The therapeutic value of poly(ethylene glycol)-modified proteins

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

1977 • 1,311 citations

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

1977 • 1,239 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase.

1984 • 478 citations

Superoxide dismutase and pulmonary oxygen toxicity

1974 • 462 citations

Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

1987 • 450 citations

Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance.

1988 • 425 citations

LABORATORY SYNTHESIS OF POLYETHYLENE GLYCOL DERIVATIVES

1985 • 256 citations

Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model.

1987 • 248 citations

Application of polyethylene glycol-modified enzymes in biotechnological processes: organic solvent-soluble enzymes

1986 • 241 citations

Peptide and protein drug delivery

1992 • 222 citations

The clinical efficacy of poly(ethylene glycol)-modified proteins

1990 • 219 citations

Adenosine deaminase deficiency with late onset of recurrent infections: Response to treatment with polyethylene glycol-modified adenosine deaminase

1988 • 217 citations

Oxygen radicals mediate the cerebral arteriolar dilation from arachidonate and bradykinin in cats.

1984 • 215 citations

Polyethylene Glycol Reactive Antibodies in Man: Titer Distribution in Allergic Patients Treated with Monomethoxy Polyethylene Glycol Modified Allergens or Placebo, and in Healthy Blood Donors

1984 • 208 citations

A new procedure for the synthesis of polyethylene glycol-protein adducts; Effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and α2-macroglobulin

1983 • 205 citations

Oxygen Radical Dependent Lung Damage following Thermal Injury of Rat Skin

1983 • 182 citations

Inhibition of Lung Injury, Inflammation, and Interstitial Pulmonary Fibrosis by Polyethylene Glycol-conjugated Catalase in a Rapid Inhalation Model of Asbestosis

1990 • 165 citations

Biochemical and pharmacological studies with asparaginase in man.

1970 • 156 citations

Hypersensitive reactions and antibody formation during L-asparaginase treatment of children and adults with acute leukemia

1976 • 144 citations

The Toxicology of the Polyethylene Glycols*

1950 • 139 citations

Superoxide dismutase conjugated to polyethylene glycol provides sustained protection against myocardial ischemia/reperfusion injury in canine heart.

1988 • 126 citations

Effects of Free Radical Scavengers on Renal Circulation after Ischaemia in the Rabbit

1983 • 126 citations

Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol.

1981 • 124 citations

Immunotherapy with monomethoxypolyethylene glycol modified allergens.

1990 • 116 citations

'MIADONE'

1947 • 114 citations

Modification of E. coli L-asparaginase with polyethylene glycol: Disappearance of binding ability to anti-asparaginase serum

1978 • 113 citations

Evidence for a role of oxygen derived free radicals in the pathogenesis of caerulein induced acute pancreatitis in rats.

1988 • 112 citations

The absorption and excretion of the solid polyethylene glycols (“Carbowax” compounds)*1Mellon Institute of Industrial Research, Pittsburgh, Pa.

1947 • 111 citations

Polyethylene glycol-attached antioxidant enzymes decrease pulmonary oxygen toxicity in rats

1989 • 103 citations

Effects of superoxide radicals on myoblast growth and differentiation

1974 • 102 citations

Free radicals and disease in man.

1984 • 97 citations

L-Asparaginase

1970 • 96 citations

Reduction in immunogenicity and clearance rate of Escherichia coli L-asparaginase by modification with monomethoxypolyethylene glycol.

1981 • 93 citations

Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol

1979 • 90 citations

Orgotein: a new anti-inflammatory metalloprotein drug: preliminary evaluation of clinical efficacy and safety in degenerative joint disease.

1974 • 89 citations

Adenosine deaminase deficiency: Frequency and comparative pathology in autosomally recessive severe combined immunodeficiency

1979 • 87 citations

Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity.

1980 • 85 citations

Chemical reactions by polyethylene glycol-modified enzymes in chlorinated hydrocarbons

1985 • 84 citations

Some properties of polyethylene glycol:phenylalanine ammonia-lyase adducts.

