Protein kinase C and tumor promoters

Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C

1989 • 1,126 citations

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

1989 • 905 citations

Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties.

1989 • 508 citations

Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain)

1989 • 470 citations

The Family of Protein Kinase C for Signal Transduction

1989 • 383 citations

Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C.

1989 • 318 citations

Association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts.

1989 • 310 citations

Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities

1989 • 259 citations

Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity

1989 • 226 citations

Type 3 protein kinase C localization to the nuclear envelope of phorbol ester-treated NIH 3T3 cells.

1989 • 221 citations

Differential Down-regulation of Protein Kinase C Isozymes

1989 • 219 citations

Biochemical characterization of rat brain protein kinase C isozymes.

1988 • 178 citations

Purification and characterisation of bovine brain protein kinase C isotypes α, β and γ

1989 • 169 citations

Phosphorylation and associated translocation of the 87-kDa protein, a major protein kinase C substrate, in isolated nerve terminals.

1989 • 169 citations

Biosynthesis and Posttranslational Modifications of Protein Kinase C in Human Breast Cancer Cells

1989 • 160 citations

Protein Kinase C Located in Rat Liver Nuclei

1989 • 145 citations

Molecular Genetic Analysis of the Regulatory and Catalytic Domains of Protein Kinase C

1989 • 138 citations

Stimulation of Phosphatidylcholine Hydrolysis, Diacylglycerol Release, and Arachidonic Acid Production by Oncogenic Ras Is a Consequence of Protein Kinase C Activation

1989 • 136 citations

Transcription initiation by RNA polymerase II in vitro. Properties of preinitiation, initiation, and elongation complexes.

1987 • 132 citations

Calcium-Independent Activation of Hypothalamic Type I Protein Kinase C by Unsaturated Fatty Acids

1988 • 120 citations

Lymphoma protein kinase C is associated with the transmembrane glycoprotein, GP85, and may function in GP85-ankyrin binding

1989 • 120 citations

Differential down‐regulation of protein kinase C subspecies in KM3 cells

1988 • 115 citations

The Albert Lasker Medical Awards. The family of protein kinase C for signal transduction

1989 • 111 citations

Scrape-loading of Swiss 3T3 cells with ras protein rapidly activates protein kinase C in the absence of phosphoinositide hydrolysis.

1989 • 103 citations

A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester.

1989 • 102 citations

Phorbol ester-mediated association of protein kinase C to the nuclear fraction in NIH 3T3 cells.

1988 • 99 citations

Complete Activation of Protein Kinase C by an Antipeptide Antibody Directed against the Pseudosubstrate Prototope

1989 • 94 citations

Cells that overproduce protein kinase C are more susceptible to transformation by an activated H-ras oncogene.

1989 • 93 citations

Differences in phorbol-ester-induced down-regulation of protein kinase C between cell lines

1989 • 93 citations

Myristoylated and Nonmyristoylated Forms of a Protein Are Phosphorylated by Protein Kinase C

1989 • 89 citations

p21H-ras-induced morphological transformation and increases in c-myc expression are independent of functional protein kinase C.

1989 • 85 citations

Monoclonal antibodies specific for type 3 protein kinase C recognize distinct domains of protein kinase C and inhibit in vitro functional activity.

1988 • 83 citations

Activation of α-Protein Kinase C Leads to Association with Detergent-Insoluble Components of GH₄C₁Cells

1990 • 79 citations

Immunocytochemical evidence for translocation of protein kinase C in human megakaryoblastic leukemic cells: synergistic effects of Ca2+ and activators of protein kinase C on the plasma membrane association.

1988 • 63 citations

Isolation and characterization of protein kinase C from Y-1 adrenal cell cytoskeleton.

1989 • 63 citations

A protein kinase C pseudosubstrate peptide inhibits phosphorylation of the CD3 antigen in streptolysin-O-permeabilized human T lymphocytes

1989 • 62 citations

Expression of a functional protein kinase C-γ using a baculovirus vector: Purification and characterisation of a single protein kinase C iso-enzyme

1989 • 47 citations

A synthetic peptide analog of the putative substrate‐binding motif activates protein kinase C

1989 • 39 citations

Monoclonal antibodies to protein kinase Cγ

1989 • 31 citations

Differential expression of an 80-kDa protein kinase C substrate in preneoplastic and neoplastic mouse JB6 cells.

1989 • 28 citations

Scrape-loaded p21ras down-regulates agonist-stimulated inositol phosphate production by a mechanism involving protein kinase C

1989 • 17 citations

Monoclonal antibodies against type II rat brain protein kinase C.

1988 • 14 citations