A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Production of high-titer helper-free retroviruses by transient transfection.

1993 • 2,280 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Dll4, a novel Notch ligand expressed in arterial endothelium

2000 • 522 citations

Notch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene

1996 • 497 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands.

1992 • 354 citations

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

1998 • 328 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)

1997 • 194 citations

A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors

1994 • 176 citations

Chronic exposure to retroviral vector encoded MGDF (mpl-ligand) induces lineage-specific growth and differentiation of megakaryocytes in mice

1995 • 162 citations

Monocytes express high amounts of Notch and undergo cytokine specific apoptosis following interaction with the Notch ligand, Delta-1

2000 • 134 citations

Expression of the Notch 3 intracellular domain in mouse central nervous system progenitor cells is lethal and leads to disturbed neural tube development

1996 • 120 citations

Transduction of Notch2 in feline leukemia virus-induced thymic lymphoma

1996 • 115 citations

Expression of notch receptors, notch ligands, and fringe genes in hematopoiesis

2000 • 108 citations