Distinct .alpha.-subunit structures of human insulin receptor A and B variants determine differences in tyrosine kinase activities

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Analysis of radioligand binding experiments

1985 • 1,247 citations

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

1985 • 665 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine.

1982 • 441 citations

Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons.

1979 • 422 citations

Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.

1990 • 401 citations

Functionally distinct insulin receptors generated by tissue-specific alternative splicing.

1990 • 356 citations

Demonstration of two subtypes of insulin-like growth factor receptors by affinity cross-linking.

1981 • 332 citations

Alternative splicing of human insulin receptor messenger RNA

1989 • 312 citations

Synthetic tyrosine polymers as substrates and inhibitors of tyrosine-specific protein kinases.

1984 • 246 citations

Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells.

1984 • 208 citations

Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

1986 • 203 citations

Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control.

1988 • 164 citations

EVIDENCE FROM RADIOLIGAND ASSAYS THAT SOMATOMEDIN-C AND INSULIN-LIKE GROWTH FACTOR-I ARE SIMILAR TO EACH OTHER AND DIFFERENT FROM OTHER SOMATOMEDINS1

1980 • 157 citations

The human cytomegalovirus major immediate early promoter can be trans-activated by adenovirus early proteins

1989 • 122 citations

Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity

1984 • 122 citations

Decreased tyrosine kinase activity of insulin receptor isolated from rat adipocytes rendered insulin-resistant by catecholamine treatment in vitro

1986 • 119 citations

Insulin activation of insulin receptor tyrosine kinase in intact rat adipocytes. An in vitro system to measure histone kinase activity of insulin receptors activated in vivo.

1986 • 97 citations

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells.

1987 • 97 citations

Tumor-promoting phorbol esters increase the Km of the ATP-binding site of the insulin receptor kinase from rat adipocytes.

1986 • 97 citations

Purification and characterization of the human brain insulin receptor.

1986 • 76 citations

Purification of the insulin receptor from human placental membranes

1979 • 46 citations

Insulin activates GTP binding to a 40 kDa protein in fat cells

1991 • 30 citations