The dawning era of polymer therapeutics

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

1986 • 6,585 citations

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.

1995 • 6,103 citations

Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and Inhibitors

1998 • 3,843 citations

A New Class of Polymers: Starburst-Dendritic Macromolecules

1985 • 3,744 citations

Effect of pegylation on pharmaceuticals

2003 • 3,176 citations

Drug Delivery and Targeting

2016 • 2,037 citations

Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications

2002 • 2,036 citations

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Carbohydrate-Specific Receptors of the Liver

1982 • 1,895 citations

Lysosomotropic agents

1974 • 1,887 citations

Ligand-targeted therapeutics in anticancer therapy

2002 • 1,592 citations

Chemistry for peptide and protein PEGylation

2002 • 1,564 citations

Clinical translation of angiogenesis inhibitors

2002 • 1,518 citations

Dendrimers and Other Dendritic Polymers

2001 • 1,409 citations

Structure and properties of pharmacologically active polymers

1975 • 1,069 citations

Gene Therapy Progress and Prospects: Nonviral vectors

2002 • 954 citations

Dendrimers and other dendritic polymers

2001 • 883 citations

Block copolymer micelles as vehicles for drug delivery

1993 • 866 citations

Effective drug delivery by PEGylated drug conjugates

2003 • 846 citations

The emerging field of nanotube biotechnology

2002 • 782 citations

Delivery of molecular and cellular medicine to solid tumors

2012 • 766 citations

Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee.

1999 • 689 citations

Different behavior of branched and linear polyethylenimine for gene deliveryin vitro andin vivo

2001 • 677 citations

Development of the polymer micelle carrier system for doxorubicin

2001 • 564 citations

HPMA copolymer–anticancer drug conjugates: design, activity, and mechanism of action

2000 • 554 citations

Therapeutic antibodies for human diseases at the dawn of the twenty-first century

2002 • 540 citations

Biological applications of dendrimers

2002 • 511 citations

Delivery of molecular and cellular medicine to solid tumors1PII of original article: S0169-409X(97)00027-6. The article was originally published in Advanced Drug Delivery Reviews 26 (1997) 71–90.1

2001 • 509 citations

Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini

2001 • 481 citations

Drug-polymer conjugates

1992 • 441 citations

Effect of molecular weight (M_w) ofN‐(2‐hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats

1987 • 428 citations

The uses and properties of PEG-linked proteins.

1992 • 425 citations

The next frontier of molecular medicine: Delivery of therapeutics

1998 • 408 citations

Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications

2002 • 408 citations

Hepatic Drug Targeting: Phase I Evaluation of Polymer-Bound Doxorubicin

2002 • 363 citations

Polyethylenimine/DNA complexes shielded by transferrin target gene expression to tumors after systemic application

2001 • 350 citations

Therapeutic antibody fragments with prolonged in vivo half-lives

1999 • 343 citations

Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate.

1998 • 339 citations

Polyacrylamides Bearing Pendant α-Sialoside Groups Strongly Inhibit Agglutination of Erythrocytes by Influenza Virus: The Strong Inhibition Reflects Enhanced Binding through Cooperative Polyvalent Interactions

1996 • 335 citations

Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier

1995 • 329 citations

New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties

2001 • 324 citations

Designing Macromolecules for Therapeutic Applications: Polyester DendrimerPoly(ethylene oxide) “Bow-Tie” Hybrids with Tunable Molecular Weight and Architecture

2002 • 317 citations

Preclinical safety evaluation of biotechnology-derived pharmaceuticals

2002 • 316 citations

Polymeric Antitumor Agents on a Molecular and on a Cellular Level?

1981 • 315 citations

Soluble synthetic polymers as potential drug carriers

1984 • 308 citations

RenaGel®, a nonabsorbed calcium- and aluminum-free phosphate binder, lowers serum phosphorus and parathyroid hormone

1999 • 300 citations

Hyperbranched Molecular Nanocapsules: Comparison of the Hyperbranched Architecture with the Perfect Linear Analogue

2002 • 300 citations

Mono-N-terminal poly(ethylene glycol)–protein conjugates

2002 • 299 citations

Safer and Virus-Free?

2001 • 297 citations

Poly[N-(2-hydroxypropyl)methacrylamide]—I. Radical polymerization and copolymerization

1973 • 294 citations

Polymer micelles as novel drug carrier: Adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer

1990 • 288 citations

Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image.

1984 • 283 citations

Star and Hyperbranched Polymers

1999 • 281 citations

The therapeutic value of poly(ethylene glycol)-modified proteins

1991 • 280 citations

Dendrimers and Hyperbranched Polymers: Two Families of Three-Dimensional Macromolecules with Similar but Clearly Distinct Properties

1996 • 279 citations

Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel

2001 • 273 citations

Delivery of molecular and cellular medicine to solid tumors

1997 • 268 citations

Hepatic Drug Targeting: Phase I Evaluation of Polymer-Bound Doxorubicin

2002 • 264 citations

Block copolymer-based formulation of doxorubicin. From cell screen to clinical trials

1999 • 263 citations

The origin of pegnology

2002 • 255 citations

Overcoming the Nuclear Barrier: Cell Cycle Independent Nonviral Gene Transfer with Linear Polyethylenimine or Electroporation

2002 • 245 citations

Polyethylene glycol-conjugated pharmaceutical proteins

1998 • 240 citations

Use of peginterferon alfa-2a (40 KD) (Pegasys®) for the treatment of hepatitis C

2002 • 235 citations

Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral delivery system?

