AMPA Receptor Trafficking and Synaptic Plasticity

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

The organization of behavior

1988 • 8,668 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

The organization of behavior.

1950 • 6,879 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

2000 • 2,700 citations

Mechanisms of intracellular protein transport

1994 • 2,280 citations

Activity-dependent scaling of quantal amplitude in neocortical neurons

1998 • 2,213 citations

THE PHYSIOLOGY OF SYNAPSES

1964 • 1,932 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

1995 • 1,342 citations

Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation

1999 • 1,272 citations

The Physiology of Synapses

1964 • 1,239 citations

Evidence for silent synapses: Implications for the expression of LTP

1995 • 1,212 citations

PDZ Domains and the Organization of Supramolecular Complexes

2001 • 1,203 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

1973 • 1,140 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms

2000 • 1,086 citations

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

2000 • 1,085 citations

Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting

2000 • 1,076 citations

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

2001 • 1,073 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Light and electron immunocytochemical localization of AMPA‐selective glutamate receptors in the rat brain

1992 • 988 citations

Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons

2001 • 898 citations

GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors

1997 • 866 citations

A Requirement for the Mitogen-activated Protein Kinase Cascade in Hippocampal Long Term Potentiation

1997 • 866 citations

Ca ²⁺ /calmodulin-kinase II enhances channel conductance of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate type glutamate receptors

1999 • 836 citations

Evidence for multiple AMPA receptor complexes in hippocampal CA1/CA2 neurons

1996 • 835 citations

Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices

1990 • 803 citations

Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit

1996 • 802 citations

Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus

1998 • 798 citations

Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning

1999 • 794 citations

The Tetrameric Structure of a Glutamate Receptor Channel

1998 • 790 citations

Long-term potentiation and functional synapse induction in developing hippocampus

1996 • 787 citations

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

2000 • 728 citations

Interaction with the NMDA receptor locks CaMKII in an active conformation

2001 • 695 citations

Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation

1998 • 693 citations

Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

1999 • 690 citations

Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

2000 • 687 citations

Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68

2000 • 683 citations

An Essential Role for Protein Phosphatases in Hippocampal Long-Term Depression

1993 • 678 citations

Different modes of expression of AMPA and NMDA receptors in hippocampal synapses

1999 • 673 citations

Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

2001 • 657 citations

Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation

1999 • 652 citations

SynGAP: a Synaptic RasGAP that Associates with the PSD-95/SAP90 Protein Family

1998 • 617 citations

Mechanisms Underlying Long-Term Potentiation of Synaptic Transmission

1991 • 615 citations

A Synaptic Ras-GTPase Activating Protein (p135 SynGAP) Inhibited by CaM Kinase II

1998 • 578 citations

Activation of p42 Mitogen-activated Protein Kinase in Hippocampal Long Term Potentiation

1996 • 575 citations

AMPA glutamate receptor subunits are differentially distributed in rat brain

1993 • 574 citations

Role of Actin in Anchoring Postsynaptic Receptors in Cultured Hippocampal Neurons: Differential Attachment of NMDA versus AMPA Receptors

1998 • 557 citations

Maturation of a Central Glutamatergic Synapse

1996 • 551 citations

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

2000 • 550 citations

Phosphorylation of the AMPA Receptor Subunit GluR2 Differentially Regulates Its Interaction with PDZ Domain-Containing Proteins

2000 • 542 citations

NSF Binding to GluR2 Regulates Synaptic Transmission

1998 • 542 citations

Internalization of ionotropic glutamate receptors in response to mGluR activation

2001 • 540 citations

Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1

1999 • 540 citations

Modulation of AMPA receptor unitary conductance by synaptic activity

1998 • 531 citations

Contributions of Quisqualate and NMDA Receptors to the Induction and Expression of LTP

1988 • 512 citations

Silent Synapses during Development of Thalamocortical Inputs

1997 • 502 citations

Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses

1999 • 496 citations

A persistent postsynaptic modification mediates long-term potentiation in the hippocampus

1988 • 496 citations

Enhanced LTP in Mice Deficient in the AMPA Receptor GluR2

1996 • 494 citations

A Model of Synaptic Memory

2001 • 488 citations

Expression of Cerebellar Long-Term Depression Requires Postsynaptic Clathrin-Mediated Endocytosis

