From antigen to activation: specific signal transduction pathways linking antigen receptors to NF-κB

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

2002 • 2,400 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

Constitutive Nuclear Factor κB Activity Is Required for Survival of Activated B Cell–like Diffuse Large B Cell Lymphoma Cells

2001 • 1,035 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma

2000 • 978 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase

1999 • 827 citations

The Apoptosis Inhibitor Gene API2 and a Novel 18q Gene,MLT, Are Recurrently Rearranged in the t(11;18)(q21;q21) Associated With Mucosa-Associated Lymphoid Tissue Lymphomas

1999 • 714 citations

Bcl10 Is Involved in t(1;14)(p22;q32) of MALT B Cell Lymphoma and Mutated in Multiple Tumor Types

1999 • 666 citations

Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice

1999 • 581 citations

Transcriptional regulation of the IL-2 gene

1995 • 579 citations

Signal Transduction Mediated by the T Cell Antigen Receptor: The Role of Adapter Proteins

2002 • 565 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

2000 • 523 citations

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1999 • 475 citations

BAFF/BLyS Receptor 3 Binds the B Cell Survival Factor BAFF Ligand through a Discrete Surface Loop and Promotes Processing of NF-κB2

2002 • 468 citations

Recruitment of the IKK Signalosome to the p55 TNF Receptor

2000 • 457 citations

Immunodeficiency in Protein Kinase Cβ-Deficient Mice

1996 • 444 citations

CD40 regulates the processing of NF-kappaB2 p100 to p52

2002 • 435 citations

Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway

2001 • 409 citations

Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti

2000 • 395 citations

JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection

1999 • 384 citations

Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32)

1999 • 383 citations

Two Pathways to NF-κB

2002 • 383 citations

IKKα controls formation of the epidermis independently of NF-κB

2001 • 357 citations

A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue

1999 • 354 citations

CARD11 and CARD14 Are Novel Caspase Recruitment Domain (CARD)/Membrane-associated Guanylate Kinase (MAGUK) Family Members that Interact with BCL10 and Activate NF-κB

2001 • 328 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells.

1993 • 306 citations

Bruton's Tyrosine Kinase Is Required for Activation of Iκb Kinase and Nuclear Factor κb in Response to B Cell Receptor Engagement

2000 • 299 citations

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

2000 • 291 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Protein Kinase C-θ Isoenzyme Selective Stimulation of the Transcription Factor Complex AP-1 in T Lymphocytes

1996 • 251 citations

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

1999 • 239 citations

Protein Kinase C β Controls Nuclear Factor κB Activation in B Cells Through Selective Regulation of the IκB Kinase α

2002 • 239 citations

A Novel Functional Interaction between Vav and PKCθ Is Required for TCR-Induced T Cell Activation

2000 • 226 citations

Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation

2000 • 215 citations

Signaling pathways are focused at specialized regions of the plasma membrane by scaffolding proteins of the MAGUK family

1999 • 212 citations

IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis

2001 • 208 citations

CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex

2002 • 206 citations

Carma1, a CARD‐containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF‐κB activation¹

2001 • 195 citations

Iκb Kinase α Is Essential for Mature B Cell Development and Function

2001 • 186 citations

Bimp1, a MAGUK Family Member Linking Protein Kinase C Activation to Bcl10-mediated NF-κB Induction

2001 • 182 citations

Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18.

1999 • 169 citations

CIPER, a Novel NF κB-activating Protein Containing a Caspase Recruitment Domain with Homology to Herpesvirus-2 Protein E10

1999 • 142 citations

CARD10 Is a Novel Caspase Recruitment Domain/Membrane-associated Guanylate Kinase Family Member That Interacts with BCL10 and Activates NF-κB

2001 • 140 citations

The Btk subfamily of cytoplasmic tyrosine kinases: structure, regulation and function

1995 • 139 citations

The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD28

2000 • 136 citations

mE10, a Novel Caspase Recruitment Domain-containing Proapoptotic Molecule

1999 • 120 citations

Protein kinase Cθ, a selective upstream regulator of JNK/SAPK and IL-2 promoter activation in Jurkat T cells

1999 • 113 citations

CLAP, a Novel Caspase Recruitment Domain-containing Protein in the Tumor Necrosis Factor Receptor Pathway, Regulates NF-κB Activation and Apoptosis

1999 • 111 citations

Bruton's Tyrosine Kinase Controls a Sustained Calcium Signal Essential for B Lineage Development and Function

1999 • 105 citations

c-E10 Is a Caspase-recruiting Domain-containing Protein That Interacts with Components of Death Receptors Signaling Pathway and Activates Nuclear Factor-κB

1999 • 81 citations

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

1998 • 77 citations

ZAP-70 and SLP-76 Regulate Protein Kinase C-θ and NF-κB Activation in Response to Engagement of CD3 and CD28

2001 • 74 citations

Synergistic Activation of NF-κB by Functional Cooperation between Vav and PKCθ in T Lymphocytes

2000 • 46 citations

SIGNALLING SCAFFOLDS AND ADAPTORS IN T‐CELL IMMUNITY

2002 • 22 citations