Common molecular mechanisms in explicit and implicit memory

LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS

1957 • 7,145 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat

1971 • 5,884 citations

The Molecular Biology of Memory Storage: A Dialogue Between Genes and Synapses

2001 • 3,785 citations

LTP and LTD

2004 • 3,754 citations

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

2000 • 2,700 citations

AMPA Receptor Trafficking and Synaptic Plasticity

2002 • 2,540 citations

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

1998 • 2,538 citations

Transcriptional regulation by the phosphorylation-dependent factor CREB

2001 • 2,488 citations

Structural basis of long-term potentiation in single dendritic spines

2004 • 2,331 citations

Function and Regulation of CREB Family Transcription Factors in the Nervous System

2002 • 2,037 citations

The molecular basis of CaMKII function in synaptic and behavioural memory

2002 • 1,855 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Synaptic tagging and long-term potentiation

1997 • 1,689 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Effects of cAMP Simulate a Late Stage of LTP in Hippocampal CA1 Neurons

1993 • 1,212 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Regulation of Histone Acetylation during Memory Formation in the Hippocampus

2004 • 1,091 citations

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

2000 • 1,085 citations

Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses

2004 • 989 citations

Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues

2005 • 977 citations

Structural plasticity and memory

2004 • 971 citations

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

1994 • 959 citations

Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

2004 • 870 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Structural Changes Accompanying Memory Storage

1993 • 851 citations

CBP Histone Acetyltransferase Activity Is a Critical Component of Memory Consolidation

2004 • 814 citations

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

1986 • 767 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

Epigenetic mechanisms in memory formation

2005 • 739 citations

Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

1997 • 738 citations

Defining the CREB Regulon

2004 • 708 citations

Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

1996 • 701 citations

Protein Synthesis at Synaptic Sites on Dendrites

2001 • 682 citations

Development of Long-Term Dendritic Spine Stability in Diverse Regions of Cerebral Cortex

2005 • 672 citations

CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

1995 • 639 citations

dunce, a mutant of Drosophila deficient in learning.

1976 • 620 citations

CREB required for the stability of new and reactivated fear memories

2002 • 616 citations

Dynamic Visualization of Local Protein Synthesis in Hippocampal Neurons

2001 • 602 citations

Induction of CRE-Mediated Gene Expression by Stimuli That Generate Long-Lasting LTP in Area CA1 of the Hippocampus

1996 • 594 citations

Bidirectional Activity-Dependent Morphological Plasticity in Hippocampal Neurons

2004 • 587 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

1995 • 575 citations

Expression of Constitutively Active CREB Protein Facilitates the Late Phase of Long-Term Potentiation by Enhancing Synaptic Capture

2002 • 571 citations

In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain

1990 • 566 citations

A Neuronal Isoform of the Aplysia CPEB Has Prion-Like Properties

2003 • 561 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

1997 • 548 citations

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

1998 • 532 citations

Neuronal Correlates of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 529 citations

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

1994 • 528 citations

Synaptic Facilitation and Behavioral Sensitization in Aplysia : Possible Role of Serotonin and Cyclic AMP

1976 • 515 citations

A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis

1999 • 510 citations

Evidence for the involvement of TNF and NF-?B in hippocampal synaptic plasticity

2000 • 509 citations

Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

2002 • 494 citations

A Model of Synaptic Memory

2001 • 488 citations

Antisense oligodeoxynucleotide-mediated disruption of hippocampal cAMP response element binding protein levels impairs consolidation of memory for water maze training

1997 • 484 citations

Dendritic spines and long-term plasticity

2005 • 477 citations

Neuronal Mechanisms of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 477 citations

Reversible Inhibition of CREB/ATF Transcription Factors in Region CA1 of the Dorsal Hippocampus Disrupts Hippocampus-Dependent Spatial Memory

2002 • 468 citations

Protein phosphatase 1 is a molecular constraint on learning and memory

2002 • 465 citations

Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin

2001 • 464 citations

Polyribosomes Redistribute from Dendritic Shafts into Spines with Enlarged Synapses during LTP in Developing Rat Hippocampal Slices

2002 • 459 citations

Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster

1981 • 444 citations

Long-Term Memory Is Facilitated by cAMP Response Element-Binding Protein Overexpression in the Amygdala

2001 • 441 citations

A Neuronal Isoform of CPEB Regulates Local Protein Synthesis and Stabilizes Synapse-Specific Long-Term Facilitation in Aplysia

2003 • 426 citations

Morphological Basis of Long-Term Habituation and Sensitization in Aplysia

1983 • 420 citations

Activation of immediate early genes and memory formation

1999 • 413 citations

Nitric Oxide Signaling Contributes to Late-Phase LTP and CREB Phosphorylation in the Hippocampus

1999 • 404 citations

Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.

