Insulin-like Growth Factor Expression in Human Cancer Cell Lines

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1987 • 11,491 citations

Basic Methods in Molecular Biology

1986 • 3,284 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

1987 • 663 citations

The Nature and Regulation of the Receptors for Insulin-Like Growth Factors

1985 • 639 citations

Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts.

1994 • 527 citations

The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo.

1995 • 385 citations

Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors.

1994 • 310 citations

Two insulin-like growth factor I messenger RNAs are expressed in human liver.

1986 • 260 citations

Insulin-like growth factor-I can mediate autocrine proliferation of human small cell lung cancer cell lines in vitro.

1988 • 247 citations

Insulin-like growth factor II mRNA expression in human breast cancer.

1988 • 245 citations

An antibody to the receptor for insulin-like growth factor I inhibits the growth of MCF-7 cells in tissue culture

1987 • 155 citations

An alternatively spliced human insulin-like growth factor-I transcript with hepatic tissue expression that diverts away from the mitogenic IBE1 peptide.

1995 • 110 citations

The molecular and cellular biology of insulin-like growth factor II

1992 • 100 citations

Serum "big insulin-like growth factor II" from patients with tumor hypoglycemia lacks normal E-domain O-linked glycosylation, a possible determinant of normal propeptide processing.

1993 • 99 citations

Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line.

1992 • 96 citations

Purification and Characterization of a Unique High Molecular Weight Form of Insulin-Like Growth Factor II

1987 • 90 citations

Role for membrane and secreted insulin-like growth factor-binding protein-2 in the regulation of insulin-like growth factor action in lung tumors

1994 • 88 citations

Biosynthesis of rat insulin-like growth factor II. I. Immunochemical demonstration of a approximately 20-kilodalton biosynthetic precursor of rat insulin-like growth factor II in metabolically labeled BRL-3A rat liver cells.

1985 • 62 citations

Production of immunoreactive insulin-like growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours

1990 • 54 citations

Production and Action of Insulin-like Growth Factor I/Somatomedin C in Primary Cultures of Fetal Lung Fibroblasts

1989 • 54 citations

Expression of Insulinlike Growth Factor (IGF) and IGF-Binding Protein Genes in Human Lung Tumor Cell Lines

1992 • 53 citations

Characterization of insulin-like growth factor I receptors and growth effects in human lung cancer cell lines

1992 • 46 citations

The identification of O-glycosylated precursors of insulin-like growth factor II.

1992 • 44 citations

Production of gastrin-releasing peptide by a non-small cell lung carcinoma cell line adapted to serum-free and growth factor-free conditions.

1994 • 42 citations

Insulin-like growth factor II mediates epidermal growth factor-induced mitogenesis in cervical cancer cells.

1995 • 41 citations

Binding Specificities and Transducing Function of the Different Molecular Weight Forms of Insulin-Like Growth Factor-II (IGF-II) on IGF-I Receptors*

1991 • 39 citations

Production of insulin-like growth factor binding proteins by small-cell lung cancer cell lines

1989 • 27 citations

Characterization of Insulin-like Growth Factor II Receptors in Human Small Cell Lung Cancer Cell Lines

1993 • 20 citations