Phospholipase D and cell signaling

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Role of phospholipases in generating lipid second messengers in signal transduction ¹

1991 • 545 citations

G-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils.

1992 • 252 citations

Recent insights in phosphatidylinositol signaling

1990 • 245 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Tumor necrosis factor induces rapid production of 1'2'diacylglycerol by a phosphatidylcholine-specific phospholipase C.

1991 • 188 citations

Phospholipase D in cell signalling and its relationship to phospholipase C

1991 • 172 citations

Phospholipase C-mediated hydrolysis of phosphatidlycholine is an important step in PDGF-stimulated DNA synthesis

1990 • 163 citations

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

1992 • 160 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

1992 • 139 citations

Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5'-O-(3-thiotriphosphate). Activation is calcium dependent and requires protein factors in both the plasma membrane and cytosol.

1991 • 134 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Existence of cytosolic phospholipase D. Identification and comparison with membrane-bound enzyme

1991 • 120 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Receptor-coupled phospholipase D and its inhibition

1991 • 119 citations

Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.

1990 • 117 citations

Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase.

1992 • 115 citations

Phospholipase D activation by platelet-activating factor, leukotriene B4, and formyl-methionyl-leucyl-phenylalanine in rabbit neutrophils. Phospholipase D activation is involved in enzyme release.

1991 • 115 citations

An indirect pathway of receptor-mediated 1,2-diacylglycerol formation in mast cells. I. IgE receptor-mediated activation of phospholipase D.

1990 • 109 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Role of phospholipase D-derived diradylglycerol in the activation of the human neutrophil respiratory burst oxidase. Inhibition by phosphatidic acid phosphohydrolase inhibitors.

1992 • 105 citations

Synergistic activation of phospholipase D by protein kinase C- and G-protein-mediated pathways in streptolysin O-permeabilized HL60 cells

1992 • 104 citations

Identification of phosphatidylcholine-selective and phosphatidylinositol-selective phospholipases D in Madin-Darby canine kidney cells.

1992 • 103 citations

Complement C5a activation of phospholipase D in human neutrophils. A major route to the production of phosphatidates and diglycerides.

1990 • 101 citations

Phospholipid metabolism in bradykinin-stimulated human fibroblasts. II. Phosphatidylcholine breakdown by phospholipases C and D; involvement of protein kinase C

1991 • 100 citations

Angiotensin II-induced phosphatidylcholine hydrolysis in cultured vascular smooth-muscle cells. Regulation and localization

1991 • 98 citations

Multiple sources of sn-1,2-diacylglycerol in platelet-derived-growth-factor-stimulated Swiss 3T3 fibroblasts. Evidence for activation of phosphoinositidase C and phosphatidylcholine-specific phospholipase D

1991 • 97 citations

Phorbol ester treatment of intact rabbit platelets greatly enhances both the basal and guanosine 5′-[γ-thio]triphosphate-stimulated phospholipase D activities of isolated platelet membranes. Physiological activation of phospholipase D may be secondary to activation of phospholipase C

1990 • 90 citations

Elevated cytosolic Ca2+ activates phospholipase D in human platelets

1991 • 90 citations

Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis

1992 • 88 citations

Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.

1991 • 87 citations

Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.

1992 • 84 citations

Stimulation of insulin release by phospholipase D. A potential role for endogenous phosphatidic acid in pancreatic islet function

1990 • 75 citations

Activation of multiple mechanisms including phospholipase D by endothelin-1 in rat aorta

1992 • 72 citations

Differential regulation of phosphoinositide and phosphatidylcholine hydrolysis by protein kinase C-beta 1 overexpression. Effects on stimulation by alpha-thrombin, guanosine 5'-O-(thiotriphosphate), and calcium.

1992 • 72 citations

Thrombin stimulation of human endothelial cell phospholipase D activity. Regulation by phospholipase C, protein kinase C, and cyclic adenosine 3'5'-monophosphate.

1992 • 71 citations

Inhibition by phospholipids of the interaction between R-ras, rho, and their GTPase-activating proteins.

1989 • 66 citations

fMet-Leu-Phe-induced activation of phospholipase D in human neutrophils. Dependence on changes in cytosolic free Ca2+ concentration and relation with respiratory burst activation.

1991 • 66 citations

Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor

1991 • 62 citations

The role of calcium and protein kinase C in the IgE‐dependent activation of phosphatidylcholine‐specific phospholipase D in a rat mast (RBL 2H3) cell line

1992 • 60 citations

Phospholipase D activity in subcellular membranes of rat ventricular myocardium

1991 • 59 citations

Molecular species analysis of a product of phospholipase D activation. Phosphatidylethanol is formed from phosphatidylcholine in phorbol ester- and bradykinin-stimulated PC12 cells.

