Functional Reconstitution of Insulin Receptor Binding Site from Non-binding Receptor Fragments

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

The Preparation of Subtilisin-modified Ribonuclease and the Separation of the Peptide and Protein Components

1959 • 632 citations

Structure and function of the type 1 insulin-like growth factor receptor

2000 • 602 citations

The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling

1994 • 282 citations

Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor

1998 • 253 citations

A model for insulin binding to the insulin receptor

1994 • 199 citations

On the tertiary structure of the extracellular domains of the epidermal growth factor and insulin receptors

1987 • 145 citations

Quaternary Structure of the Insulin-Insulin Receptor Complex

1999 • 129 citations

Signaling-competent receptor chimeras allow mapping of major insulin receptor binding domain determinants.

1993 • 118 citations

The Disulfide Bonds in the C-terminal Domains of the Human Insulin Receptor Ectodomain

1997 • 114 citations

Receptor-Ligand Interactions

1992 • 103 citations

Insulin and epidermal growth factor receptors contain the cysteine repeat motif found in the tumor necrosis factor receptor

1995 • 102 citations

Alanine Scanning Mutagenesis of a Type 1 Insulin-like Growth Factor Receptor Ligand Binding Site

2001 • 92 citations

Cross-linking of a B25 azidophenylalanine insulin derivative to the carboxyl-terminal region of the alpha-subunit of the insulin receptor. Identification of a new insulin-binding domain in the insulin receptor.

1994 • 90 citations

Alanine-scanning Mutagenesis of a C-terminal Ligand Binding Domain of the Insulin Receptor α Subunit

1996 • 84 citations

Identification of determinants that confer ligand specificity on the insulin receptor.

1992 • 81 citations

Changing the insulin receptor to possess insulin-like growth factor I ligand specificity

1990 • 70 citations

Specificity of Insulin and Insulin-like Growth Factor I Receptors Investigated using Chimeric Mini-Receptors

1999 • 64 citations

Expression and Characterization of a 70-kDa Fragment of the Insulin Receptor That Binds Insulin

1998 • 56 citations

A Novel Human Insulin Receptor Gene Mutation Uniquely Inhibits Insulin Binding Without Impairing Posttranslational Processing

1994 • 48 citations

Single-Molecule Imaging of Human Insulin Receptor Ectodomain and Its Fab Complexes

1999 • 41 citations

Role of Insulin Receptor Dimerization Domains in Ligand Binding, Cooperativity, and Modulation by Anti-receptor Antibodies

2002 • 40 citations

Dimeric Fragment of the Insulin Receptor α-Subunit Binds Insulin with Full Holoreceptor Affinity

2001 • 38 citations

The Insulin Receptor: from Protein Sequence to Structure

1999 • 33 citations

Insulin binding changes the interface region between .alpha. subunits of the insulin receptor

1989 • 21 citations

Exon 11 enhances insulin binding affinity and tyrosine kinase activity of the human insulin proreceptor.

1994 • 18 citations

Properties of an insulin receptor with an IGF‐1 receptor loop exchange in the cysteine‐rich region

2000 • 17 citations

Analysis of the Human Insulin Receptor

1992 • 3 citations