1994 • 394 citations

LTP mechanisms: from silence to four-lane traffic

2000 • 382 citations

Neurobiology: Memory and molecular turnover

1984 • 377 citations

Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia

1992 • 377 citations

Compartmentalized Synthesis and Degradation of Proteins in Neurons

2003 • 375 citations

Restricted and Regulated Overexpression Reveals Calcineurin as a Key Component in the Transition from Short-Term to Long-Term Memory

1998 • 365 citations

CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation

1998 • 363 citations

Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia

1997 • 359 citations

Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin

1998 • 355 citations

Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia.

1982 • 350 citations

Neuronal Activity Regulates Diffusion Across the Neck of Dendritic Spines

2005 • 344 citations

Some Forms of cAMP-Mediated Long-Lasting Potentiation Are Associated with Release of BDNF and Nuclear Translocation of Phospho-MAP Kinase

2001 • 333 citations

Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage

2005 • 327 citations

Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

1995 • 326 citations

Gene Expression Profiling of Facilitated L-LTP in VP16-CREB Mice Reveals that BDNF Is Critical for the Maintenance of LTP and Its Synaptic Capture

2005 • 323 citations

Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory

1998 • 320 citations

A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4

2003 • 317 citations

Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia

1992 • 313 citations

Tetanic Stimulation Leads to Increased Accumulation of Ca²⁺/Calmodulin-Dependent Protein Kinase II via Dendritic Protein Synthesis in Hippocampal Neurons

1999 • 296 citations

Time-restricted role for dendritic activation of the mTOR-p70 ^S6K pathway in the induction of late-phase long-term potentiation in the CA1

2003 • 295 citations

Long-term memory in Aplysia modulates the total number of varicosities of single identified sensory neurons.

1988 • 291 citations

The Persistence of Long-Term Memory

2004 • 274 citations

N-methyl-D-aspartate receptor signaling results in Aurora kinase-catalyzed CPEB phosphorylation and alphaCaMKII mRNA polyadenylation at synapses

2002 • 258 citations

Genome-Wide Analysis of CREB Target Genes Reveals A Core Promoter Requirement for cAMP Responsiveness

2003 • 253 citations

Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation

2004 • 236 citations

Does cAMP Response Element-Binding Protein Have a Pivotal Role in Hippocampal Synaptic Plasticity and Hippocampus-Dependent Memory?

2003 • 234 citations

Weak before strong: dissociating synaptic tagging and plasticity-factor accounts of late-LTP

1998 • 234 citations

Target-Dependent Structural Changes Accompanying Long-Term Synaptic Facilitation in Aplysia Neurons

1990 • 230 citations

Three Drosophila mutations that block associative learning also affect habituation and sensitization.

1982 • 224 citations

Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform.

1996 • 221 citations

Chromatin remodeling in neural development and plasticity

2005 • 220 citations

Dendritic Spine Geometry: Functional Implication and Regulation

2005 • 219 citations

Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB

2005 • 218 citations

SRF mediates activity-induced gene expression and synaptic plasticity but not neuronal viability

2005 • 217 citations

Deficits in Memory Tasks of Mice with CREB Mutations Depend on Gene Dosage

1998 • 214 citations

A novel intermediate stage in the transition between short- and long-term facilitation in the sensory to motor neuron synapse of aplysia

1995 • 209 citations

Acetylation of Nuclear Factor-κB in Rat Amygdala Improves Long-Term but not Short-Term Retention of Fear Memory

2004 • 199 citations

Two previously undescribed members of the mouse CPEB family of genes and their inducible expression in the principal cell layers of the hippocampus

2003 • 194 citations

Local translational control in dendrites and its role in long‐term synaptic plasticity

2005 • 189 citations

CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects

2003 • 188 citations

Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons

1997 • 185 citations

Flies, Genes, and Learning

2001 • 184 citations

Molecular Mechanisms Underlying a Unique Intermediate Phase of Memory in Aplysia

2001 • 183 citations

Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia

1992 • 181 citations

CREB Binds to Multiple Loci on Human Chromosome 22

2004 • 172 citations

A Late Phase of Cerebellar Long-Term Depression Requires Activation of CaMKIV and CREB

