Regulation of Histone Acetylation during Memory Formation in the Hippocampus

Translating the Histone Code

2001 • 9,488 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory

1997 • 1,228 citations

Cellular Memory and the Histone Code

2002 • 1,137 citations

The MAPK cascade is required for mammalian associative learning

1998 • 1,086 citations

Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

1994 • 959 citations

Long-term potentiation in the hippocampus involves activation of N-methyl-D-aspartate receptors

1984 • 905 citations

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

1994 • 889 citations

A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories

2001 • 882 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro

1988 • 800 citations

Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation

2000 • 782 citations

Latent inhibition.

1973 • 774 citations

NF-κB functions in synaptic signaling and behavior

2003 • 672 citations

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

1996 • 662 citations

CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

1995 • 639 citations

The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate GyrusIn Vivo

2000 • 609 citations

Molecular Psychology: Roles for the ERK MAP Kinase Cascade in Memory

2002 • 596 citations

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

1995 • 575 citations

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

1998 • 532 citations

PKCγ mutant mice exhibit mild deficits in spatial and contextual learning

1993 • 532 citations

A Mitogen-Activated Protein Kinase Cascade in the CA1/CA2 Subfield of the Dorsal Hippocampus Is Essential for Long-Term Spatial Memory

1999 • 520 citations

Integration of Long-Term-Memory-Related Synaptic Plasticity Involves Bidirectional Regulation of Gene Expression and Chromatin Structure

2002 • 494 citations

Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

2002 • 454 citations

Increasing the Complexity of Coactivation in Nuclear Receptor Signaling

1999 • 449 citations

Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes

1999 • 388 citations

Impaired Long-Term Memory and NR2A-Type NMDA Receptor-Dependent Synaptic Plasticity in Mice Lacking c-Fos in the CNS

2003 • 371 citations

CREB1 Encodes a Nuclear Activator, a Repressor, and a Cytoplasmic Modulator that Form a Regulatory Unit Critical for Long-Term Facilitation

1998 • 363 citations

Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis

1984 • 346 citations

A Necessity for MAP Kinase Activation in Mammalian Spatial Learning

1999 • 346 citations

Polycomb, Epigenomes, and Control of Cell Identity

2003 • 343 citations

Ischemic Insults Derepress the Gene Silencer REST in Neurons Destined to Die

2003 • 311 citations

Two Time Periods of Hippocampal mRNA Synthesis Are Required for Memory Consolidation of Fear-Motivated Learning

2002 • 295 citations

Positive and negative regulatory mechanisms that mediate long-term memory storage

1998 • 270 citations

Influence of actinomycin D, a RNA synthesis inhibitor, on long‐term potentiation in rat hippocampal neurons in vivo and in vitro.

1996 • 267 citations

Light induces chromatin modification in cells of the mammalian circadian clock

2000 • 259 citations

Altered Histone Acetylation atGlutamate Receptor 2andBrain-Derived Neurotrophic FactorGenes Is an Early Event Triggered by Status Epilepticus

2002 • 258 citations

RNA polymerase II elongation through chromatin

2000 • 244 citations

Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons

2003 • 237 citations

REST Repression of Neuronal Genes Requires Components of the hSWI·SNF Complex

2002 • 180 citations

A Role for the β Isoform of Protein Kinase C in Fear Conditioning

2000 • 179 citations

Fornix-Dependent Induction of Hippocampal CCAAT Enhancer-Binding Protein β and δ Co-Localizes with Phosphorylated cAMP Response Element-Binding Protein and Accompanies Long-Term Memory Consolidation

2001 • 176 citations

A Bioinformatics Analysis of Memory Consolidation Reveals Involvement of the Transcription Factor c-Rel

2004 • 169 citations

Memory in bacteria and phage

2002 • 153 citations

Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues.

1994 • 135 citations

Mitogen-Regulated RSK2-CBP Interaction Controls Their Kinase and Acetylase Activities

2001 • 134 citations

Chromatin-remodeling factors: machines that regulate?

1998 • 127 citations

Chromatin remodeling in development and differentiation

2001 • 126 citations

Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues.

1994 • 112 citations

Phosphorylation of Hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during Contextual Fear Conditioning: Interactions between Erk-1/2 and Elk-1

2002 • 105 citations

Crystal structure of the histone acetyltransferase Hpa2: a tetrameric member of the Gcn5-related N-acetyltransferase superfamily

1999 • 105 citations

Long-term potentiation induced in dendrites separated from rat's CA1 pyramidal somata does not establish a late phase

1989 • 100 citations

p38 MAP Kinase Mediates Both Short-Term and Long-Term Synaptic Depression inAplysia

2003 • 92 citations

Propagating memory of transcriptional states

1995 • 85 citations

A role for COX-2 and p38 mitogen activated protein kinase in long-term depression in the rat dentate gyrus in vitro

2003 • 71 citations