Genetic dissection of antigen receptor induced-NF-?B activation

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

Toll-Like Receptors

2003 • 6,127 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 • 3,364 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

IKKε and TBK1 are essential components of the IRF3 signaling pathway

2003 • 2,536 citations

Unresponsiveness of MyD88-Deficient Mice to Endotoxin

1999 • 2,088 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

2001 • 2,027 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

2003 • 1,625 citations

Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation

2000 • 1,365 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling

2003 • 1,226 citations

Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes

2001 • 1,078 citations

The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal

1998 • 1,062 citations

An Essential Role for BAFF in the Normal Development of B Cells Through a BCMA-Independent Pathway

2001 • 1,048 citations

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

2002 • 1,028 citations

TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

2003 • 1,023 citations

Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4

2002 • 985 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

2000 • 978 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems

2002 • 873 citations

CD45: A Critical Regulator of Signaling Thresholds in Immune Cells

2003 • 849 citations

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

2002 • 844 citations

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

2002 • 844 citations

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2002 • 803 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

PI3K in lymphocyte development, differentiation and activation

2003 • 739 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex

2000 • 685 citations

BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

2002 • 674 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

2003 • 568 citations

Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins

2002 • 565 citations

Essential role for ZAP-70 in both positive and negative selection of thymocytes

1995 • 554 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

2003 • 548 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

2003 • 512 citations

BLNK

1998 • 501 citations

NF-κB Family of Transcription Factors: Central Regulators of Innate and Adaptive Immune Functions

2002 • 489 citations

Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

2000 • 473 citations

BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2

2002 • 468 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

Immunodeficiency in Protein Kinase Cβ-Deficient Mice

1996 • 444 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

GENETIC ANALYSIS OF B CELL ANTIGEN RECEPTOR SIGNALING

1999 • 432 citations

Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway

2001 • 409 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

2002 • 395 citations

The essential role of MEKK3 in TNF-induced NF-κB activation

2001 • 389 citations

JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

1999 • 384 citations

Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

2003 • 366 citations

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

2000 • 365 citations

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IκB kinases

1999 • 362 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

Lipid rafts and B-cell activation

2002 • 349 citations

Innate recognition of lipopolysaccharide by Toll-like receptor 4–MD-2

2004 • 330 citations

The MAGUK Family Protein CARD11 Is Essential for Lymphocyte Activation

2003 • 326 citations

Abnormal Development and Function of B Lymphocytes in Mice Deficient for the Signaling Adaptor Protein SLP-65

1999 • 321 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

Amplification of B Cell Antigen Receptor Signaling by a Syk/ITAM Positive Feedback Loop

2002 • 312 citations

CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

2003 • 309 citations

Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death

2001 • 305 citations

The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells

2000 • 302 citations

Essential role of Src-family protein tyrosine kinases in NF-κB activation during B cell development

2003 • 300 citations

Bruton's Tyrosine Kinase Is Required for Activation of Iκb Kinase and Nuclear Factor κb in Response to B Cell Receptor Engagement

2000 • 299 citations

Requirement for B Cell Linker Protein (BLNK) in B Cell Development

1999 • 298 citations

IL-1 Receptor-Associated Kinase Modulates Host Responsiveness to Endotoxin

2000 • 290 citations

The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin

2000 • 284 citations

A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation

2002 • 278 citations

Induction of T Helper Type 2 Immunity by a Point Mutation in the LAT Adaptor

2002 • 265 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Requirement for CARMA1 in Antigen Receptor-Induced NF-κB Activation and Lymphocyte Proliferation

2003 • 253 citations

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

1999 • 239 citations

Protein Kinase C β Controls Nuclear Factor κB Activation in B Cells Through Selective Regulation of the IκB Kinase α

2002 • 239 citations

PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex

2000 • 216 citations

Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation

2000 • 215 citations

Regulation of B-cell signal transduction by adaptor proteins

2002 • 208 citations

Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

1998 • 195 citations

Iκb Kinase α Is Essential for Mature B Cell Development and Function

2001 • 186 citations

Targeted disruption ofTraf5gene causes defects in CD40- and CD27-mediated lymphocyte activation

1999 • 185 citations

It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation

2002 • 183 citations

Lymphotoxin ॆ Receptor Induces Sequential Activation of Distinct NF-κB Factors via Separate Signaling Pathways

2003 • 171 citations

Syk Tyrosine Kinase Is Required for the Positive Selection of Immature B Cells into the Recirculating B Cell Pool

1997 • 163 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

Mice Lacking the CARD of CARMA1 Exhibit Defective B Lymphocyte Development and Impaired Proliferation of Their B and T Lymphocytes

2003 • 149 citations

PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

2003 • 135 citations

Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation

2003 • 135 citations

RP105 Is Associated With MD-1 and Transmits an Activation Signal in Human B Cells

1998 • 128 citations

Innate recognition of lipopolysaccharide by CD14 and toll-like receptor 4-MD-2: unique roles for MD-2

2003 • 128 citations

TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling

2003 • 123 citations

TIRP, a Novel Toll/Interleukin-1 receptor (TIR) Domain-containing Adapter Protein Involved in TIR Signaling

2003 • 114 citations

A Subclass of Ras Proteins That Regulate the Degradation of IκB

2000 • 103 citations

Aberrant TCR-mediated signaling in CD45-null thymocytes involves dysfunctional regulation of Lck, Fyn, TCR-zeta, and ZAP-70.

1997 • 102 citations

Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice

1995 • 84 citations

A new family of IKK-related kinases may function as IκB kinase kinases

2001 • 83 citations

Essential Role of NF-κB-Inducing Kinase in T Cell Activation Through the TCR/CD3 Pathway

2002 • 80 citations

Induction of the NF-κB Cascade by Recruitment of the Scaffold Molecule NEMO to the T Cell Receptor

2003 • 71 citations

The Death Domain Kinase RIP Protects Thymocytes from Tumor Necrosis Factor Receptor Type 2–induced Cell Death

2002 • 65 citations

Protein Kinase C-associated Kinase (PKK), a Novel Membrane-associated, Ankyrin Repeat-containing Protein Kinase

2001 • 61 citations

Contribution of BCAP to maintenance of mature B cells through c-Rel

2003 • 58 citations

Vav-1 and the IKKα Subunit of IκB Kinase Functionally Associate to Induce NF-κB Activation in Response to CD28 Engagement

2003 • 54 citations

From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-κB

2003 • 52 citations

Mucosa-associated lymphoid tissue lymphoma

2002 • 47 citations

Protein Kinase C-associated Kinase (PKK) Mediates Bcl10-independent NF-κB Activation Induced by Phorbol Ester

2002 • 45 citations

Deficiency of phospholipase C-γ1 impairs renal development and hematopoiesis

2001 • 43 citations

κB-Ras Binds to the Unique Insert within the Ankyrin Repeat Domain of IκBβ and Regulates Cytoplasmic Retention of IκBβ·NF-κB Complexes

2003 • 36 citations

p105·IκBγ and Prototypical IκBs Use a Similar Mechanism to Bind but a Different Mechanism to Regulate the Subcellular Localization of NF-κB

2002 • 34 citations

A Catalytically Inactive Form of Protein Kinase C-Associated Kinase/Receptor Interacting Protein 4, a Protein Kinase Cβ-Associated Kinase That Mediates NF-κB Activation, Interferes with Early B Cell Development

2003 • 21 citations