Hepatic Drug Targeting: Phase I Evaluation of Polymer-Bound Doxorubicin

Structure and properties of pharmacologically active polymers

1975 • 1,069 citations

Cancer-related fatigue: Inevitable, unimportant and untreatable? Results of a multi-centre patient survey

2000 • 428 citations

Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.

1982 • 357 citations

Biocompatibility of N-(2-hydroxypropyl) methacrylamide copolymers containing adriamycinImmunogenicity, and effect on haematopoietic stem cells in bone marrow in vivo and mouse splenocytes and human peripheral blood lymphocytes in vitro

1989 • 196 citations

Preclinical evaluation of polymer-bound doxorubicin

1992 • 189 citations

Preliminary clinical study of the distribution of HPMA copolymers bearing doxorubicin and galactosamine

1999 • 177 citations

Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats

1986 • 133 citations

N-(2-Hydroxypropyl)methacrylamide copolymers targeted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice

1991 • 116 citations

Studies on the in vivo disposition of adriamycin in human tumours which exhibit different responses to the drug

1986 • 108 citations

Solution properties of drug carriers based on poly[N‐(2‐hydroxypropyl)methacrylamide] containing biodegradable bonds

1987 • 95 citations

Endocytosis via galactose receptors in vivo

1986 • 78 citations

Pharmacokinetics of receptor-mediated hepatic uptake of glycosylated albumin in mice

1992 • 72 citations

Distribution of asialoglycoprotein receptor in human hepatocellular carcinoma

1993 • 55 citations

Soluble polymers for lectin-mediated drug targeting

1994 • 51 citations

Polymeric conjugates of drugs and antibodies for site‐specific drug delivery

1996 • 48 citations

In vivo quantification of receptor-mediated uptake of asialoglycoproteins by rat liver.

1983 • 46 citations

Gamma Scintigraphy of a¹²³I-Labelled N-(2-Hydroxypropyl)Methacrylamide Copolymer-Doxorubicin Conjugate Containing Galactosamine Following Intravenous Administration to Nude Mice Bearing Hepatic Human Colon Carcinoma

1996 • 44 citations

Decreased hepatic function in patients with hepatoma or liver metastasis monitored by a hepatocyte specific galactosylated radioligand

1990 • 44 citations

Mesangial cells possess an asialoglycoprotein receptor with affinity for human immunoglobulin A.

1998 • 44 citations

Comparison of the liver subcellular distribution of free daunomycin and that bound to galactosamine targeted N-(2-hydroxypropyl)methacrylamide copolymers, following intravenous administration in the rat

1991 • 35 citations

Evaluation of protein-N-(2-hydroxypropyl) methacrylamide copolymer conjugates as targetable drug-carriers. 2. Body distribution of conjugates containing transferrin, antitransferrin receptor antibody or anti-Thy 1.2 antibody and effectiveness of transferrin-containing daunomycin conjugates against mouse L1210 leukaemia in vivo

1992 • 26 citations

Antibody-targeted polymer-bound drugs

1995 • 24 citations

Functional liver imaging with 99 Tcm-galactosyl-neoglycoalbumin (NGA) in alcoholic liver cirrhosis and liver fibrosis

1991 • 20 citations

Hepatic uptake of asialoglycoprotein is different among mammalian species due to different receptor distribution

1988 • 12 citations

METHODOLOGICAL ASPECTS OF PHASE-I STUDIES OF NOVEL ANTICANCER AGENTS (REVIEW)

1992 • 3 citations