Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein

1994 • 1,802 citations

Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure

1987 • 1,771 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1995 • 1,354 citations

Molecular and Cellular Basis of Addiction

1997 • 1,324 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

Mossy fiber synaptic reorganization in the epileptic human temporal lobe

1989 • 1,150 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

1989 • 1,014 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

A Requirement for Local Protein Synthesis in Neurotrophin-Induced Hippocampal Synaptic Plasticity

1996 • 948 citations

Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

1996 • 943 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity

1988 • 912 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

1994 • 889 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Development of Epileptic Seizures through Brain Stimulation at Low Intensity

1967 • 854 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

1997 • 789 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

Continuous c-fos expression precedes programmed cell death in vivo

1993 • 784 citations

The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain

1990 • 748 citations

A BDNF autocrine loop in adult sensory neurons prevents cell death

1995 • 743 citations

Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system.

1995 • 685 citations

Differential expression of immediate early genes in the hippocampus and spinal cord

1990 • 670 citations

Insulin-like Growth Factor 1 Inhibits Apoptosis Using the Phosphatidylinositol 3′-Kinase and Mitogen-activated Protein Kinase Pathways

1997 • 662 citations

Cellular and molecular basis of epilepsy

1994 • 657 citations

Anoxic-ischemic encephalopathy in rats.

1960 • 644 citations

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

1991 • 636 citations

Brain-derived neurotrophic factor rapidly enhances synaptic transmission in hippocampal neurons via postsynaptic tyrosine kinase receptors.

1995 • 612 citations

Reactive oxygen species are downstream mediators of p53-dependent apoptosis.

1996 • 590 citations

Effects of brain-derived neurotrophic factor on optic axon branching and remodelling in vivo

1995 • 583 citations

Kindling stimulation induces c-fos protein(s) in granule cells of the rat dentate gyrus

1987 • 579 citations

Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs

1992 • 564 citations

The role of neuronal growth factors in neurodegenerative disorders of the human brain

1998 • 539 citations

C/EBP is an immediate-early gene required for the consolidation of long-term facilitation in Aplysia

1994 • 528 citations

The c-Jun transcription factor – bipotential mediator of neuronal death, survival and regeneration

1997 • 520 citations

cAMP contributes to mossy fiber LTP by initiating both a covalently mediated early phase and macromolecular synthesis-dependent late phase

1994 • 501 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation

1997 • 482 citations

Kindling

1978 • 482 citations

Brain Injury Causes a Time-Dependent Increase in Neuronotrophic Activity at the Lesion Site

1982 • 477 citations

Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis

1990 • 408 citations

BDNF, and NT-4/5 enhance glutamatergic synaptic transmission in cultured hippocampal neurones

1994 • 402 citations

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

1994 • 402 citations

DNA damage and apoptosis in Alzheimer's disease: colocalization with c- Jun immunoreactivity, relationship to brain area, and effect of postmortem delay

1996 • 400 citations

A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury

1992 • 381 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

Convulsant-induced increase in transcription factor messenger RNAs in rat brain.

1988 • 377 citations

Seizures produced by pilocarpine in mice: A behavioral, electroencephalographic and morphological analysis

1984 • 368 citations

Electrographic Seizures and New Recurrent Excitatory Circuits in the Dentate Gyrus of Hippocampal Slices from Kainate-Treated Epileptic Rats

1996 • 361 citations

Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss

1995 • 356 citations

Thresholds for synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement

1993 • 345 citations

Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genes

1990 • 332 citations

Brain-Derived Neurotrophic Factor Protects against Ischemic Cell Damage in Rat Hippocampus

1994 • 326 citations

Anticonvulsant and antiepileptogenic actions of MK-801 in the kindling and electroshock models

1988 • 320 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

The induction of LTP increases BDNF and NGF mRNA but decreases NT-3 mRNA in the dentate gyrus

1993 • 313 citations

Correlations between immediate early gene induction and the persistence of long-term potentiation

1993 • 297 citations

Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain

1991 • 295 citations

Insulin-Like Growth Factor and Potassium Depolarization Maintain Neuronal Survival by Distinct Pathways: Possible Involvement of PI 3-Kinase in IGF-1 Signaling

