The biochemistry of selenoproteins

Superoxide Dismutase

1969 • 12,578 citations

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

1973 • 7,616 citations

Glutathione peroxidase activity in selenium-deficient rat liver

1976 • 3,413 citations

SELENIUM AS AN INTEGRAL PART OF FACTOR 3 AGAINST DIETARY NECROTIC LIVER DEGENERATION

1957 • 1,814 citations

Superoxide Dismutases

1975 • 1,673 citations

Effect of Dietary Selenium on Erythrocyte and Liver Glutathione Peroxidase in the Rat

1974 • 1,205 citations

A SIMPLE PREPARATION OF ADAMANTANE

1957 • 1,151 citations

Glutathione: Metabolism and function

1978 • 971 citations

HEMOGLOBIN CATABOLISM

1957 • 774 citations

Trace Elements in Human Health and Disease

1977 • 753 citations

The Refined Structure of the Selenoenzyme Glutathione Peroxidase at 0.2‐nm Resolution

1983 • 676 citations

Glutathione Peroxidase: The Primary Agent for the Elimination of Hydrogen Peroxide in Erythrocytes^*

1963 • 667 citations

Identification of the catalytic site of rat liver glutathione peroxidase as selenocysteine

1978 • 474 citations

An intracellular GSH-peroxidase with a lipid peroxide substrate

1968 • 450 citations

Selenium deficiency in total parenteral nutrition

1979 • 441 citations

Species, Tissue and Subcellular Distribution of Non Se-Dependent Glutathione Peroxidase Activity

1978 • 399 citations

Posttranslational Covalent Modification of Proteins

1977 • 364 citations

Glutathione peroxidase activity of glutathione-S-transferases purified from rat liver

1977 • 360 citations

Metals as Regulators of Heme Metabolism

1977 • 338 citations

Organic selenium compounds: their chemistry and biology.

1973 • 337 citations

Glutathione Peroxidase, V. The kinetic mechanism

1972 • 337 citations

Comparison of the chemical properties of selenocysteine and selenocystine with their sulfur analogs

1967 • 328 citations

The purification and properties of formate dehydrogenase and nitrate reductase from Escherichia coli.

1975 • 320 citations

Chemical characterization of the selenoprotein component of clostridial glycine reductase: identification of selenocysteine as the organoselenium moiety.

1976 • 301 citations

Selenium-Dependent Enzymes

1980 • 299 citations

Liver Necrosis and Lipid Peroxidation in the Rat as the Result of Paraquat and Diquat Administration

1980 • 284 citations

Purification and properties of NADP-dependent formate dehydrogenase from Clostridium thermoaceticum, a tungsten-selenium-iron protein.

1983 • 268 citations

The need for selenite and molybdate in the formation of formic dehydrogenase by members of the Coli-aerogenes group of bacteria

1954 • 255 citations

Selenocysteine lyase, a novel enzyme that specifically acts on selenocysteine. Mammalian distribution and purification and properties of pig liver enzyme.

1982 • 233 citations

Role of Selenium in the Nutrition of the Chick

1969 • 224 citations

Purification of protein components of the clostridial glycine reductase system and characterization of protein A as a selenoprotein

1973 • 216 citations

A selenocysteine-containing selenium-transport protein in rat plasma

1982 • 196 citations

Organic Selenium Compounds: Their Chemistry and Biology

1974 • 187 citations

Impaired Lipid and Vitamin E Absorption Related to Atrophy of the Pancreas in Selenium-deficient Chicks

1970 • 182 citations

Some Selenium Responses in the Rat not Related to Vitamin E

1969 • 182 citations

Metabolic Aspects of Selenium Action and Toxicity

1976 • 179 citations

Structure, Synthesis and Function of Glutathione Peroxidase

2009 • 178 citations

Effect of Selenium, Vitamin E, and Antioxidants on Testicular Function in Rats12

1973 • 177 citations

Manifestations of chronic selenium deficiency in a child receiving total parenteral nutrition

1983 • 174 citations

Selenium Retention in Tissues and Sperm of Rats Fed α Torula Yeast Diet

1973 • 174 citations

Peroxide removal by selenium-dependent and selenium-independent glutathione peroxidases in hemoglobin-free perfused rat liver.

