Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing

Morpholino antisense oligomers: the case for an RNase H-independent structural type

1999 • 635 citations

Systemically delivered antisense oligomers upregulate gene expression in mouse tissues

2002 • 296 citations

Antisense-induced exon skipping restores dystrophin expression in DMD patient derived muscle cells

2001 • 282 citations

Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids.

1996 • 229 citations

Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs

2001 • 209 citations

Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides

1999 • 208 citations

Induction of endogenous Bcl-xS through the control of Bcl-x pre-mRNA splicing by antisense oligonucleotides

1999 • 200 citations

MOLECULAR GENETIC PROFILING OF GLEASON GRADE 4/5 PROSTATE CANCERS COMPARED TO BENIGN PROSTATIC HYPERPLASIA

2001 • 189 citations

The spectrum of cystic fibrosis mutations

1992 • 187 citations

Cellular Response to an Antisense-mediated Shift of Bcl-x Pre-mRNA Splicing and Antineoplastic Agents

2002 • 176 citations

Modification of Alternative Splicing of Bcl-x Pre-mRNA in Prostate and Breast Cancer Cells

2001 • 161 citations

Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic patients

2000 • 155 citations

Correction of Aberrant Splicing of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Gene by Antisense Oligonucleotides

1999 • 148 citations

Altered ratios of alternatively spliced long and short γ2 subunit mRNAs of the γ-amino butyrate type A receptor in prefrontal cortex of schizophrenics

1998 • 138 citations

Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus

1998 • 128 citations

Correction of Alternative Splicing of Tau in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17

2001 • 116 citations

A Unique Folate Hydrolase, Prostate-Specific Membrane Antigen (PSMA): A Target For Immunotherapy?

2001 • 92 citations

Antisense Morpholino Oligonucleotide Analog Induces Missplicing of C-mycmRNA

1999 • 89 citations

Aberrant Splicing in the PKD2 Gene as a Cause of Polycystic Kidney Disease

1999 • 87 citations

Identification of Intron and Exon Sequences Involved in Alternative Splicing of Insulin Receptor Pre-mRNA

1998 • 82 citations

Antisense-induced exon skipping and synthesis of dystrophin in the mdx mouse

2000 • 77 citations

Repair of a Splicing Defect in Erythroid Cells from Patients with β-Thalassemia/HbE Disorder

2002 • 76 citations

IL-5 and IL-5 receptor in asthma

1997 • 70 citations

Restoration of Human β-Globin Gene Expression in Murine and Human IVS2–654 Thalassemic Erythroid Cells by Free Uptake of Antisense Oligonucleotides

2002 • 67 citations

Overexpression of the Oncofetal Fn Variant Containing the EDA Splice-in Segment in the Dermal–Epidermal Junction of Psoriatic Uninvolved Skin

2000 • 66 citations

Altered GABA_A Receptor Subunit and Splice Variant Expression in Rats Treated With Chronic Intermittent Ethanol

2001 • 56 citations

A novel A–>G mutation in intron I of the hepatic lipase gene leads to alternative splicing resulting in enzyme deficiency.

1996 • 53 citations

Deletion of Individual Exons and Induction of Soluble Murine Interleukin-5 Receptor-α Chain Expression through Antisense Oligonucleotide-Mediated Redirection of Pre-mRNA Splicing

2000 • 52 citations

Modification of Alternative Splicing by Antisense Oligonucleotides as a Potential Chemotherapy for Cancer and Other Diseases

2001 • 51 citations

High-level expression of hemoglobin A in human thalassemic erythroid progenitor cells following lentiviral vector delivery of an antisense snRNA

2002 • 50 citations

Polycystic kidney disease: In danger of being X-rated?

2001 • 19 citations

Genotyping:Insulin receptor variant forms and Type 2 diabetes mellitus

2000 • 17 citations