Role of Calcium-Calmodulin–Dependent Protein Kinase II in Modulation of Sensorimotor Synapses inAplysia

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

A Critical Period for Macromolecular Synthesis in Long-Term Heterosynaptic Facilitation in Aplysia

1986 • 767 citations

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

1990 • 741 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones

1982 • 658 citations

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.

1985 • 636 citations

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

1995 • 575 citations

Presynaptic facilitation revisited: state and time dependence

1996 • 555 citations

Spatially Resolved Dynamics of cAMP and Protein Kinase A Subunits in Aplysia Sensory Neurons

1993 • 549 citations

Synaptic Facilitation and Behavioral Sensitization in Aplysia : Possible Role of Serotonin and Cyclic AMP

1976 • 515 citations

The CaM kinase II hypothesis for the storage of synaptic memory

1994 • 510 citations

Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia.

1980 • 380 citations

Serotonin modulates a specific potassium current in the sensory neurons that show presynaptic facilitation in Aplysia.

1982 • 350 citations

cAMP Evokes Long-Term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis

1988 • 265 citations

Phosphorylation-dependent subcellular translocation of a Ca2+/calmodulin-dependent protein kinase produces an autonomous enzyme in Aplysia neurons.

1985 • 261 citations

Target-Dependent Structural Changes Accompanying Long-Term Synaptic Facilitation in Aplysia Neurons

1990 • 230 citations

Facilitatory transmitter causes a selective and prolonged increase in adenosine 3':5'-monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia

1982 • 215 citations

Inhibitor of adenosine 3':5'-monophosphate-dependent protein kinase blocks presynaptic facilitation in Aplysia

1982 • 207 citations

Long-Term Synaptic Facilitation in the Absence of Short-Term Facilitation in Aplysia Neurons

1993 • 197 citations

Role of Transforming Growth Factor-β in Long-Term Synaptic Facilitation in Aplysia

1997 • 189 citations

Inhibitors of protein and RNA synthesis block structural changes that accompany long-term heterosynaptic plasticity in Aplysia

1992 • 181 citations

Second messengers involved in the two processes of presynaptic facilitation that contribute to sensitization and dishabituation in Aplysia sensory neurons.

1990 • 173 citations

Intracellular Injection of cAMP Induces a Long-Term Reduction of Neuronal K ⁺ Currents

1988 • 134 citations

Serotonergic modulation of two potassium currents in the pleural sensory neurons of Aplysia

1989 • 133 citations

The α-Ca2+/calmodulin kinase II: A bidirectional modulator of presynaptic plasticity

1995 • 130 citations

Serotonin produces long-term changes in the excitability of Aplysia sensory neurons in culture that depend on new protein synthesis

1987 • 123 citations

Facilitatory transmitters and cAMP can modulate accommodation as well as transmitter release in Aplysia sensory neurons: Evidence for parallel processing in a single cell

1986 • 119 citations

Membrane responses and changes in cAMP levels in Aplysia sensory neurons produced by serotonin, tryptamine, FMRFamide and small cardioactive peptideB (SCPB)

1985 • 116 citations

Involvement of protein kinase C in serotonin-induced spike broadening and synaptic facilitation in sensorimotor connections of Aplysia

1992 • 112 citations

Concomitant alterations of physiological and developmental plasticity in drosophila CaM kinase II-inhibited synapses

1994 • 105 citations

Sensitizing stimuli cause translocation of protein kinase C in Aplysia sensory neurons.

1990 • 102 citations

Differential effects of cAMP and serotonin on membrane current, action-potential duration, and excitability in somata of pleural sensory neurons of Aplysia

1990 • 102 citations

Roles of second messenger pathways in neuronal plasticity and in learning and memory. Insights gained from Aplysia.

1993 • 101 citations

Pharmacological Dissociation of Modulatory Effects of Serotonin in Aplysia Sensory Neurons

1991 • 96 citations

Modulation of a transient K+ current in the pleural sensory neurons of Aplysia by serotonin and cAMP: implications for spike broadening.

1992 • 90 citations

Serotonin and cyclic adenosine 3':5'-monophosphate modulate the potassium current in tail sensory neurons in the pleural ganglion of Aplysia

1985 • 87 citations

The contributions of protein kinase A and protein kinase C to the actions of 5-HT on the L-type Ca2+ current of the sensory neurons in Aplysia

1993 • 79 citations

Inositol trisphosphate releases intracellularly stored calcium and modulates ion channels in molluscan neurons

1988 • 79 citations

Protein synthesis during acquisition of long-term facilitation is needed for the persistent loss of regulatory subunits of the Aplysia cAMP-dependent protein kinase.

1990 • 76 citations

Selective activation of Ca(2+)-activated PKCs in Aplysia neurons by 5- HT

1992 • 72 citations

Cloning and characterization of two related serotonergic receptors from the brain and the reproductive system of Aplysia that activate phospholipase C

1995 • 66 citations

Differential cyclic AMP dependence of facilitation at Aplysia sensorimotor synapses as a function of prior stimulation: augmentation versus restoration of transmitter release

1993 • 49 citations

Long-term structural remodeling in Aplysia sensory neurons requires de novo protein synthesis during a critical time period

1995 • 41 citations

Activators of protein kinase C mimic serotonin-induced modulation of a voltage-dependent potassium current in pleural sensory neurons of Aplysia

1994 • 38 citations

Reduction of voltage-activated K+ currents by forskolin is not mediated via cAMP in pleural sensory neurons of Aplysia

1990 • 35 citations

Serotonin alters the subcellular distribution of a Ca2+/calmodulin-binding protein in neurons of Aplysia.

1983 • 32 citations

Distribution of cAMP and cAMP-dependent protein kinases in Aplysia sensory neurons

1987 • 31 citations

Effect of a new Ca2(+)-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat.

1990 • 31 citations

Transient versus persistent functional and structural changes associated with facilitation of Aplysia sensorimotor synapses are second messenger dependent

1995 • 30 citations

Neural analogue of long-term sensitization training produces long-term (24 and 48 h) facilitation of the sensory-to-motor neuron connection in Aplysia

1994 • 23 citations

Inositol 1,4,5-trisphosphate alters bursting pacemaker activity in Aplysia neurons: voltage-clamp analysis of effects on calcium currents

1988 • 21 citations

Inositol trisphosphate and activators of protein kinase C modulate membrane currents in tail motor neurons of Aplysia

1989 • 16 citations