2000 • 483 citations

Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation

1989 • 481 citations

Targeting of PKA to Glutamate Receptors through a MAGUK-AKAP Complex

2000 • 463 citations

Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures

1999 • 462 citations

Synaptic activity at calcium-permeable AMPA receptors induces a switch in receptor subtype

2000 • 450 citations

Autophosphorylation-dependent Targeting of Calcium/ Calmodulin-dependent Protein Kinase II by the NR2B Subunit of theN-Methyl-d-aspartate Receptor

1998 • 442 citations

Phosphorylation of the α-Amino-3-hydroxy-5-methylisoxazole4-propionic Acid Receptor GluR1 Subunit by Calcium/ Calmodulin-dependent Kinase II

1997 • 434 citations

Long-term synaptic depression in the mammalian brain

1994 • 432 citations

Postnatal synaptic potentiation: Delivery of GluR4-containing AMPA receptors by spontaneous activity

2000 • 427 citations

Dynamin-dependent endocytosis of ionotropic glutamate receptors

1999 • 425 citations

Postsynaptic Membrane Fusion and Long-Term Potentiation

1998 • 417 citations

SAP97 Is Associated with the α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor GluR1 Subunit

1998 • 415 citations

Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons

1999 • 399 citations

Interaction of the N-Ethylmaleimide–Sensitive Factor with AMPA Receptors

1998 • 396 citations

Identification of the Ca2+/Calmodulin-dependent Protein Kinase II Regulatory Phosphorylation Site in the α-Amino-3-hydroxyl-5-methyl4-isoxazole-propionate-type Glutamate Receptor

1997 • 391 citations

A Role of Actin Filament in Synaptic Transmission and Long-Term Potentiation

1999 • 386 citations

Cerebellar Long-Term Depression Requires PKC-Regulated Interactions between GluR2/3 and PDZ Domain–Containing Proteins

2000 • 381 citations

Calcium/calmodulin-dependent protein kinase II is associated with the N -methyl- <scp>d</scp> -aspartate receptor

1999 • 377 citations

Postsynaptic contribution to long-term potentiation revealed by the analysis of miniature synaptic currents

1992 • 372 citations

Changes in reliability of synaptic function as a mechanism for plasticity

1994 • 367 citations

Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus

2000 • 367 citations

Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression

2001 • 361 citations

The AMPA Receptor GluR2 C Terminus Can Mediate a Reversible, ATP-Dependent Interaction with NSF and α- and β-SNAPs

1998 • 355 citations

Novel Anchorage of GluR2/3 to the Postsynaptic Density by the AMPA Receptor–Binding Protein ABP

1998 • 354 citations

Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors

1998 • 336 citations

Can molecules explain long-term potentiation?

1999 • 333 citations

Mechanism and Regulation of Calcium/Calmodulin-dependent Protein Kinase II Targeting to the NR2B Subunit of the N-Methyl-d-aspartate Receptor

2000 • 332 citations

PDZ Proteins Interacting with C-Terminal GluR2/3 Are Involved in a PKC-Dependent Regulation of AMPA Receptors at Hippocampal Synapses

2000 • 328 citations

Postsynaptic CAMP pathway gates early LTP in hippocampal CA1 region

1995 • 326 citations

PICK1 Targets Activated Protein Kinase Cα to AMPA Receptor Clusters in Spines of Hippocampal Neurons and Reduces Surface Levels of the AMPA-Type Glutamate Receptor Subunit 2

2001 • 322 citations

Mammalian ionotropic glutamate receptors

1993 • 312 citations

Role of Phosphorylation in Regulation of the Assembly of Endocytic Coat Complexes

1998 • 310 citations

Surface Expression of AMPA Receptors in Hippocampal Neurons Is Regulated by an NSF-Dependent Mechanism

1999 • 301 citations

Mutagenesis Reveals a Role for ABP/GRIP Binding to GluR2 in Synaptic Surface Accumulation of the AMPA Receptor

2000 • 295 citations

Regulation of AMPA Receptor GluR1 Subunit Surface Expression by a 4.1N-Linked Actin Cytoskeletal Association