1997 • 294 citations

Electrophysiology of dentate granule cells after kainate-induced synaptic reorganization of the mossy fibers

1992 • 279 citations

Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization

1989 • 275 citations

Suppressed Epileptogenesis in BDNF Mutant Mice

1995 • 272 citations

Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis

1995 • 265 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

Identification of Domains of the Insulin-Like Growth Factor I Receptor That Are Required for Protection from Apoptosis

1997 • 258 citations

Evidence for p53-Mediated Modulation of Neuronal Viability

1996 • 247 citations

The role of immediate early genes in the stabilization of long-term potentiation

1991 • 245 citations

The role of free radicals and p53 in neuron apoptosis in vivo

1995 • 239 citations

Selective expression of Jun proteins following axotomy and axonal transport block in peripheral nerves in the rat: evidence for a role in the regeneration process

1991 • 235 citations

Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease

1993 • 234 citations

Nerve growth factor in Alzheimerʼs disease: defective retrograde transport to nucleus basalis

1995 • 226 citations

Brain-derived neurotrophic factor antisense oligonucleotide impairs memory retention and inhibits long-term potentiation in rats

1997 • 226 citations

Regulation of neuronal Bcl2 protein expression and calcium homeostasis by transforming growth factor type beta confers wide-ranging protection on rat hippocampal neurons.

1994 • 225 citations

Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing

1993 • 223 citations

LTP saturation and spatial learning disruption: effects of task variables and saturation levels

1994 • 218 citations

Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?

1993 • 215 citations

Distribution of Intracerebral Ventricularly Administered Neurotrophins in Rat Brain and Its Correlation with Trk Receptor Expression

1994 • 213 citations

Generalized seizures induce c-fos protein(s) in mammalian neurons

1987 • 212 citations

Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product

1997 • 208 citations

Effects of cycloheximide on delayed neuronal death in rat hippocampus

1990 • 202 citations

Rapid solute transport throughout the brain via paravascular fluid pathways.

1990 • 200 citations

Regulation of neurotrophin and traka, trkb and trkc tyrosine kinase receptor messenger RNA expression in kindling

1993 • 199 citations

Effects of the NMDA receptor/channel antagonists CPP and MK801 on hippocampal field potentials and long-term potentiation in anesthetized rats

1988 • 198 citations

Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain

1994 • 197 citations

Reduction of delayed neuronal death by inhibition of protein synthesis

1990 • 190 citations

Role of the receptors in the development and maintenance of hippocampal kindling in rats

1988 • 190 citations

Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanesthetized rats

1989 • 185 citations

The role of inducible transcription factors in apoptotic nerve cell death

1995 • 184 citations

Characterization of lithium potentiation of pilocarpine-induced status epilepticus in rats

1986 • 181 citations

Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep.

1991 • 180 citations

Epilepsy induced collateral sprouting of hippocampal mossy fibers: Does it induce the development of ectopic synapses with granule cell dendrites?

1993 • 180 citations

Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats

1995 • 179 citations

Anticonvulsant action of a non-competitive antagonist of NMDA receptors (MK-801) in the kindling model of epilepsy

1989 • 179 citations

Hypoxia-ischemia induces transforming growth factor β1 mRNA in the infant rat brain

1992 • 173 citations

Long-term potentiation and kindling: How similar are the mechanisms?

1989 • 172 citations

Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor.

1994 • 172 citations

Chronic electroconvulsive seizure (ECS) treatment results in expression of a long-lasting AP-1 complex in brain with altered composition and characteristics

1994 • 169 citations

p53 Expression Induces Apoptosis in Hippocampal Pyramidal Neuron Cultures

1997 • 169 citations

Correlation between the induction of an immediate early gene,zif/268, and long-term potentiation in the dentate gyrus

1992 • 168 citations

Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat

1990 • 167 citations

Differential Effects of Protein Synthesis Inhibition on the Activity-Dependent Expression of BDNF Transcripts: Evidence for Immediate-Early Gene Responses from Specific Promoters

1996 • 166 citations

Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: Pharmacological characterization

1990 • 165 citations

Brain-derived neurotrophic factor expression after long-term potentiation

1993 • 158 citations

Clozapine and haloperidol produce a differential pattern of immediate early gene expression in rat caudate-putamen, nucleus accumbens, lateral septum and islands of Calleja

