An overview of the relationship between oxidative stress and chemical carcinogenesis

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Oxygen Radicals and Human Disease

1987 • 1,854 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

Chlorination of Taurine by Human Neutrophils

1982 • 794 citations

The Function and Mechanism of Promoters of Carcinogenesis

1973 • 759 citations

Radioprotectors and anticarcinogens

1983 • 613 citations

Biological Reactive Intermediates

1977 • 597 citations

Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound

1981 • 510 citations

Phagocytes as Carcinogens: Malignant Transformation Produced by Human Neutrophils

1985 • 443 citations

AppppA, heat-shock stress, and cell oxidation.

1983 • 379 citations

Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes

1976 • 357 citations

Damage to the Bases in DNA Induced by Hydrogen Peroxide and Ferric Ion Chelates

1989 • 332 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress

1984 • 303 citations

The Role of Oxygen Radicals as a Possible Mechanism of Tumor Promotion

1985 • 282 citations

Peroxyl free radicals: potential mediators of tumor initiation and promotion

1987 • 269 citations

Mutation Caused by Human Phagocytes

1981 • 264 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

DNA Strand Breakage in Human Leukocytes Exposed to a Tumor Promoter, Phorbol Myristate Acetate

1982 • 255 citations

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency.

1975 • 240 citations

An interaction of benzene metabolites reproduces the myelotoxicity observed with benzene exposure

1987 • 239 citations

Antioxidants and multistage carcinogenesis in mouse skin

1989 • 232 citations

The influence of phorbol myristate acetate on oxygen consumption by polymorphonuclear leukocytes.

1974 • 230 citations

Active oxygen acts as a promoter of transformation in mouse embryo C3H/10T1/2/C18 fibroblasts.

1984 • 208 citations

Genetic effects of thymine glycol: site-specific mutagenesis and molecular modeling studies.

1989 • 204 citations

Role of activation of protein kinase C in the stimulation of colonic epithelial proliferation and reactive oxygen formation by bile acids.

1987 • 199 citations

Free radicals in tumor promotion

1986 • 198 citations

Free-Radical Intermediates in the Metabolism of Toxic Chemicals

1982 • 197 citations

Activation of pharmacologic agents to radical intermediates

1982 • 190 citations

Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutants

1978 • 190 citations

Radical formation during the peroxidase catalyzed metabolism of carcinogens and xenobiotics: The reactivity of these radicals with GSH, DNA, and unsaturated lipid

1988 • 163 citations

Role of reactive oxygen in bile salt stimulation of colonic epithelial proliferation.

1986 • 159 citations

Mutation and the environment

1990 • 148 citations

Activation of soluble guanylate cyclase from rat lung by incubation or by hydrogen peroxide.

1976 • 147 citations

Effects of antioxidants on oxidant-induced sister chromatid exchange formation.

1985 • 146 citations

Enhanced malignant progression of mouse skin tumors by the free-radical generator benzoyl peroxide.

1986 • 144 citations

Stimulation of human polymorphonuclear leukocyte superoxide anion radical production by tumor promoters

1981 • 131 citations

ZTP (5-amino 4-imidazole carboxamide riboside 5′-triphosphate): A proposed alarmone for 10-formyl-tetrahydrofolate deficiency

1982 • 121 citations

Oxidant-dependent metabolic activation of polycyclic aromatic hydrocarbons by phorbol ester-stimulated human polymorphonuclear leukocytes: possible link between inflammation and cancer.

1985 • 119 citations

The natural history of carcinogenesis: Implications of experimental carcinogenesis in the genesis of human cancer

1981 • 117 citations

Generation of free radicals from organic hydroperoxide tumor promoters in isolated mouse keratinocytes. Formation of alkyl and alkoxyl radicals from tert-butyl hydroperoxide and cumene hydroperoxide.

1987 • 113 citations

Cancer of the Bladder in Spinal Cord Injury Patients

1981 • 102 citations

Chemical carcinogenesis: a biologic perspective.

1982 • 99 citations

Suppression of tumor promoter-induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism.

1985 • 98 citations

Inhibiton of phorbol ester-stimulated chemiluminescence in human polymorphonuclear leukocytes by retinoic acid and 5,6-epoxyretinoic acid.

1981 • 83 citations

Induction of 5,6-ring-saturated thymine bases in NIH-3T3 cells by phorbol ester-stimulated macrophages: role of reactive oxygen intermediates.

