Copolymer 1: from basic research to clinical application

Copolymer 1 reduces relapse rate and improves disability in relapsing‐remitting multiple sclerosis

1995 • 1,903 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

A Pilot Trial of Cop 1 in Exacerbating–Remitting Multiple Sclerosis

1987 • 465 citations

Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide

1971 • 431 citations

Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity.

1994 • 243 citations

A placebo‐controlled, double‐blind, randomized, two‐center, pilot trial of Cop 1 in chronic progressive multiple sclerosis

1991 • 176 citations

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

1994 • 121 citations

Effect of Cyclophosphamide on Suppressor Cell Activity in Mice Unresponsive to EAE

1979 • 117 citations

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1.

1988 • 115 citations

Synthetic copolymer 1 inhibits human T-cell lines specific for myelin basic protein.

1992 • 111 citations

In vivo and in vitro immunological cross‐reactions between basic encephalitogen and synthetic basic polypeptides capable of suppressing experimental allergic encephalomyelitis

1973 • 103 citations

T suppressor hybridomas and interleukin‐2‐dependent lines induced by copolymer 1 or by spinal cord homogenate down‐regulate experimental allergic encephalomyelitis

1993 • 88 citations

Cross-reactions and specificities of monoclonal antibodies against myelin basic protein and against the synthetic copolymer 1.

1991 • 82 citations

Molecular requirements involved in suppression of eae by synthetic basic copolymers of amino acids

1976 • 66 citations

The effect of Cop 1, a synthetic polypeptide, on chronic relapsing experimental allergic encephalomyelitis in guinea pigs

1979 • 59 citations

Suppressive activity of Cop 1 in EAE and its relevance to multiple sclerosis.

1990 • 14 citations

Copolymer 1 induces suppressor T cells of the Th2 type

1996 • 2 citations