2000 • 295 citations

High-resolution immunogold localization of AMPA type glutamate receptor subunits at synaptic and non-synaptic sites in rat hippocampus

1995 • 292 citations

Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction

1999 • 290 citations

Long-term potentiation is associated with increases in quantal content and quantal amplitude

1992 • 288 citations

Activation of Silent Synapses by Rapid Activity-Dependent Synaptic Recruitment of AMPA Receptors

2001 • 284 citations

Disruption of AMPA receptor GluR2 clusters following long-term depression induction in cerebellar Purkinje neurons

2000 • 272 citations

Phosphorylation of Serine‐880 in GluR2 by Protein Kinase C Prevents Its C Terminus from Binding with Glutamate Receptor‐Interacting Protein

1999 • 260 citations

Synapse-Associated Protein 97 Selectively Associates with a Subset of AMPA Receptors Early in their Biosynthetic Pathway

2001 • 259 citations

Impairment of AMPA Receptor Function in Cerebellar Granule Cells of Ataxic Mutant MouseStargazer

1999 • 253 citations

Characterization of the Glutamate Receptor-Interacting Proteins GRIP1 and GRIP2

1999 • 231 citations

Contribution of cytoskeleton to the internalization of AMPA receptors

2001 • 226 citations

A Developmental Switch in Neurotransmitter Flux Enhances Synaptic Efficacy by Affecting AMPA Receptor Activation

2001 • 226 citations

Bidirectional, Activity-Dependent Regulation of Glutamate Receptors in the Adult Hippocampus In Vivo

2000 • 217 citations

Rapid, Activation-Induced Redistribution of Ionotropic Glutamate Receptors in Cultured Hippocampal Neurons

1999 • 214 citations

The protein kinase Cα binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits

1999 • 209 citations

Biochemical and immunocytochemical characterization of antipeptide antibodies to a cloned GluR1 glutamate receptor subunit: Cellular and subcellular distribution in the rat forebrain

1993 • 190 citations

AMPA receptor–PDZ interactions in facilitation of spinal sensory synapses

1999 • 190 citations

Silent Synapses in the Developing Rat Visual Cortex: Evidence for Postsynaptic Expression of Synaptic Plasticity

1998 • 182 citations

The site of expression of NMDA receptor-dependent LTP: New fuel for an old fire

1995 • 150 citations

Learning Mechanisms: The Case for CaM-KII

1997 • 147 citations

The Calcineurin-Dynamin 1 Complex as a Calcium Sensor for Synaptic Vesicle Endocytosis

1999 • 145 citations

Postsynaptic factors in the expression of long-term potentiation (LTP): increased glutamate receptor binding following LTP induction in vivo.

1993 • 133 citations

Conditional Restoration of Hippocampal Synaptic Potentiation in GluR-A-Deficient Mice

2001 • 128 citations

Long-term potentiation at single fiber inputs to hippocampal CA1 pyramidal cells.

1996 • 109 citations

Involvement of the Secretory Pathway for AMPA Receptors in NMDA-Induced Potentiation in Hippocampus

2001 • 98 citations

A Labile Component of AMPA Receptor-Mediated Synaptic Transmission Is Dependent on Microtubule Motors, Actin, andN-Ethylmaleimide-Sensitive Factor

2001 • 95 citations

Distinct Roles for Ionotropic and Metabotropic Glutamate Receptors in the Maturation of Excitatory Synapses

2000 • 91 citations

Deficiency in induction but not expression of LTP in hippocampal slices from young rats.

1996 • 82 citations

Genes, synapses, and long-term memory

1997 • 82 citations

Calcium-Evoked Dendritic Exocytosis in Cultured Hippocampal Neurons. Part II: Mediation by Calcium/Calmodulin-Dependent Protein Kinase II

1998 • 80 citations

Specificity of molecular changes in neurons involved in memory storage

1990 • 77 citations

Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression

1998 • 67 citations

GluR1-immunopositive interneurons in rat neocortex

1996 • 61 citations

Neurobiology of disease

2000 • 28 citations

rDLG6: A Novel Homolog of Drosophila DLG Expressed in Rat Brain

1999 • 11 citations

A molecular mechanism for the regulated synaptic delivery of GluR4-containing AMPA receptors

2001 • 3 citations