1978 • 167 citations

Alterations of neutrophil function in selenium-deficient cattle

1979 • 165 citations

WHITE NAILS IN HEPATIC CIRRHOSIS

1954 • 152 citations

Structure analysis and molecular model of the selenoenzyme glutathione peroxidase at 2.8 Å resolution

1979 • 152 citations

Altered lipoxygenase metabolism and decreased glutathione peroxidase activity in platelets from selenium-deficient rats

1980 • 143 citations

A selenium-containing hydrogenase from Methanococcus vannielii. Identification of the selenium moiety as a selenocysteine residue.

1982 • 138 citations

Some characteristics of 75Se-P, a selenoprotein found in rat liver and plasma, and comparison of it with selenoglutathione peroxidase

1982 • 136 citations

Purification and characterization of cytoplasmic thioltransferase (glutathione:disulfide oxidoreductase) from rat liver

1978 • 133 citations

Identification of a major selenium excretory product in rat urine

1969 • 130 citations

Enzymic synthesis of selenocysteine in rat liver

1981 • 128 citations

Evidence that selenium in rat sperm is associated with a cysteine‐rich structural protein of the mitochondrial capsules

1981 • 124 citations

Enzymic Synthesis of Dimethyl Selenide from Sodium Selenite in Mouse Liver Extracts^*

1966 • 119 citations

Biosynthesis of dimethyl selenide from sodium selenite in rat liver and kidney cell-free systems

1977 • 115 citations

Efficacy of Selenium in Selenium Compounds and Feedstuffs for Prevention of Pancreatic Fibrosis in Chicks

1975 • 115 citations

Incorporation of selenium from selenite and selenocystine into glutathione peroxidase in the isolated perfused rat liver

1980 • 106 citations

Defective microbicidal activity in glutathione peroxidase-deficient neutrophils of selenium-deficient rats

1975 • 106 citations

Methionine‐selenomethionine parallels in rat liver polypeptide chain synthesis

1972 • 101 citations

Transmucosal movement of selenium

1965 • 100 citations

Properties of the cadmium and selenium complex formed in rat plasma in vivo and in vitro

1978 • 99 citations

Occurrence of selenocysteine in the selenium-dependent formate dehydrogenase of Methanococcus vannielii

1979 • 96 citations

Selective incorporation of selenium‐75 into a polypeptide of the rat sperm tail

1978 • 93 citations

Are Selenocystine and Selenomethionine Synthesized in Vivo from Sodium Selenite in Mammals?^*

1967 • 93 citations

A Hitherto Unrecognized Factor Against Dietary Necrotic Liver Degeneration in American Yeast (Factor 3)

1951 • 90 citations

Effect of Dietary Methionine on the Biopotency of Selenite and Selenomethionine in the Rat

1981 • 89 citations

The metabolism of 3-methylthiopropionate in rat liver homogenates.

1979 • 85 citations

MUSCULAR DEGENERATION (WHITE STRIATION OF MUSCLES) IN CHICKS REARED ON VITAMIN E DEFICIENT, LOW FAT DIETS

1952 • 77 citations

Federick Charles Pybus.

1975 • 76 citations

The properties of a rat serum protein labelled by the injection of sodium selenite

1977 • 76 citations

Catalytic action of L-methionine .gamma.-lyase on selenomethionine and selenols

1979 • 73 citations

CYSTINE DEFICIENCY IN THE ALBINO RAT

1935 • 72 citations

Influence of Linoleic and Linolenic Acids on Symptoms of Vitamin E Deficiency in Chicks

1958 • 71 citations

Purification and immunohistochemical localization of rat liver glutathione peroxidase

1980 • 70 citations

The isolation and properties of β-galactosidase from Escherichia coli grown on sodium selenate

1967 • 68 citations

Selenocysteine-containing proteins from rat and monkey plasma

1982 • 68 citations

Selenium requirement for active xanthine dehydrogenase from Clostridium acidiurici and Clostridium cylindrosporum

1979 • 66 citations

Some effects of selenium deficiency on the hepatic microsomal cytochrome P-450 system in the rat

1975 • 66 citations

Nicotinic acid hydroxylase fromClostridium barkeri:Selenium-dependent formation of active enzyme

1979 • 66 citations

Selenium proteins in ovine tissues II. Spectral properties of a 10,000 molecular weight selenium protein

1973 • 65 citations

Evidence for the absence of selenocystine and selenomethionine in the serum proteins of chicks administered selenite

1968 • 64 citations

Utilization of Different Forms of Dietary Selenium

1973 • 63 citations

Effects of selenium deficiency on the shape and arrangement of rodent sperm mitochondria

1983 • 63 citations

STUDIES ON THE ENZYMIC REDUCTION OF AMINO ACIDS

1958 • 62 citations

Biochemical changes associated with selenite-induced cataract in the rat

1981 • 61 citations

Selenium-dependent clostridial glycine reductase. Purification and characterization of the two membrane-associated protein components.