1994 • 156 citations

Cortical spreading depression as a putative migraine mechanism

1987 • 155 citations

Status epilepticus may be caused by loss of adenosine anticonvulsant mechanisms

1994 • 154 citations

Molecular mechanisms of opiate and cocaine addiction

1997 • 151 citations

Immediate-early genes, kindling and long-term potentiation

1989 • 146 citations

Bax expression in mammalian neurons undergoing apoptosis, and in Alzheimer's disease hippocampus

1997 • 144 citations

The NMDA-receptor antagonist, MK-801, suppresses limbic kindling and kindled seizures

1988 • 143 citations

Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor

1991 • 136 citations

Dopamine Neurons from Transgenic Mice with a Knockout of the p53 Gene Resist MPTP Neurotoxicity

1996 • 135 citations

Null Mutation of c-fosImpairs Structural and Functional Plasticities in the Kindling Model of Epilepsy

1996 • 135 citations

NMDA Receptor Dependence of Kindling and Mossy Fiber Sprouting: Evidence that the NMDA Receptor Regulates Patterning of Hippocampal Circuits in the Adult Brain

1996 • 133 citations

The NMDA antagonist, MK-801, suppresses long-term potentiation, kindling, and kindling-induced potentiation in the perforant path of the unanesthetized rat

1990 • 132 citations

Perspectives on axonal regeneration in the mammalian CNS

1994 • 126 citations

Nerve Growth Factor Accelerates Seizure Development, Enhances Mossy Fiber Sprouting, and Attenuates Seizure-Induced Decreases in Neuronal Density in the Kindling Model of Epilepsy

1997 • 125 citations

Prolonged expression of AP-1 transcription factors in the rat hippocampus after systemic kainate treatment

1994 • 124 citations

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins.

1996 • 122 citations

Brain-derived neurotrophic factor is induced as an immediate early gene following N-methyl-d-aspartate receptor activation

1993 • 122 citations

p53 Expression in brain after middle cerebral artery occlusion in the rat

1992 • 120 citations

The role of the cyclic AMP-responsive element binding protein (CREB) in hypoxic-ischemic brain damage and repair

1996 • 119 citations

p53‐Knockout Mice Are Protected Against the Long‐Term Effects of Methamphetamine on Dopaminergic Terminals and Cell Bodies

1997 • 119 citations

Involvement of p53 in DNA Strand Break‐induced Apoptosis in Postmitotic CNS Neurons

1996 • 119 citations

Insulin-Like Growth Factor Binding Protein-2 Binds to Cell Surface Proteoglycans in the Rat Brain Olfactory Bulb*

1997 • 118 citations

Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat

1995 • 116 citations

Induction of Fos-like immunoreactivity and the maintenance of long-term potentiation in the dentate gyrus of unanesthetized rats

1990 • 111 citations

Dynamic Changes in the Composition of the AP‐1 Transcription Factor DNA‐binding Activity in Rat Brain Following Kainate‐induced Seizures and Cell Death

1994 • 111 citations

Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation

1996 • 111 citations

Neuronal rescue with transforming growth factor-β1 after hypoxic-ischaemic brain injury

1994 • 110 citations

p53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons

1996 • 107 citations

Atypical and typical neuroleptic treatments induce distinct programs of transcription factor expression in the striatum

1996 • 103 citations

Krox20 may play a key role in the stabilization of long-term potentiation

1995 • 100 citations

Comparison Between the Timing of JNK activation, c‐Jun Phosphorylation, and Onset of Death Commitment in Sympathetic Neurones

1997 • 100 citations

Differential expression of immediate early genes after hippocampal long-term potentiation in awake rats

1993 • 97 citations

Basal expression of Fos, Fos-related, Jun, and Krox 24 proteins in rat hippocampus

1992 • 97 citations

Induction of β-A activin expression by synaptic activity and during neocortical development

1995 • 96 citations

Effects of hypoxia-ischemia and seizures on neuronal and glial-like c-fos protein levels in the infant rat

1990 • 95 citations

Expression of immediate early gene proteins following axotomy and inhibition of axonal transport in the rat central nervous system

1993 • 94 citations

Immediate early gene expression associated with the persistence of heterosynaptic long-term depression in the hippocampus.