1992 • 56 citations

Epidermal growth factor‐induced hydrolysis of phosphatidylcholine by phospholipase D and phospholipase C in human dermal fibroblasts

1991 • 54 citations

Hepatocyte growth factor (HGF) mediates the sustained formation of 1,2‐diacylglycerol via phosphatidylcholine—phospholipase C in cultured rat hepatocytes

1992 • 53 citations

Mitogenic Action of Lysophosphatidic Acid

1991 • 50 citations

Stimulation of Phospholipase D Activity in Human Neuroblastoma (LA‐N‐2) Cells by Activation of Muscarinic Acetylcholine Receptors or by Phorbol Esters: Relationship to Phosphoinositide Turnover

1991 • 49 citations

Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine breakdown

1992 • 43 citations

Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C beta 1.

1991 • 41 citations

Endothelin stimulates phosphatidic acid formation in cultured rat mesangial cells: Role of a protein kinase C‐regulated phospholipase D

1992 • 41 citations

Calcium rather than protein kinase C is the major factor to activate phospholipase D in FMLP-stimulated rabbit peritoneal neutrophils. Possible involvement of calmodulin/myosin L chain kinase pathway.

1992 • 40 citations

Phospholipases C and D in mitogenic signal transduction

1992 • 39 citations

Differential effects of platelet-derived growth factor, serum and bombesin on phospholipase D-mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 fibroblasts

1992 • 38 citations

Direct relationship between intracellular calcium mobilization and phospholipase D activation in prostaglandin E-stimulated human erythroleukemia cells

1992 • 36 citations

Phospholipase D activation in human natural killer cells through the Kp43 and CD16 surface antigens takes place by different mechanisms. Involvement of the phospholipase D pathway in tumor necrosis factor alpha synthesis.

1992 • 36 citations

Activation of phospholipase D: a signaling system set in motion by perturbation of the T lymphocyte antigen receptor/CD3 complex.

1991 • 35 citations

Substrate specificity of neutral phospholipase D from rat brain studied by selective labeling of endogenous synaptic membrane phospholipids in vitro.

1992 • 35 citations

Norepinephrine-induced phosphatidylcholine hydrolysis by phospholipases D and C in rat tail artery

1992 • 34 citations

Activation of phospholipase D by α-thrombin or epidermal growth factor contributes to the formation of phosphatidic acid, but not to observed increases in 1,2-diacylglycerol

1992 • 33 citations

Activation of membrane protein kinase C by glucagon and Ca2+-mobilizing hormones in cultured rat hepatocytes. Role of phosphatidylinositol and phosphatidylcholine hydrolysis

1991 • 30 citations

Regulation of interleukin‐2 responses by phosphatidic acid

1992 • 27 citations

Rapid desensitization of vasopressin-stimulated phosphatidylinositol 4,5-bisphosphate and phosphatidylcholine hydrolysis questions the role of these pathways in sustained diacylglycerol formation in A10 vascular-smooth-muscle cells

1992 • 26 citations

Platelet-Activating Factor Mediates Phosphatidylcholine Hydrolysis by Phospholipase D in Human Endometrium1

1992 • 20 citations

Sequential degradation of choline phosphoglycerides by phospholipase D and phosphatidate phosphohydrolase in dibutyryl cAMP-differentiated U937 cells

1991 • 18 citations

Lipid A stimulates phospholipase D activity in rat mesangial cells via a G-protein

1992 • 18 citations

Platelet-Derived growth factor activates phospholipase D and chemotactic responses in vascular smooth muscle cells

1991 • 15 citations

Ethanolamine is released from glial cells in primary culture on stimulation with foetal calf serum and phorbol ester

1992 • 15 citations

Activation of phospholipase D by glyceraldehyde in isolated islet cells follows protein kinase C activation.

1992 • 14 citations

Regulation of diacylglycerol levels in carbachol-stimulated pancreatic acinar cells: Relationship to the breakdown of phosphatidylcholine and metabolism to phosphatidic acid

1992 • 13 citations

Vasopressin and phorbol ester-stimulated phosphatidylcholine metabolism in mesangial cells

1992 • 10 citations

Phospholipase D in the pancreatic islet: evidence suggesting the involvement of phosphatidic acid in signal transduction.

1991 • 4 citations

Activation of phospholipase D by glyceraldehyde in isolated islet cells follows protein kinase C activation

1992 • 4 citations