Decreased activities of phosphatidate phosphohydrolase and phospholipase D in ras and tyrosine kinase (fps) transformed fibroblasts.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Signaling through phosphatidylcholine breakdown.

1990 • 1,362 citations

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1986 • 999 citations

The regulation and cellular functions of phosphatidylcholine hydrolysis

1990 • 862 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Regulation of inositol phospholipid-specific phospholipase C isozymes.

1992 • 740 citations

[41] Use of vanadate as protein-phosphotyrosine phosphatase inhibitor

1991 • 583 citations

Lipid activation of protein kinase C.

1991 • 566 citations

Phosphatidate accumulation in hormone-treated hepatocytes via a phospholipase D mechanism.

1987 • 472 citations

Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

1993 • 377 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Normal rat cell lines deficient in nuclear thymidine kinase

1981 • 307 citations

The Effect of GTPase Activating Protein Upon Ras Is Inhibited by Mitogenically Responsive Lipids

1989 • 287 citations

Kinetic analysis of phospholipase A2 activity toward mixed micelles and its implications for the study of lipolytic enzymes

1975 • 278 citations

Plasma membrane fractions from rat liver contain a phosphatidate phosphohydrolase distinct from that in the endoplasmic reticulum and cytosol.

1991 • 271 citations

Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin

1992 • 266 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Activation of phospholipase D by protein kinase C. Evidence for a phosphorylation-independent mechanism.

1992 • 237 citations

Phosphatidic acid may stimulate membrane receptors mediating adenylate cyclase inhibition and phospholipid breakdown in 3T3 fibroblasts.

1987 • 219 citations

Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

1992 • 195 citations

Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil

1992 • 160 citations

A Cytoplasmic Protein Inhibits the GTPase Activity of H-Ras in a Phospholipid-Dependent Manner

1990 • 153 citations

Phosphatidic acid and not diacylglycerol generated by phospholipase D is functionally linked to the activation of the NADPH oxidase by FMLP in human neutrophils

1990 • 151 citations

Phosphatidate-dependent protein phosphorylation.

1991 • 149 citations

Growth factor stimulation of phospholipase C-gamma 1 activity. Comparative properties of control and activated enzymes.

1992 • 148 citations

Peroxides of vanadate induce activation of phospholipase D in HL-60 cells. Role of tyrosine phosphorylation.

1992 • 139 citations

Tumor necrosis factor alpha priming of phospholipase D in human neutrophils

1991 • 129 citations

Hydrolysis of phosphonate esters catalyzed by 5'-nucleotide phosphodiesterase

1975 • 123 citations

Dissociation of protein kinase C activation and sn-1,2-diacylglycerol formation. Comparison of phosphatidylinositol- and phosphatidylcholine-derived diglycerides in alpha-thrombin-stimulated fibroblasts.

1991 • 120 citations

Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis.

1990 • 117 citations

Rapid protein kinase C-dependent activation of phospholipase D leads to delayed 1,2-diglyceride accumulation.

1990 • 110 citations

The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin

1992 • 107 citations

Evidence for a role of phosphatidylcholine-hydrolysing phospholipase C in the regulation of protein kinase C by ras and src oncogenes.

1990 • 103 citations

Epidermal growth factor increases sn-1,2-diacylglycerol levels and activates phospholipase D-catalysed phosphatidylcholine breakdown in Swiss 3T3 cells in the absence of inositol-lipid hydrolysis

1992 • 88 citations

The sustained second phase of hormone-stimulated diacylglycerol accumulation does not activate protein kinase C in GH3 cells.

1990 • 82 citations

Effects of sphingosine, albumin and unsaturated fatty acids on the activation and translocation of phosphatidate phosphohydrolases in rat hepatocytes

1992 • 69 citations

Kinetic analysis of yeast phosphatidate phosphatase toward Triton X-100/phosphatidate mixed micelles.

1990 • 59 citations

[55] Characterization and assay of phosphatidate phosphatase

1991 • 57 citations

A rapid assay for measuring the activity and the Mg2+ and Ca2+ requirements of phosphatidate phosphohydrolase in cytosolic and microsomal fractions of rat liver

1987 • 55 citations

Solubility characteristics of Micrococcus lysodeikticus membrane components in detergents and chaotropic salts analyzed by immunoelectrophoresis

1979 • 55 citations

Vasopressin-induced polyphosphoinositide and phosphatidylcholine degradation in fibroblasts. Temporal relationship for formation of phospholipase C and phospholipase D hydrolysis products.

1990 • 51 citations

Phospholipase C gamma complexes with ligand-activated platelet-derived growth factor receptors. An intermediate implicated in phospholipase activation

1991 • 47 citations

Differential pathways (phospholipase C and phospholipase D) of bradykinin-induced biphasic 1,2-diacylglycerol formation in non-transformed and K-ras-transformed NIH-3T3 fibroblasts. Involvement of intracellular Ca2+ oscillations in phosphatidylcholine breakdown

1992 • 43 citations

Role of GTPase activating protein in mitogenic signalling through phosphatidylcholine-hydrolysing phospholipase C.

1991 • 42 citations

Activation of phospholipase D by α-thrombin or epidermal growth factor contributes to the formation of phosphatidic acid, but not to observed increases in 1,2-diacylglycerol

1992 • 33 citations

Disappearance of diacylglycerol kinase translocation in ras-transformed cells

1988 • 32 citations

Bimodal distribution of phosphatidic acid phosphohydrolase in NG108–15 cells

1992 • 30 citations

Translocation to rat liver mitochondria of phosphatidate phosphohydrolase

1989 • 23 citations

Regulation of phosphatidic acid phosphohydrolase activity during stimulation of human polymorphonuclear leukocytes

1992 • 22 citations

Genetic definition of ras effector elements.

1991 • 19 citations

Identification of two cytosolic diacylglycerol kinase isoforms in rat brain, and in NIH-3T3 and ras-transformed fibroblasts

1990 • 19 citations

A high level of cell surface phosphatidylinositol‐specific phospholipase C activity is characteristic of growth‐arrested 3T3 fibroblasts but not of transformed variants

1992 • 17 citations

Phospholipase D activity in nontransformed and transformed fibroblasts

1992 • 11 citations

Delineation of functional determinants in the transforming protein of Fujinami sarcoma virus

1990 • 5 citations