1994 • 94 citations

High-frequency discharge of dentate granule cells, but not long-term potentiation, induces c-fos protein

1988 • 93 citations

Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke

1998 • 92 citations

Widespread increase of nerve growth factor protein in the rat forebrain after kindling-induced seizures

1992 • 90 citations

Direct involvement of p53 in programmed cell death of oligodendrocytes.

1995 • 89 citations

Expression of Fos, Jun, and Krox Family Proteins in Alzheimer's Disease

1997 • 88 citations

Differential suppression by protease inhibitors and cytokines of apoptosis induced by wild-type p53 and cytotoxic agents.

1996 • 86 citations

Induction of immediate-early gene proteins in dentate granule cells and somatostatin interneurons after hippocampal seizures

1992 • 85 citations

Antibody to NGF inhibits collateral sprouting of septohippocampal fibers following entorhinal cortex lesion in adult rats

1992 • 85 citations

Neuronal expression of AP-1 proteins in excitotoxic-neurodegenerative disorders and following nerve fiber lesions

1995 • 84 citations

Presence of c-fos-like immunoreactivity in the adult rat brain

1987 • 82 citations

Amygdala kindling and c-fos protein(s)☆

1988 • 81 citations

Increase in activin βA mRNA in rat hippocampus during long‐term potentiation

1996 • 80 citations

Regulation of the transcription factor c-JUN by nerve growth factor in adult sensory neurons

1993 • 77 citations

MK-801, an antagonist of NMDA receptors, inhibits injury-induced c-fos protein accumulation in rat brain

1990 • 77 citations

Insulin-like growth factor II is induced during wound repair following hypoxic-ischemic injury in the developing rat brain

1995 • 77 citations

Sequential patterns of inhibin subunit gene expression following hypoxic-ischemic injury in the rat brain

1996 • 75 citations

Cycloheximide phase-shifts, but does not prevent, de novo Krox-24 protein expression

1997 • 74 citations

Expression of c-Jun Protein in Degenerating Retinal Ganglion Cells after Optic Nerve Lesion in the Rat

1997 • 73 citations

A nerve growth factor peptide retards seizure development and inhibits neuronal sprouting in a rat model of epilepsy.

1995 • 72 citations

Insulin-like growth factor I (IGF-I): A molecular basis for endocrine versus local action?

1991 • 71 citations

Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons

1997 • 70 citations

Increased expression of trkB and trkC messenger RNAS in the rat forebrain after focal mechanical injury

1993 • 70 citations

Insulin-Like Growth Factor-1 Inhibition of Apoptosis Is Associated with Increased Expression of the bcl-xL Gene Product

1997 • 69 citations

Cycloheximide Reduces the Effects of Anoxic InsultIn VivoandIn Vitro

1992 • 67 citations

CREB and memory consolidation

1994 • 66 citations

An apoptotic defect in lens differentiation caused by human p53 is rescued by a mutant allele.

1995 • 65 citations

MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical neurones

1993 • 65 citations

Focal brain injury induces multiple immediate early genes encoding zinc finger transcription factors

1995 • 62 citations

Differential expression of insulin-like growth factor binding proteins (IGFBP) 4 and 5 mRNA in the rat brain after transient hypoxic-ischemic injury

1993 • 62 citations

Muscarinic receptor-mediated induction of Fos protein in rat brain

1993 • 60 citations

Transient c-fos expression accompanies naturally occurring cell death in the developing interhemispheric cortex of the rat

1992 • 60 citations

Expression of insulin-like growth factor-binding protein 2 (IGF-BP 2) following transient hypoxia-ischemia in the infant rat brain

1992 • 60 citations

Mossy fibre sprouting

1997 • 58 citations

Effects of competitive and noncompetitive NMDA receptor antagonists on kindling and LTP

1991 • 58 citations

Intraventricular injection of antiserum to nerve growth factor delays the development of amygdaloid kindling

1988 • 57 citations

Axonal regeneration of sensory nerves is delayed by continuous intrathecal infusion of nerve growth factor

1997 • 56 citations

Induction of Fos in glia-like cells after focal brain injury but not during wallerian degeneration