1985 • 82 citations

Peroxidase-mediated irreversible binding of arylamine carcinogens to DNA in intact polymorphonuclear leukocytes activated by a tumor promoter

1985 • 70 citations

Estrogen binding by leukocytes during phagocytosis,.

1977 • 68 citations

Role of inflammatory cells in the metabolic activation of polycyclic aromatic hydrocarbons in mouse skin

1987 • 65 citations

Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters.

1987 • 64 citations

Production of hydrogen peroxide by murine epidermal keratinocytes following treatment with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate.

1990 • 64 citations

Association of DNA strand breaks with accelerated terminal differentiation in mouse epidermal cells exposed to tumor promoters.

1985 • 64 citations

Differential patterns of injury to the proximal tubule of renal cortical slices following in vitro exposure to mercuric chloride, potassium dichromate, or hypoxic conditions*1, *2

1987 • 63 citations

Comparison of the histological changes in the skin of DBA/2 and C57BL/6 mice following exposure to various promoting agents

1987 • 61 citations

12-O-tetradecanoylphorbol-13-acetate-dependent induction of xanthine dehydrogenase and conversion to xanthine oxidase in murine epidermis.

1987 • 60 citations

Inhibition of Ehrlich mouse ascites tumor growth by cordycepin.

1961 • 58 citations

Phagocytosis-induced mutagenesis in bacteria

1983 • 58 citations

Early inflammatory changes in the skin of SENCAR and C57BL/6 mice following exposme to 12-O-tetradecanoylphorbol-13-acetat

1987 • 52 citations

Characterization of the oxidant generation by inflammatory cells lavaged from rat lungs following acute exposure to ozone

1989 • 47 citations

Studies on the interaction of bleomycin A2 with rat lung microsomes. II. Involvement of adventitious iron and reactive oxygen in bleomycin-mediated DNA chain breakage.

1982 • 47 citations

Bioactivation of catechol in rat and human bone marrow cells

1988 • 41 citations

Metabolic activation of eugenol by myeloperoxidase in polymorphonuclear leukocytes

1989 • 36 citations

The Development of Secondary Pathology with free Radical Reactions as a Threshold Mechanism

1983 • 34 citations

Stimulation of superoxide anion formation by the non-TPA type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils

1987 • 30 citations

Augmentation of 1,2-dimethylhydrazine-induced colon cancer by experimental colitis in mice: role of dietary vitamin E.

1986 • 29 citations

Alterations in c-abl gene methylation in cells transformed by phagocyte-generated oxidants

1989 • 27 citations

Comparison of oxidant activities and the activation of benzo(a)pyrene-7,8-dihydrodiol by polymorphonuclear leucocytes from human, rat and mouse

1990 • 26 citations

Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin

1989 • 26 citations

Metabolic activation and nucleic acid binding of acetaminophen and related arylamine substrates by the respiratory burst of human granulocytes

1989 • 25 citations

Enhancement of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced carcinogenesis by urinary tract infection in rats.

1987 • 25 citations

Neutrophil-derived oxidants as mediators of chemical activation in bone marrow

1988 • 23 citations

Metabolic activation of diethylstilbestrol by stimulated human leukocytes

1987 • 19 citations

Activation of bleomycin A2 to a DNA-damaging intermediate by phorbol ester-stimulated human polymorphonuclear leukocytes

1984 • 18 citations

Nucleic acid binding of arylamines during the respiratory burst of human granulocytes

1988 • 18 citations

Induction of sister-chromatid exchanges by polycyclic aromatic hydrocarbons following metabolic activation with phorbol ester-stimulated human polymorphonuclear leukocytes.

1990 • 12 citations

Phospholipase C minics tumor promoter-induced chemiluminescence in murine epidermal cells

1985 • 12 citations

Tumor promoter stimulated irreversible binding of N-methylaminoazobenzene to polynorphonuclear leukocyte DNA

1982 • 11 citations

Further Evidence for the Role of Myeloperoxidase in the Activation of Benzo[A]Pyrene-7,8-Dihydrodiol by Polymorpho-Nuclear Leukocytesm

1991 • 11 citations

[61] Xenobiotic activation by stimulated human polymorphonuclear leukocytes and myeloperoxidase

1990 • 11 citations

Role of free radicals in tumor promotion and progression by benzoyl peroxide.

1990 • 8 citations

U.S.-JAPAN MEETING ON “OXYGEN RADICALS IN CANCER”

1986 • 7 citations

Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C

1989 • 2 citations