Role of Insulin Receptor Dimerization Domains in Ligand Binding, Cooperativity, and Modulation by Anti-receptor Antibodies

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling

1994 • 282 citations

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

1998 • 253 citations

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 • 203 citations

A model for insulin binding to the insulin receptor

1994 • 199 citations

Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors

2001 • 157 citations

Ligand-binding properties of the two isoforms of the human insulin receptor.

1993 • 140 citations

Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells.

1985 • 128 citations

Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants.

1993 • 118 citations

The insulin receptor. Structural basis for high affinity ligand binding.

1987 • 117 citations

The Disulfide Bonds in the C-terminal Domains of the Human Insulin Receptor Ectodomain

1997 • 114 citations

The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras.

1990 • 104 citations

Isolation of functional alpha beta heterodimers from the purified human placental alpha 2 beta 2 heterotetrameric insulin receptor complex. A structural basis for insulin binding heterogeneity.

1987 • 99 citations

Mapping of an NH--terminal Ligand Binding Site of the Insulin Receptor by Alanine Scanning Mutagenesis

1995 • 94 citations

Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites.

1990 • 94 citations

Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor.

1994 • 90 citations

A region of the insulin receptor important for ligand binding (residues 450-601) is recognized by patients' autoimmune antibodies and inhibitory monoclonal antibodies.

1991 • 85 citations

Alanine-scanning Mutagenesis of a C-terminal Ligand Binding Domain of the Insulin Receptor α Subunit

1996 • 84 citations

Identification of Common Ligand Binding Determinants of the Insulin and Insulin-like Growth Factor 1 Receptors

1997 • 82 citations

Identification of determinants that confer ligand specificity on the insulin receptor.

1992 • 81 citations

Detection of a new hormone contact site within the insulin receptor ectodomain by the use of a novel photoreactive insulin.

1992 • 80 citations

Binding properties of chimeric insulin receptors containing the cysteine-rich domain of either the insulin-like growth factor I receptor or the insulin receptor related receptor

1991 • 76 citations

Specificity of Insulin and Insulin-like Growth Factor I Receptors Investigated using Chimeric Mini-Receptors

1999 • 64 citations

Insulin-dependent intermolecular subunit communication between isolated alpha beta heterodimeric insulin receptor complexes.

1987 • 57 citations

Expression and Characterization of a 70-kDa Fragment of the Insulin Receptor That Binds Insulin

1998 • 56 citations

Identification of a disulfide bridge connecting the α-subunits of the extracellular domain of the insulin receptor

1992 • 48 citations

Fusion of Insulin Receptor Ectodomains to Immunoglobulin Constant Domains Reproduces High-affinity Insulin Binding in Vitro

1996 • 45 citations

High affinity insulin binding by soluble insulin receptor extracellular domain fused to a leucine zipper

2000 • 41 citations

Purification and Properties of Insulin Receptor Ectodomain from Large-Scale Mammalian Cell Culture

1995 • 40 citations

Dimeric Fragment of the Insulin Receptor α-Subunit Binds Insulin with Full Holoreceptor Affinity

2001 • 38 citations

The Insulin Receptor: from Protein Sequence to Structure

1999 • 33 citations

A third fibronectin type III domain in the extracellular region of the insulin receptor family

1998 • 30 citations

Transmembrane domain interactions are necessary for negative cooperativity of the insulin receptor.

1994 • 28 citations

Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding

2000 • 27 citations

Members of the Insulin Receptor Family Contain Three Fibronectin Type III Domains

1999 • 25 citations

Monoclonal antibodies as probes of the structure and function of insulin receptors

1987 • 24 citations

Chimeric receptors indicate that phenylalanine 39 is a major contributor to insulin specificity of the insulin receptor

1994 • 18 citations