Functional Properties of Two Naturally Occurring Isoforms of the Human Insulin Receptor in Chinese Hamster Ovary Cells*

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.

1987 • 403 citations

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.

1987 • 399 citations

Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity

1988 • 368 citations

Functionally distinct insulin receptors generated by tissue-specific alternative splicing.

1990 • 356 citations

Structure of the human insulin receptor gene and characterization of its promoter.

1989 • 349 citations

Alternative splicing of human insulin receptor messenger RNA

1989 • 312 citations

Tissue-Specific Expression of Two Alternatively Spliced Insulin Receptor mRNAs in Man

1989 • 308 citations

Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts.

1986 • 269 citations

Structural differences between insulin receptors in the brain and peripheral target tissues.

1983 • 265 citations

Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.

1988 • 236 citations

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.

1990 • 207 citations

The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation.

1987 • 179 citations

High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells.

1987 • 151 citations

Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects.

1988 • 144 citations

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

1990 • 130 citations

Expression of a functional human insulin receptor from a cloned cDNA in Chinese hamster ovary cells.

1985 • 128 citations

The Rat Insulin Receptor: Primary Structure and Conservation of Tissue-Specific Alternative Messenger RNA Splicing

1990 • 119 citations

A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.

1990 • 118 citations

Insulin binding and insulin-dependent phosphorylation of the insulin receptor solubilized from human erythrocytes.

1983 • 101 citations

Insulin receptors in isolated rat hepatocytes. Reassessment of binding properties and observations of the inactivation of insulin at 37 degrees C.

1978 • 101 citations

Defective internalization of insulin and its receptor in cells expressing mutated insulin receptors lacking kinase activity.

1987 • 97 citations

A domain of the insulin receptor required for endocytosis in rat fibroblasts.

1990 • 97 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone.

1988 • 92 citations

Oligosaccharide Heterogeneity of Insulin Receptors. Comparison of N-Linked Glycosylation of Insulin Receptors in Adipocytes and Brain*

1986 • 90 citations

Intrinsic differences of insulin receptor kinase activity in red and white muscle.

1986 • 85 citations

Biologic activities of naturally occurring human insulin receptor mutations. Evidence that metabolic effects of insulin can be mediated by a kinase-deficient insulin receptor mutant

1991 • 67 citations

An atypical insulin receptor with high affinity for insulin-like growth factors copurified with placental insulin receptors.

1986 • 54 citations

Functional Properties of a Naturally Occurring Trp¹²⁰⁰→ Ser¹²⁰⁰Mutation of the Insulin Receptor

1990 • 48 citations

Protein kinase activity of the insulin receptor in human circulating and cultured mononuclear cells

1983 • 44 citations

Structural differences between liver- and muscle-derived insulin receptors in rats.

1986 • 39 citations

Phosphorylation state and biological function of a mutant human insulin receptor Val996.

1990 • 36 citations

Mutation of Tyrosine Residues 1162 and 1163 of the Insulin Receptor Affects Hormone and Receptor Internalization

1990 • 31 citations

Heterogeneity of human liver, muscle, and adipose tissue insulin receptor

1988 • 26 citations

Insulin Action in Cells Expressing Truncated or Kinase-Defective Insulin Receptors: Dissection of Multiple Hormone-Signaling Pathways

1990 • 20 citations

Analysis of insulin receptors on human lymphoblastoid cell lines by flow cytometry

1984 • 20 citations