Clinical Science Review: The Routinization of Intraperitoneal (Intracavitary) Chemotherapy and Immunotherapy

The blood supply of neoplasms in the liver.

1954 • 1,280 citations

Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

1978 • 707 citations

Intraperitoneal Cisplatin with Systemic Thiosulfate Protection

1982 • 494 citations

The route of absorption of intraperitoneally administered compounds.

1971 • 352 citations

Soluble synthetic polymers as potential drug carriers

1984 • 308 citations

Phase I and pharmacological studies of 5-fluorouracil administered intraperitoneally.

1980 • 249 citations

Immune Modulation Agents and their Mechanisms

1985 • 246 citations

Phase I and pharmacological studies of adriamycin administered intraperitoneally to patients with ovarian cancer.

1982 • 218 citations

Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans.

1981 • 211 citations

Cellular and Molecular Mechanisms of Action of Bacterial Endotoxins

1979 • 198 citations

Nonlinear pharmacokinetic models for 5-fluorouracil in man: Intravenous and intraperitoneal routes

1980 • 181 citations

Site–Specific (Targeted) Drug Delivery in Cancer Therapy

1983 • 166 citations

Immune modulation and control of neoplasia by adjuvant therapy

1978 • 152 citations

Macrophage-mediated destruction of malignant tumor cells and new strategies for the therapy of metastatic disease

1982 • 145 citations

Improved regional selectivity of hepatic arterial bcnu with degradable microspheres

1982 • 144 citations

Intraperitoneal contrast infusion for assessment of intraperitoneal fluid dynamics

1979 • 117 citations

Microvascular transport of macromolecules in normal and inflammatory conditions.

1979 • 109 citations

High volume intraperitoneal chemotherapy (?Belly bath?) for ovarian cancer

1978 • 107 citations

Surgical considerations in the management of hepatic neoplasia.

1983 • 100 citations

High-volume intraperitoneal chemotherapy with methotrexate in patients with cancer.

1981 • 100 citations

Transport of Model Compounds across the Peritoneal Membrane in the Rat

1978 • 97 citations

Immunopharmacology of glucan: a broad spectrum enhancer of host defense mechanisms

1983 • 95 citations

Combination intraperitoneal chemotherapy with cisplatin, cytarabine, and doxorubicin for refractory ovarian carcinoma and other malignancies principally confined to the peritoneal cavity.

1984 • 94 citations

Novel Approaches to Cancer Chemotherapy

1984 • 93 citations

A Totally Implanted Injection Port System for Blood Sampling and Chemotherapy Administration

1984 • 89 citations

Inhibition of human ovarian cancer colony formation by adriamycin and its major metabolites.

1980 • 88 citations

Controlled Blocking of Hepatic Artery Flow with Enzymatically Degradable Microspheres Combined with Oncolytic Drugs

1979 • 86 citations

Pharmacology of Intraperitoneal Chemotherapy

1983 • 81 citations

Immunotherapy with autologous white cell infusions (“lymphocytes”) in the treatment of recurrent glioblastoma multiforme.A preliminary report

1977 • 79 citations

Long-duration intracavitary infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions.

1981 • 76 citations

Intraperitoneal cytosine arabinoside therapy in ovarian carcinoma.

1984 • 70 citations

Intraperitoneal immunotherapy of human ovarian carcinoma with Corynebacterium parvum.

1983 • 69 citations

Technical considerations in the use of intraperitoneal chemotherapy administered by Tenckhoff catheter.

1982 • 69 citations

Kinetics of sodium thiosulfate, a cisplatin neutralizer

1984 • 63 citations

The use of intraperitoneal chemotherapy in the treatment of ovarian cancer.

1984 • 59 citations

INTRACAVITARY ADRIAMYCIN NITROGEN MUSTARD AND TETRACYCLINE IN THE CONTROL OF MALIGNANT EFFUSIONS: A RANDOMIZED STUDY

1980 • 58 citations

Intraperitoneal hyperthermic treatment of implanted peritoneal cancer in rats.

1980 • 57 citations

Adjuvant liver perfusion in colorectal cancer: initial results of a clinical trial.

1977 • 55 citations

Experimental antitumor activity and preclinical toxicology of mycophenolic acid.

1972 • 54 citations

Intraperitoneal spread of malignancies and its effect on the bowel

1981 • 49 citations

The Use of Peritoneal Dialysis for Delivery of Chemotherapy to Intraperitoneal Malignancies

1980 • 46 citations

Peritoneal electrolyte absorption: analysis of portal, systemic venous, and lymphatic transport.

1968 • 45 citations

Interaction of mesothelium to intraperitoneal stimulation. I. Aggregation of peritoneal cells.

1983 • 44 citations

Constant intraperitoneal 5-fluorouracil infusion through a totally implanted system

1984 • 42 citations

The biological activity of the synthetic polyanion, pyran copolymer (diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: Clinical and laboratory effect of these agents as modulators of host resistance

1981 • 38 citations

Liposomes as a Drug Delivery System in Cancer Therapy

1984 • 37 citations

Chemotherapy for murine ovarian cancer: a rationale for ip therapy with adriamycin.

1979 • 35 citations

Immunomodulatory effect of various molecular-weight maleic anhydride-divinyl ethers and other agents in vivo.

