Limited effect of chromatin remodeling on Dβ-to-Jβ recombination in CD4+CD8+ thymocyte: implications for a new aspect in the regulation of TCR β gene recombination

Simplified mammalian DNA isolation procedure

1991 • 1,508 citations

Molecular cloning (2nd Ed)

1989 • 1,191 citations

A positive role for histone acetylation in transcription factor access to nucleosomal DNA

1993 • 1,116 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase

1995 • 612 citations

Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain.

1994 • 539 citations

Acetylation of histone H4 plays a primary role in enhancing transcription factor binding to nucleosomal DNA in vitro.

1996 • 469 citations

Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation.

1994 • 334 citations

A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination

2000 • 286 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

CD3ε-mediated signals rescue the development of CD4⁺CD8⁺ thymocytes in RAG-2^−/− mice in the absence of TCR β chain expression

1994 • 205 citations

Function of the TCRα Enhancer in αβ and γδ T Cells

1997 • 204 citations

A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.

1989 • 185 citations

Transcription of T cell receptor beta-chain genes is controlled by a downstream regulatory element.

1988 • 185 citations

T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.

1995 • 180 citations

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.

1996 • 179 citations

A novel, inducible and T cell-specific enhancer located at the 3′ end of the T cell receptor alpha locus.

1989 • 176 citations

A T-cell-specific transcriptional enhancer element 3' of C alpha in the human T-cell receptor alpha locus.

1989 • 165 citations

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1996 • 164 citations

Chromatin Remodeling by the T Cell Receptor (Tcr)-β Gene Enhancer during Early T Cell Development

2000 • 161 citations

CD3 components at the surface of pro‐T cells can mediate pre‐T cell development in vivo

1994 • 156 citations

TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.

1993 • 132 citations

T Cell Receptor (TCR)-β Gene Recombination: Dissociation from Cell Cycle Regulation and Developmental Progression During T Cell Ontogeny

1997 • 128 citations

In-frame TCR δ gene rearrangements play a critical role in the αβ/γδ T cell lineage decision

1995 • 122 citations

A Transcriptional Enhancer 3′ of C _β2 in the T Cell Receptor β Locus

1988 • 118 citations

Identification and functional characterization of the human T-cell receptor beta gene transcriptional enhancer: common nuclear proteins interact with the transcriptional regulatory elements of the T-cell receptor alpha and beta genes.

1990 • 117 citations

Intrathymic δ Selection Events in γδ Cell Development

1997 • 112 citations

Role of Different T Cell Receptors in the Development of Pre–T Cells

1997 • 108 citations

T Cell Receptor δ Gene Rearrangement and T Early α (TEA) Expression in Immature αβ LineageThymocytes: Implications for αβ/γδ Lineage Commitment

1996 • 96 citations

TCR gene recombination and alpha beta-gamma delta lineage divergence: productive TCR-beta rearrangement is neither exclusive nor preclusive of gamma delta cell development.

1996 • 88 citations

Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.

1994 • 85 citations

A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.

1993 • 81 citations

The Developmental Fate of T Cells Is Critically Influenced by TCRγδ Expression

1998 • 81 citations

Functional analysis of the murine T-cell receptor beta enhancer and characteristics of its DNA-binding proteins.

1990 • 75 citations

αβ Lineage‐committed thymocytes can be rescued by the γδ T cell receptor (TCR) in the absence of TCR β chain

1997 • 52 citations

Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusion

1998 • 44 citations

Definition of a T-Cell Receptor β Gene Core Enhancer of V(D)J Recombination by Transgenic Mapping

2000 • 44 citations

T Cell Development in TCRβ Enhancer-Deleted Mice: Implications for αβ T Cell Lineage Commitment and Differentiation

2000 • 37 citations

T Cell Receptor γ Gene Regulatory Sequences Prevent the Function of a Novel TCRγ/pTα Pre–T Cell Receptor

1998 • 37 citations

Efficient maturation of alpha beta lineage thymocytes to the CD4+CD8+ stage in the absence of TCR-beta rearrangement.

1995 • 36 citations

T-cell specific rearrangement of T-cell receptor beta transgenes in mice.

1990 • 33 citations

Correction: Crucial role of the pre-T-cell receptor α gene in development of αβ but not γ§ T cells

1995 • 10 citations

Functional expression of a human TCRβ gene in transgenic mice

1993 • 3 citations