1979 • 81 citations

Synthesis and application of a poly(ethylene glycol)-antibody affinity ligand for cell separations in aqueous polymer two-phase systems

1986 • 81 citations

Preparation and evaluation of pyridoxalated-polymerized human hemoglobin

1983 • 79 citations

Modification of human hemoglobin with polyethylene glycol: A new candidate for blood substitute

1980 • 75 citations

[New drugs. 8].

1972 • 73 citations

Preparation and properties of polyethylene glycol-trypsin adducts

1979 • 72 citations

Anti-inflammatory and pharmacokinetic properties of superoxide dismutase derivatized with polyethylene glycol via active esters

1983 • 67 citations

Preparation and Evaluation of Hemoglobin‐Polyethylene Glycol Conjugate (Pyridoxalated Polyethylene Glycol Hemoglobin) as an Oxygen‐Carrying Resuscitation Fluid

1986 • 65 citations

Properties of two urate oxidases modified by the covalent attachment of poly(ethylene glycol)

1981 • 65 citations

Physicochemical and biological properties of poly(ethylene glycol)-coupled immunoglobuling G

1984 • 62 citations

Suppression of Reaginic Antibodies with Modified Allergens

1978 • 61 citations

Comparison of anaphylactic reactions to asparaginase derived fromEscherichia coli and fromErwinia culturs

1976 • 60 citations

Anaphylaxis to L-Asparaginase during Treatment for Acute Lymphoblastic Leukemia in Children—Evidence of a Complement-Mediated Mechanism

1985 • 56 citations

Antioxidants and antioxidant enzymes protect against pulmonary oxygen toxicity in the rabbit

1990 • 55 citations

Use of Polyethylene Glycol-Modified Uricase (PEG-Uricase) to Treat Hyperuricemia in a Patient with Non-Hodgkin Lymphoma

1988 • 53 citations

Preparation of polyethylene glycol‐bound NAD and its application in a model enzyme reactor

1980 • 53 citations

Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species

1988 • 52 citations

The toxicity of high molecular weight polyethylene glycols; chronic oral and parenteral administration

1947 • 50 citations

Poly(ethylene glycol)s containing enzymatically degradable bonds

1986 • 50 citations

Hemoglobin solution--from tetramer to polymer.

1984 • 49 citations

Modification of batroxobin with activated polyethylene glycol: Reduction of binding ability towards anti-batroxobin antibody and retention of defibrinogenation activity in circulation of preimmunized dogs

1983 • 45 citations

A New Resuscitation Fluid “Stabiilized Hemoglobin” Preparation and Characteristics

1988 • 45 citations

HYPOURICAEMIC EFFECT OF POLYETHYLENEGLYCOL MODIFIED URATE OXIDASE

1981 • 44 citations

Orgotein: a new drug for the treatment of radiation cystitis.

1975 • 44 citations

Evidence against the "early protection-delayed death" hypothesis of superoxide dismutase therapy in experimental myocardial infarction. Polyethylene glycol-superoxide dismutase plus catalase does not limit myocardial infarct size in dogs.

1990 • 44 citations

Studies on antigenicity of the polyethylene glycol (PEG)-modified uricase

1985 • 44 citations

Development of a Perfluorochemical Emulsion as a Blood Gas Carrier

1984 • 43 citations

Circular dichroism and fluorescence of polyethylene glycol‐subtilisin in organic solvents

1988 • 41 citations

Effects of Coupling Chemistry on the Activity of Poly(ethylene glycol)-Modified Alkaline Phosphatase

1989 • 40 citations

A preliminary study on the evaluation of asparaginase. Polyethylene glycol conjugate against canine malignant lymphoma

1987 • 39 citations

Improved Modification of Yeast Uricase with Polyethylene Glycol, Accompanied with Nonimmunoreactivity towards Anti- Uricase Serum and High Enzymic Activity

1981 • 36 citations

A phase II trial of peg-L-asparaginase in the treatment of non-hodgkins lymphoma

1990 • 35 citations

Clinical pharmacologic studies of L‐asparaginase

1970 • 34 citations

Immunogenicity of polyethylene glycol-modified superoxide dismutase and catalase

1986 • 33 citations

In Vivo Evaluation of a<u>Pyridoxalated-Hemoglobin-Polyoxyethylene Conjugate</u>

1988 • 32 citations

Acylation of human hemoglobin with polyoxyethylene derivatives

1984 • 32 citations

Orgotein

1980 • 31 citations

Increased survival of skin flaps by scavengers of superoxide radical

1987 • 30 citations

Immune Responses to Polyethylene Glycol Modified &lt;i&gt;L&lt;/i&gt;&lt;i&gt;-&lt;/i&gt;Asparaginase in Mice