1980 • 35 citations

Immunotoxins

1984 • 30 citations

Drug Targeting in Cancer Therapy

1984 • 29 citations

Intraperitoneal infusion of doxorubicin in the treatment of gynecologic carcinomas

1981 • 29 citations

The metabolism of cis-dichlorodiammineplatinum (II): Distribution, clearance, and toxicity

1981 • 27 citations

Effect of pyran copolymer on activation of murine macrophages: evidence for incomplete activation by use of functional markers.

1983 • 26 citations

Hydrogen ion dynamics and cancer: An appraisal

1982 • 25 citations

Morphological studies on V2 carcinoma invasion and tumor-associated connective tissue changes in the rabbit mesentery.

1983 • 25 citations

Translocation of particles from lung lobes or the peritoneal cavity to regional lymph nodes in beagle dogs

1983 • 25 citations

Enhancement, by Two Carboxylic Acid Interferon Inducers, of Resistance Stimulated in Mice by Foot-and-Mouth Disease Vaccine

1973 • 24 citations

Hepatic artery ligation and portal vein infusion for liver metastases from colon cancer.

1984 • 24 citations

A comparative study of histamine secretion from rat peritoneal and pleural mast cells

1982 • 22 citations

Contemporary Topics in Immunobiology

1972 • 21 citations

Fibronectin levels during intraperitoneal inflammation

1983 • 21 citations

Phase II trial of 5-FU administered Ip to patients with refractory ovarian cancer.

1984 • 19 citations

Platelet Blockade of Particle Absorption from the Peritoneal Surface of the Diaphragm

1981 • 17 citations

Drug targeting: Magnetically responsive albumin microspheres—A review of the system to date

1981 • 16 citations

EXPERIMENTAL PERITONITIS AND PERITONEAL IMMUNITY

1929 • 16 citations

Evaluation of the immunological and toxicological properties of MVE-2 in phase I trials.

1983 • 14 citations

Induction of delayed hypersensitivity reactions in cancer patients by cholesterol-hemisuccinate-treated autologous tumor cells.

1983 • 14 citations

Phase I study of MVE-2 therapy in human cancer.

1983 • 14 citations

The effect of intravenous aprotinin (Trasylol) on intraperitoneal adhesion formation in the rat

1981 • 13 citations

Clinical studies with mismatched double-stranded RNA.

1981 • 11 citations

Intraperitoneal Infusion of Non-Absorbable Steroids in the Treatment of Ascites and Sterile Peritonitis

1980 • 11 citations

Mechanisms of the adjuvant effect of hemoglobin in experimental peritonitis. IV. The adjuvant effect of hemoglobin in granulocytopenic rats.

1981 • 11 citations

Characteristics of uptake and cytotoxicity of a low-density lipoprotein-daunomycin complex in P388 leukemic cells.

1984 • 10 citations

Effect of Erythrocyte Debris on Reticuloendothelial Function and Susceptibility to Experimental Peritonitis

1981 • 10 citations

Chronic inflammatory reactions in the guinea-pig peritoneal cavity induced by continuous local PPD stimulation. Immune status dependency of the accumulation of lymphocytes and eosinophils.

1980 • 9 citations

The role of radioactive colloids in malignant peritoneal mesotheliomas

1983 • 9 citations

In vivo modulation of myelopoiesis and immune functions by maleic anhydride divinyl ether copolymer (MVE-2) in tumor-free and MBL-2 tumor-bearing mice treated with cyclophosphamide.

1985 • 8 citations

Immunological and Tumor Responses to Various Immunotherapeutic Agents

1981 • 8 citations

Current Status of Human Cancer Immunotherapy

1981 • 6 citations

Effect of peritonitis on oxygen consumption by various tissues and peritoneal fluid cells.

1980 • 5 citations

Accumulation of T cells and local antippd antibody production in lymphokine‐mediated chronic peritoneal inflammation in the guinea pig

1980 • 5 citations

Tissue distribution of adriamycin administered intraperitoneally vs. intravenously, with special emphasis on the pancreas.

1982 • 5 citations

A Phase I Trial of Intracavitary Doxorubicin (Adriamycin) Alternating with Cisplatin

1984 • 4 citations

Administration of BCG cell wall skeleton into malignant effusions: toxic and therapeutic effects.

1981 • 4 citations

Pharmacological Therapy

2013 • 4 citations

Complement Synthesis by Guinea Pig Peritoneal Macrophages: Failure To Detect Chemical Carcinogens<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>

1981 • 3 citations

Influence of septic peritonitis on circulating fibronectin, immunoglobulin, and complement: relationship to reticuloendothelial phagocytic function.

1983 • 3 citations

Determination of the biological response modifier MVE-2 (AD-022) in biological fluids by high-performance liquid chromatography

1983 • 3 citations

Vitamin b6 inhibits the growth of b16 melanoma cells in bd2f1 mice. Abstr.

1983 • 2 citations

Intracavity 5-fluorouracil for control of malignant effusions.

1968 • 2 citations

Phytohemagglutinin (PHA) stimulated lymphocytes as systemic therapy for advanced renal cancer

1982 • 1 citations

Response of advanced l1210 in mice to single doses of deoxyazacytidine in combination with thymidine or pyran copolymer (mve-4). Abstr.

1983 • 1 citations