2000 • 230 citations

Introduction and overview of peptide and protein pegylation

2002 • 229 citations

Gene transfer with lipospermines and polyethylenimines

1998 • 225 citations

Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity

1996 • 222 citations

The clinical efficacy of poly(ethylene glycol)-modified proteins

1990 • 219 citations

Adenosine deaminase deficiency with late onset of recurrent infections: Response to treatment with polyethylene glycol-modified adenosine deaminase

1988 • 217 citations

Poly(amido-amine)s: Biomedical Applications

2002 • 212 citations

Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger.

1998 • 211 citations

Stabilization of Substances in Circulation

1998 • 203 citations

Self-assembling complexes for gene delivery : from laboratory to clinical trial

1998 • 199 citations

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycinImmunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro

1989 • 196 citations

Polymer–drug conjugates, PDEPT and PELT: basic principles for design and transfer from the laboratory to clinic

2001 • 194 citations

Polymers containing enzymatically degradable bonds, 7. Design of oligopeptide side‐chains in poly[N‐(2‐hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal enzymes

1983 • 192 citations

Preclinical evaluation of polymer-bound doxorubicin

1992 • 189 citations

Enzymatic procedure for site-specific pegylation of proteins

2002 • 186 citations

HPMA copolymer platinates as novel antitumour agents: in vitro properties, pharmacokinetics and antitumour activity in vivo

1999 • 186 citations

Preliminary clinical study of the distribution of HPMA copolymers bearing doxorubicin and galactosamine

1999 • 177 citations

Polymer Conjugates

1994 • 167 citations

Tumour tropism and anti-cancer efficacy of polymer-based doxorubicin prodrugs in the treatment of subcutaneous murine B16F10 melanoma

1994 • 165 citations

Fundamentals Of Polymer Science

1998 • 161 citations

Biocompatibility of biomaterials: hemocompatibility, immunocompatiblity and biocompatibility of solid polymeric materials and soluble targetable polymeric carriers

1996 • 160 citations

Site-Directed Pegylation of Recombinant Interleukin-2 at its Glycosylation Site

1990 • 155 citations

Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments.

2002 • 147 citations

An ein kolloidales Blutplasma-Ersatzmittel (Polyvinylpyrrolidon) gebundenes Peptamin (Glycyl-L-leucyl-mezcalin) als neuartige Depotform für biologisch aktive primäre Amine (Mezcalin)

1955 • 145 citations

Tat-Conjugated Synthetic Macromolecules Facilitate Cytoplasmic Drug Delivery To Human Ovarian Carcinoma Cells

2002 • 145 citations

Fundamentals of Polymer Science

2019 • 142 citations

PVP

2018 • 141 citations

Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers

1985 • 138 citations

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats

1986 • 133 citations

Biologically Active Synthetic Polymers

1976 • 132 citations

PDEPT: polymer-directed enzyme prodrug therapy

2001 • 129 citations

Phase II Study of CT-2103 in Patients With Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma

2004 • 119 citations

A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin

2002 • 118 citations

Pegylated Interferon Alfa-2b Treatment for Patients With Solid Tumors: A Phase I/II Study

2002 • 117 citations

Pendent Chain Functionalized Polyacetals That Display pH-Dependent Degradation: A Platform for the Development of Novel Polymer Therapeutics

2001 • 114 citations

Fulfilling the promise: drug discovery in the post-genomic era

2003 • 106 citations

Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics

2000 • 105 citations

New types of synthetic infusion solutions. III. Elimination and retention of poly‐[N‐(2‐hydroxypropyl)methacrylamide] in a test organism

1976 • 104 citations

Polysialic acids: potential in drug delivery

1993 • 102 citations

Recent developments in the rational design of multivalent glycoconjugates

1997 • 101 citations

Tumor irradiation enhances the tumor-specific distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efficacy.

2000 • 99 citations

Poly(ethylene glycol) Multiblock Copolymer as a Carrier of Anti-Cancer Drug Doxorubicin

2000 • 95 citations

PDEPT: Polymer-Directed Enzyme Prodrug Therapy. 2. HPMA Copolymer-β-lactamase and HPMA Copolymer-C-Dox as a Model Combination

2003 • 95 citations

Drug-targeting strategies in cancer therapy

2001 • 88 citations

Micro‐MR angiography of normal and intratumoral vessels in mice using dedicated intravascular MR contrast agents with high generation of polyamidoamine dendrimer core: Reference to pharmacokinetic properties of dendrimer‐based MR contrast agents

2001 • 87 citations

Population pharmacokinetics in phase I drug development: a phase I study of PK1 in patients with solid tumours

1999 • 84 citations

Synthetic biologically active polymers

1975 • 81 citations

Antitumor effect of in vivo somatostatin receptor subtype 2 gene transfer in primary and metastatic pancreatic cancer models.

