binds

1987 • 687 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

The Nature and Regulation of the Insulin Receptor: Structure and Function

1985 • 318 citations

Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

1984 • 299 citations

Antibodies to Purified Insulin Receptor Have Insulin-Like Activity

1978 • 222 citations

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 • 203 citations

One-step purification of mouse monoclonal antibodies from ascites fluid by hydroxylapatite chromatography

1985 • 192 citations

Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytes.

1987 • 181 citations

Insulin Receptors, Receptor Antibodies, and the Mechanism of Insulin Action

1981 • 170 citations

High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.

1987 • 151 citations

Protein kinase activity of the insulin receptor

1986 • 149 citations

Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells.

1988 • 145 citations

Characterization of an endogenous substrate of the insulin receptor in cultured cells.

1987 • 136 citations

The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins G_i and G_o

1987 • 126 citations

The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor.

1984 • 118 citations

Insulin Receptor Phosphorylation May Not Be a Prerequisite for Acute Insulin Action

1984 • 109 citations

Tyrosine A14 [125I]monoiodoinsulin: Preparation, Biologic Properties, and Long-term Stability

1981 • 105 citations

Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping

1988 • 90 citations

Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity.

1987 • 89 citations

Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells.

1987 • 84 citations

Insulin receptor monoclonal antibodies that mimic insulin action without activating tyrosine kinase

1989 • 76 citations

Insulin-stimulated phosphorylation of calmodulin by rat liver insulin receptor preparations.

1988 • 75 citations

Early events in insulin actions.

1986 • 74 citations

Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor

1987 • 68 citations

Regulation of insulin receptor kinase activity by insulin mimickers and an insulin antagonist

1983 • 64 citations

Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules.

1987 • 62 citations

Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor.

1987 • 56 citations

[62] Preparation of F(ab′)2 fragments from mouse IgG of various subclasses

1986 • 50 citations

Insulin and rabbit anti-insulin receptor antibodies stimulate additively the intrinsic receptor kinase activity.

1987 • 29 citations

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