1999 • 170 citations

Synapse to Nucleus Signaling during Long-Term Synaptic Plasticity

2004 • 143 citations

Presynaptic Activation of Silent Synapses and Growth of New Synapses Contribute to Intermediate and Long-Term Facilitation in Aplysia

2003 • 139 citations

Inducible repression of CREB function disrupts amygdala-dependent memory

2004 • 137 citations

A semi-persistent adult ocular dominance plasticity in visual cortex is stabilized by activated CREB

2004 • 133 citations

A role for dendritic protein synthesis in hippocampal late LTP

2003 • 131 citations

THE INFLUENCE OF ACTINOMYCIN‐D ON BRAIN RNA SYNTHESIS AND ON MEMORY*

1964 • 131 citations

INHIBITION OF PROTEIN SYNTHESIS IN BRAIN AND LEARNING AND MEMORY FOLLOWING PUROMYCIN*

1962 • 130 citations

The Role of cAMP Response Element-Binding Protein inDrosophilaLong-Term Memory

2004 • 123 citations

Activation of a Tyrosine Kinase-MAPK Cascade Enhances the Induction of Long-Term Synaptic Facilitation and Long-Term Memory in Aplysia

2003 • 120 citations

Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7.

1988 • 120 citations

Long-Term Facilitation in Aplysia Involves Increase in Transmitter Release

1988 • 119 citations

Somatic action potentials are sufficient for late-phase LTP-related cell signaling

2002 • 117 citations

Behavioral analysis of CREB αΔ mutation on a B6/129 F1 hybrid background

2002 • 111 citations

Dynamics of Induction and Expression of Long-Term Synaptic Facilitation inAplysia

1996 • 109 citations

Synaptic plasticity in the basolateral amygdala in transgenic mice expressing dominant‐negative cAMP response element‐binding protein (CREB) in forebrain

2000 • 101 citations

Serotonin-Induced Regulation of the Actin Network for Learning-Related Synaptic Growth Requires Cdc42, N-WASP, and PAK in Aplysia Sensory Neurons

2005 • 100 citations

Upregulation of cAMP Response Element-Mediated Gene Expression during Experience-Dependent Plasticity in Adult Neocortex

2000 • 95 citations

Protein synthesis-dependent LTP in isolated dendrites of CA1 pyramidal cells

2005 • 94 citations

p38 MAP Kinase Mediates Both Short-Term and Long-Term Synaptic Depression inAplysia

2003 • 92 citations

Synaptic Facilitation and Behavioral Dishabituation in Aplysia: Dependence on Release of Ca2+ from Postsynaptic Intracellular Stores, Postsynaptic Exocytosis, and Modulation of Postsynaptic AMPA Receptor Efficacy

2005 • 91 citations

Memory and cerebral protein synthesis in mice as affected by graded amounts of puromycin

1965 • 88 citations

Presynaptic Morphological Changes Associated with Long-Term Synaptic Facilitation Are Triggered by Actin Polymerization at Preexisting Varicositis

2000 • 84 citations

Enhancement of Memory-Related Long-Term Facilitation by ApAF, a Novel Transcription Factor that Acts Downstream from Both CREB1 and CREB2

2000 • 75 citations

Capture of the Late Phase of Long-Term Potentiation within and across the Apical and Basilar Dendritic Compartments of CA1 Pyramidal Neurons: Synaptic Tagging Is Compartment Restricted

2006 • 75 citations

Cell and molecular analysis of long-term sensitization in Aplysia.

1986 • 70 citations

A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing

2004 • 70 citations

Inhibition of calcineurin facilitates the induction of memory for sensitization inAplysia: Requirement of mitogen-activated protein kinase

2003 • 58 citations

Structural plasticity at identified synapses during long‐term memory in Aplysia

1989 • 54 citations

Discussion

1998 • 47 citations

Role of Calcium-Calmodulin–Dependent Protein Kinase II in Modulation of Sensorimotor Synapses inAplysia

1997 • 28 citations

Role of Aplysia Cell Adhesion Molecules During 5-HT-Induced Long-Term Functional and Structural Changes

2004 • 27 citations

Synapse to Nucleus Signaling during Long-Term Synaptic Plasticitya Role for the Classical Active Nuclear Import Pathway

2004 • 20 citations