2002 • 81 citations

Polyethylene Glycol Modification: Relevance of Improved Methodology to Tumour Targeting

1996 • 81 citations

Reduced cardiotoxicity of doxorubicin given in the form ofN-(2-hydroxypropyl) methacrylamide conjugates: an experimental study in the rat

1991 • 77 citations

Copolymer 1: from basic research to clinical application

1997 • 73 citations

A Chemical Adaptor System Designed To Link a Tumor‐Targeting Device with a Prodrug and an Enzymatic Trigger

2003 • 69 citations

Preclinical toxicology of a novel polymeric antitumour agent: HPMA copolymerdoxorubicin (PK1)

1998 • 67 citations

HPMA Copolymers Platinates Containing Dicarboxylato Ligands. Preparation, Characterisation and In Vitro and In Vivo Evaluation

2002 • 64 citations

Drug Delivery Systems Employing 1,6-Elimination: Releasable Poly(ethylene glycol) Conjugates of Proteins

2001 • 63 citations

Immunogenicity of N-(2-hydroxypropyl) methacrylamide copolymers

1985 • 61 citations

Induction of Potent Human Immunodeficiency Virus Type 1-Specific T-Cell-Restricted Immunity by Genetically Modified Dendritic Cells

2001 • 56 citations

Review : Synthetic Polymers with Intrinsic Anticancer Activity

1991 • 53 citations

Neocarzinostatin: The past, present, and future of an anticancer drug

2000 • 53 citations

Adverse effects of gene therapy: Gene therapy can cause leukaemia: no shock, mild horror but a probe

2003 • 52 citations

Handbook of Anticancer Drug Development

2004 • 49 citations

A Placebo-controlled, Double-blind Prospective Study in Healthy Female Volunteers of Dextrin Sulphate Gel:

1997 • 48 citations

The Sequestration of Bile Acids, A Non-Absorbed Method for Cholesterol Reduction. A Review

1997 • 47 citations

Immunological problems of polymer-bound drugs.

1985 • 43 citations

Polycationic Graft Copolymers as Carriers for Oligonucleotide Delivery. Complexes of Oligonucleotides with Polycationic Graft Copolymers

2001 • 41 citations

Synthesis and Antigenic Properties of Sialic Acid Based Dendrimers

1994 • 39 citations

A novel modification of poly(L-lysine) leading to a soluble cationic polymer with reduced toxicity and with potential as a transfection agent

1998 • 38 citations

The further evolution of biotech

2002 • 38 citations

Icodextrin in Peritoneal Dialysis: Early Development and Clinical Use

1994 • 35 citations

Selective anticancer drugs

2002 • 35 citations

Reduction of the viral load of HIV-1 after the intraperitoneal administration of dextrin 2-sulphate in patients with AIDS

1998 • 33 citations

Metamorphosis of Neocarzinostatin to SMANCS: Chemistry, Biology, Pharmacology, and Clinical Effect of the First Prototype Anticancer Polymer Therapeutic

1997 • 32 citations

Anti-HIV Type 1 Activity of Sulfated Derivatives of Dextrin against Primary Viral Isolates of HIV Type 1 in Lymphocytes and Monocyte-Derived Macrophages

1997 • 32 citations

Synthesis, isolation and characterization ofPlasmodium falciparumantigenic tetrabranched peptide dendrimers obtained by thiazolidine linkages

2001 • 28 citations

Review: Advances in Intraperitoneal (Intracavitary) Administration of Synthetic Polymers for Immunotherapy and Chemotherapy

1986 • 26 citations

Antibody-targeted polymer-bound drugs

1995 • 24 citations

Targeting Chemotherapy of Hepatocellular Carcinoma

1987 • 22 citations

Clinical Science Review: The Routinization of Intraperitoneal (Intracavitary) Chemotherapy and Immunotherapy

1986 • 20 citations

Pharmacological study of CT-2103 (XyotaxTM), a poly(L-glutamic acid)-paclitaxel conjugate administered every 3 weeks or every 2 weeks in a phase I study

2002 • 18 citations

Biocompatibility of Biopolymers

1992 • 13 citations

Anti-Kaposi’s Sarcoma and Antiangiogenic Activities of Sulfated Dextrins

1999 • 7 citations

275 Phase 2 study of CT-2103 in patients with colorectal cancer having recurrent disease after treatment with a 4-fluorouracil-containing regimen

2003 • 5 citations

HOW TO OPTIMISE PEGVISOMANT TREATMENT OF ACROMEGALY SAFELY

2002 • 2 citations

Deleted Work

1955 • 0 citations