The diversity of immunological synapses

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node

2002 • 1,177 citations

Serial triggering of many T-cell receptors by a few peptide–MHC complexes

1995 • 1,143 citations

The Immunological Synapse

2001 • 987 citations

The Duration of Antigenic Stimulation Determines the Fate of Naive and Effector T Cells

1998 • 890 citations

Direct observation of ligand recognition by T cells

2002 • 802 citations

The Immunological Synapse of CTL Contains a Secretory Domain and Membrane Bridges

2001 • 796 citations

Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes

2002 • 707 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Structural Basis of Plasticity in T Cell Receptor Recognition of a Self Peptide-MHC Antigen

1998 • 685 citations

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

2002 • 597 citations

Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy

2003 • 480 citations

Imaging biochemistry inside cells

2001 • 453 citations

Recruitment of Nck by CD3ϵ Reveals a Ligand-Induced Conformational Change Essential for T Cell Receptor Signaling and Synapse Formation

2002 • 442 citations

Initiation of Signal Transduction through the T Cell Receptor Requires the Multivalent Engagement of Peptide/MHC Ligands

1998 • 379 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Synaptic pattern formation during cellular recognition

2001 • 346 citations

Staging and resetting T cell activation in SMACs

2002 • 343 citations

Degradation of T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic Stimulation

1997 • 316 citations

Costimulation and endogenous MHC ligands contribute to T cell recognition

2001 • 302 citations

Functional antigen-independent synapses formed between T cells and dendritic cells

2001 • 287 citations

Critical Role for Cd8 in T Cell Receptor Binding and Activation by Peptide/Major Histocompatibility Complex Multimers

2000 • 281 citations

Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy

2002 • 278 citations

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

2001 • 270 citations

Dynamic Polarization of the Microtubule Cytoskeleton during CTL-Mediated Killing

2002 • 257 citations

The Relationship of MHC-Peptide Binding and T Cell Activation Probed Using Chemically Defined MHC Class II Oligomers

2000 • 254 citations

T Cell Receptor–MHC Interactions up Close

2001 • 252 citations

ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse

2001 • 247 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells.

1984 • 230 citations

Cutting Edge: The Dendritic Cell Cytoskeleton Is Critical for the Formation of the Immunological Synapse

2001 • 213 citations

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

2002 • 212 citations

The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation

2001 • 189 citations

Dynamics of the immunological synapse: finding, establishing and solidifying a connection

2002 • 184 citations

Small splenic B cells that bind to antigen-specific T helper (Th) cells and face the site of cytokine production in the Th cells selectively proliferate: immunofluorescence microscopic studies of Th-B antigen-presenting cell interactions.

1994 • 168 citations

Imaging antigen-induced PI3K activation in T cells

2002 • 159 citations

Antigen-dependent and -independent Ca2+ Responses Triggered in T Cells by Dendritic Cells Compared with B Cells

1998 • 151 citations

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

2000 • 143 citations

Imaging Synapse Formation during Thymocyte Selection

2002 • 142 citations

Immature CD4+CD8+ Thymocytes Form a Multifocal Immunological Synapse with Sustained Tyrosine Phosphorylation

2002 • 138 citations

Cutting Edge: Quantitative Imaging of Raft Accumulation in the Immunological Synapse

2002 • 136 citations

In the Immune Synapse, ZAP-70 Controls T Cell Polarization and Recruitment of Signaling Proteins but Not Formation of the Synaptic Pattern

2002 • 125 citations

Dependence of T Cell Antigen Recognition on the Dimensions of an Accessory Receptor–Ligand Complex

1999 • 123 citations

CD8 Expression Allows T Cell Signaling by Monomeric Peptide-MHC Complexes

1998 • 119 citations

The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte–antigen-presenting cell interface

2000 • 117 citations

Serial TCR Engagement and Down-Modulation by Peptide:MHC Molecule Ligands: Relationship to the Quality of Individual TCR Signaling Events

1999 • 117 citations

Formation and function of the immunological synapse

2002 • 106 citations

TCR dynamics on the surface of living T cells

2001 • 76 citations

Signal extinction and T cell repolarization in T helper cell‐antigen‐presenting cell conjugates

1996 • 76 citations

The Immunological Synapse--a Multitasking System

2002 • 72 citations

ZAP-70 Association with T Cell Receptor ζ (TCRζ): Fluorescence Imaging of Dynamic Changes upon Cellular Stimulation

1998 • 64 citations

Quantifying signaling-induced reorientation of T cell receptors during immunological synapse formation

2002 • 59 citations

An evolutionary and structural perspective on T cell antigen receptor function

2003 • 59 citations

Imaging of T‐cell interactions with antigen presenting cells in culture and in intact lymphoid tissue

2002 • 56 citations

Cutting Edge: TCR Engagement and Triggering in the Absence of Large-Scale Molecular Segregation at the T Cell-APC Contact Site

2002 • 55 citations

T cell adhesion lowers the threshold for antigen detection

2003 • 54 citations

αβ T Cell Receptor Ligand-Specific Oligomerization Revisited

2001 • 47 citations

Formation of TCR dimers/trimers as a crucial step for T cell activation

1998 • 46 citations

Calcium responses elicited in human T cells and dendritic cells by cell–cell interaction and soluble ligands

1999 • 37 citations

Imaging T‐cell antigen recognition and comparing immunological and neuronal synapses

2001 • 31 citations