1985 • 29 citations

Succinimidyl Carbonates of Polyethylene Glycol

1991 • 29 citations

Approaches to prevention of asbestos-induced lung disease using polyethylene glycol (PEG)-conjugated catalase

1986 • 28 citations

A Study of the Polyethylene Glycols as Vehicles for Intramuscular and Subcutaneous Injection

1952 • 28 citations

Polyethylene glycol-modified ragweed pollen extract in rhinoconjunctivitis

1985 • 28 citations

Hemoglobin Solutions Coupled with Polyethylene Glycol 1900: Preparation, Purification, Quality Control and Pharmacological Trials by Hemorrhagic Shock

1988 • 25 citations

The effects of immunization to L-asparaginase on antitumor and enzymatic activity.

1973 • 24 citations

Modification of amino groups in porcine pancreatic elastase with polyethylene glycol in relation to binding ability towards anti-serum and to enzymic activity

1983 • 24 citations

Clinical Pharmacology of Intramuscularly Administeredl-Asparaginase

1981 • 23 citations

The effects of oxygen free radicals on the preserved kidney

1987 • 23 citations

Synthesis of monomethoxypolyoxyethylene-bound haemoglobins

1984 • 22 citations

Catalytic Activity of Administered Gulonolactone Oxidase Polyethylene Glycol Conjugates

1989 • 22 citations

Hemoglobin-inulin conjugate as an oxygen carrying blood substitute

1983 • 22 citations

Morphologic effects following massive exchange transfusions with a stroma-free hemoglobin solution. I. Liver.

1978 • 21 citations

Safety and Plasma Concentrations of Bovine Superoxide Dismutase Administered to Human Premature Infants

1982 • 21 citations

Immunologic responses to conjugates of antigen E in patients with ragweed hay fever

1984 • 20 citations

Physiologic Effects of Pyridoxalated-Hemoglobin-Polyethylene Glycol Conjugate Solution in Exchange Transfusion

1986 • 20 citations

Mitigation of Pulmonary Oxygen Toxicity in Premature Lambs with Intravenous Antioxidants

1990 • 16 citations

Immunosuppressive properties and circulating life of Achromobacter glutaminase-asparaginase covalently attached to polyethylene glycol in man.

1981 • 15 citations

Modification of acyl‐plasmin‐streptokinase complex with polyethylene glycol

1985 • 13 citations

Structure activity relations in homologous alkyl polyglycol ethers

1973 • 12 citations

Failure of antioxidant therapy (polyethylene glycol-conjugated catalase) in acute pancreatitis

1989 • 12 citations

Haemoglobin pyridoxylation: optimization and observation of an additional new pyridoxal phosphate—haemoglobin species by high-performance liquid chromatographic resolution

1987 • 11 citations

Bovine superoxide dismutase in Fanconi anaemia. Therapeutic trial in two patients

1985 • 10 citations

Properties of a Novel PEG Derivative of Calf Adenosine Deaminase

1984 • 8 citations

A blood substitute from hydroxyethyl starch and hemoglobin

1984 • 8 citations

A Blood Substitute from Hydroxyethyl Starch and Hemoglobin

1984 • 6 citations

Studies of Chemically Modified Honeybee Venom II.

1982 • 4 citations

276 Antigen-specific humoral and cellular immune responses during treatment of adenosine deaminase deficient severe combined immunodeficiency (ADA-SCID) with polyethylene glycol-modified bovine adenosine deaminase (PEG-ADA)

1988 • 2 citations

277 The use of bovine polyethylene glycol-modified adenosine deaminase (PEG-ADA) in correcting the immunodeficiency in a child with severe combined immunodeficiency-adenosine deaminase deficiency (SCID-ADA[ − ])

1988 • 1 citations

275 Immunogenecity of polyethylene glycol-modified bovine adenosine deaminase (PEG-ADA)

1988 • 1 citations