Stability in rat plasma and serum of lysosomally degradable oligopeptide sequences in N-(2-hydroxypropyl) methacrylamide copolymers

Soluble synthetic polymers as potential drug carriers

1984 • 308 citations

Polymers containing enzymatically degradable bonds, 8. Degradation of oligopeptide sequences in N‐(2‐hydroxypropyl)methacrylamide copolymers by bovine spleen cathepsin B

1983 • 259 citations

A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in vivo studies.

1982 • 232 citations

Polymers containing enzymatically degradable bonds, 7. Design of oligopeptide side‐chains in poly[N‐(2‐hydroxypropyl)methacrylamide] copolymers to promote efficient degradation by lysosomal enzymes

1983 • 192 citations

Controlled biodegradability of polymers — a key to drug delivery systems

1984 • 155 citations

Polymers containing enzymatically degradable bonds, 1. Chymotrypsin catalyzed hydrolysis of p‐nitroanilides of phenylalanine and tyrosine attached to side‐chains of copolymers of N‐(2‐hydroxypropyl)methacrylamide

1981 • 141 citations

Enzymatic cleavage of side chains of synthetic water‐soluble polymers

1976 • 118 citations

Degradation of side-chains of N-(2-hydroxypropyl)methacrylamide copolymers by lysosomal thiol-proteinases

1982 • 102 citations

Degradation of side chains of N-(2 hydroxypropyl) methacrylamide copolymers by lysosomal enzymes

1980 • 68 citations

Polymers containing enzymatically degradable bonds V. Hydrophilic polymers degradable by papain

1980 • 65 citations

Polymers containing enzymatically degradable bonds, 3. Poly[N‐(2‐hydroxypropyl)methacrylamide] chains connected by oligopeptide sequences cleavable by trypsin

1981 • 58 citations

Polymers containing enzymatically degradable bonds, 2. Poly[N‐(2‐hydroxypropyl)methacrylamide] chains connected by oligopeptide sequences cleavable by chymotrypsin

1981 • 57 citations

Recent advances in drug delivery systems

1985 • 55 citations

Polymers containing enzymatically degradable bonds, 4. Preliminary experiments in vivo

1981 • 55 citations

Low molecular weight inhibitors of cathepsins B, H and T in human serum, synovial fluid and CSF

1982 • 35 citations

Synthesis of Tailor-Made Soluble Polymeric Drug Carriers

1984 • 31 citations

Development of N-(2-Hydroxypropyl)Methacrylamide Copolymers as Carriers of Therapeutic Agents

1983 • 24 citations

Existence of two kinds of thiol protease inhibitors in rat serum

1982 • 19 citations

Plasma acid hydrolases in normal adults and children, and in patients with some lysosomal storage diseases

1978 • 18 citations

Mechanism of reaction of human plasmin with

1974 • 15 citations

An evaluation of the utility of benzoyl-DL-arginine-β-naphthylamide for the assay of thrombin activity in blood

1974 • 2 citations