1979 • 60 citations

Aminoacylation of Escherichia coli methionine tRNA by selenomethionine

1970 • 58 citations

Urinary Trimethylselenonium Excretion by the Rat: Effect of Level and Source of Selenium-75

1983 • 57 citations

Effects of Selenium Compounds on Formate Metabolism and Coincidence of Selenium-75 Incorporation and Formic Dehydrogenase Activity in Cell-Free Preparations of Escherchia coli

1972 • 56 citations

The cellular localisation of glutathione peroxidase and its release from mitochondria during swelling

1970 • 55 citations

Active transport of L-selenomethionine in the intestine

1967 • 55 citations

Isolation of a selenium-containing thiolase from Clostridium kluyveri: identification of the selenium moiety as selenomethionine.

1982 • 54 citations

Selenium binding proteins in tissues of normal and selenium responsive myopathic lambs

1972 • 53 citations

Selenoamino acids in tissues of rats administered inorganic selenium

1976 • 53 citations

Vitamin B6 Dependence of Selenomethionine and Selenite Utilization for Glutathione Peroxidase in the Rat

1979 • 51 citations

Attachment of selenocysteine in the catalytic site of glutathione peroxidase

1978 • 51 citations

Identification of a selenocysteine-specific aminoacyl transfer RNA from rat liver

1982 • 51 citations

Effects of dietary selenium and tocopherol on glutathione peroxidase and superoxide dismutase activities in rat phagocytes

1976 • 50 citations

Evidence for selenocysteine in ovine tissue organelles

1981 • 48 citations

Selenium proteins in ovine tissues: III distribution of selenium and glutathione peroxidases in tissue cytosols

1978 • 46 citations

Efficiency of Utilization of Indispensable Amino Acids for Growth by the Rat

1972 • 45 citations

Protection against Acute Paraquat Toxicity by Dietary Selenium in the Chick

1983 • 44 citations

In vitro synthesis of glutathione peroxidase from selenite Translational incorporation of selenocysteine

1983 • 42 citations

Selenium and selenoproteins in the rat kidney

1982 • 39 citations

Alimentary Exudative Diathesis, a Consequence of E-avitaminosis

1939 • 35 citations

Amino acid sequence around the active-site selenocysteine of rat liver glutathione peroxidase

1982 • 34 citations

The production of oxygen‐derived radicals by neutrophils from selenium‐deficient cattle

1981 • 29 citations

Effect of Selenium and Vitamin E Deficiency on Nitrofurantoin Toxicity in the Chick

1982 • 28 citations

The Selenium Moiety of Glutathione Peroxidase

1978 • 26 citations

Essential fatty acid metabolism

1975 • 26 citations

Characterization of the selenium in rat liver mitochondria as glutathione peroxidase

1974 • 26 citations

Vitamin E-Selenium Deficiency and Its Influence on Avian Malarial Infection in the Duck

1973 • 19 citations

Defective utilization of haem in selenium-deficient rat liver

1983 • 17 citations

Methionine-Selenomethionine Parallels in E. coli Polypeptide Chain Initiation and Synthesis

1972 • 17 citations

Evidence for an Impairment in the Conversion of Methionine to Cysteine in the Selenium-Deficient Chick

1981 • 16 citations

Biological potency of organic selenium compounds IV. Straight-chain dialkylmono- and diselenides

1974 • 12 citations

Incorporation of Selenium into Liver Glutathione Peroxidase in the Se-Adequate and Se-Deficient Rat

1980 • 12 citations

Keshan Disease

1981 • 12 citations

13 Thiolase

1972 • 12 citations

Biopotency of Selenium for Glutathione Peroxidase Synthesis

1981 • 10 citations

Glutathione-Requiring Enzymes in the Metabolism of Prostaglandin Endoperoxides

1978 • 3 citations