In the Immune Synapse, ZAP-70 Controls T Cell Polarization and Recruitment of Signaling Proteins but Not Formation of the Synaptic Pattern

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

LAT

1998 • 1,251 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

The Immunological Synapse

2001 • 987 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

LAT Palmitoylation

1998 • 837 citations

A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts

1998 • 708 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation

1998 • 625 citations

Selective modulation of protein kinase C-Θ during T-cell activation

1997 • 558 citations

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

1994 • 552 citations

Human Severe Combined Immunodeficiency Due to a Defect in ZAP-70, a T Cell Tyrosine Kinase

1994 • 516 citations

ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists

1995 • 510 citations

Wiskott-Aldrich Syndrome Protein-Deficient Mice Reveal a Role for WASP in T but Not B Cell Activation

1998 • 494 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Microtubules and signal transduction

1999 • 407 citations

Dynamic Actin Polymerization Drives T Cell Receptor–Induced Spreading

2001 • 404 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42.

1995 • 386 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Synaptic pattern formation during cellular recognition

2001 • 346 citations

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

2000 • 345 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

2000 • 295 citations

Receptor-directed focusing of lymphokine release by helper T cells

1988 • 284 citations

Spatial relationships of microtubule-organizing centers and the contact area of cytotoxic T lymphocytes and target cells.

1982 • 283 citations

Exclusion of CD43 from the Immunological Synapse Is Mediated by Phosphorylation-Regulated Relocation of the Cytoskeletal Adaptor Moesin

2001 • 270 citations

Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line

1998 • 269 citations

ERM-Dependent Movement of CD43 Defines a Novel Protein Complex Distal to the Immunological Synapse

2001 • 247 citations

Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism

1998 • 247 citations

Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells.

1991 • 241 citations

Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells.

1984 • 230 citations

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

2000 • 194 citations

The Membrane-Microfilament Linker Ezrin Is Involved in the Formation of the Immunological Synapse and in T Cell Activation

2001 • 189 citations

Role of ICAM-3 in the initial interaction of T lymphocytes and APCs

2002 • 171 citations

WASP Recruitment to the T Cell:APC Contact Site Occurs Independently of Cdc42 Activation

2001 • 153 citations

Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes

2000 • 143 citations

Internalization and Intracellular Fate of TCR-CD3 Complexes

2000 • 133 citations

Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

1998 • 121 citations

Superantigen-Induced T Cell:B Cell Conjugation Is Mediated by LFA-1 and Requires Signaling Through Lck, But Not ZAP-70

2001 • 104 citations

Fyn and ZAP-70 Are Required for Vav Phosphorylation in T Cells Stimulated by Antigen-presenting Cells

1998 • 101 citations

The area of attachment of cytotoxic T lymphocytes to their target cells shows high motility and polarization of actin, but not myosin.

1982 • 90 citations

Cutting Edge: In Vivo Identification of TCR Redistribution and Polarized IL-2 Production by Naive CD4 T Cells

2001 • 83 citations

Mutation of Tyrosines 492/493 in the Kinase Domain of ZAP-70 Affects Multiple T-cell Receptor Signaling Pathways

1996 • 72 citations

Differential Requirement of ZAP-70 for CD2-Mediated Activation Pathways of Mature Human T Cells

2000 • 48 citations

Differential Roles of Lck and Itk in T Cell Response to Antigen Recognition Revealed by Calcium Imaging and Electron Microscopy

2001 • 37 citations

Immunodeficiency Diseases

2021 • 6 citations