1990 • 56 citations

Apoptosis, Neurotrophic Factors and Neurodegeneration

1997 • 56 citations

The movement of IGF-I into the brain parenchyma after hypoxic-ischaemic injury

1996 • 56 citations

Annexin V labels apoptotic neurons following hypoxia-ischemia

1997 • 55 citations

Nerve growth factor prevents apoptotic cell death in injured central cholinergic neurons

1995 • 55 citations

Human Activin βA Gene IDENTIFICATION OF NOVEL 5′

1996 • 52 citations

Effect of inhibitors of protein synthesis on the development of kindled seizures in rats

1979 • 51 citations

Induction of Tumor Suppressor p53 and DNA Fragmentation in Organotypic Hippocampal Cultures Following Excitotoxin Treatment

1997 • 50 citations

The effects of insulin-like growth factor (IGF)-1, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats: evidence for a role for IGF binding proteins

1996 • 50 citations

Genetic and activity‐dependent regulation of Zif268 expression: Association with spatial learning

1994 • 48 citations

Two models for determining the mechanisms of damage and repair after hypoxic-ischaemic injury in the developing rat brain

1994 • 47 citations

Selective expression of the immediate early gene c-jun in axotomized rat medial septal neurons is not related to neuronal degeneration

1996 • 47 citations

Hypoxia and hypoxia/ischemia affect the expression of insulin-like growth factor binding protein 2 in the developing rat brain

1993 • 46 citations

Kindling produces long-lasting and selective changes in gene expression of hippocampal neurons.

1993 • 45 citations

TrkB expression in dentate granule cells is associated with a late phase of long-term potentiation

1997 • 45 citations

Photochemical brain injury in rats triggers DNA fragmentation, p53 and HSP72

1994 • 45 citations

Axotomized medial septal-diagonal band neurons express Jun-like immunoreactivity

1992 • 43 citations

Induction of clusterin in the immature brain following a hypoxic-ischemic injury

1996 • 42 citations

A negative correlation between the induction of long-term potentiation and activation of immediate early genes

1991 • 41 citations

The effect of MK‐801 on kindled seizures: Implications for use and limitations as an antiepileptic drug

1989 • 41 citations

Focal brain injury increases activin βA mRNA expression in hippocampal neurons

1997 • 41 citations

Differential regulation by MK801 of immediate-early genes, brain-derived neurotrophic factor and trk receptor mRNA induced by a kindling after-discharge

1998 • 39 citations

Cortical transynaptic activation of tyrosine kinase receptor trkB messenger RNA expression in rat hippocampus

1992 • 38 citations

Neuronal expression of AP-1 proteins in excitotoxic-neurodegenerative disorders and following nerve fiber lesions

1995 • 38 citations

Activation of pirenzepine-sensitive muscarinic receptors induces a specific pattern of immediate-early gene expression in rat brain neurons

1994 • 37 citations

Influence of ketamine on the neuronal death caused by NMDA in the rat hippocampus

1995 • 36 citations

Prostaglandin H synthase-2 and cytosolic phospholipase A2 in the hypoxic-ischemic brain: role in neuronal death or survival?

1997 • 35 citations

p53-deficient mice are protected against adrenalectomy-induced apoptosis

1996 • 35 citations

Medial septal cholinergic neurons express c-Jun but do not undergo DNA fragmentation after fornix-fimbria transections

1996 • 33 citations

Suppression of Spreading Depression of Leão in Neocortex by an N-Methyl-D-Aspartate Receptor Antagonist

1992 • 33 citations

Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis

1997 • 33 citations

Transection of Rat Fimbria-Fornix Induces Lasting Expression of c-Jun Protein in Axotomized Septal Neurons Immunonegative for Choline Acetyltransferase and Nitric Oxide Synthase

1995 • 31 citations

Structure and sequence analysis of the human activin β_Asubunit gene

1991 • 29 citations

Apoptosis mediates cell death following traumatic injury in rat hippocampal neurons

1997 • 29 citations

Differential expression of immediate‐early proteins in non‐nerve cells after focal brain injury

1993 • 27 citations

Insulin-Like Growth Factor Binding Protein-2 Binds to Cell Surface Proteoglycans in the Rat Brain Olfactory Bulb

1997 • 27 citations

Differential expression of inducible transcription factors in basal ganglia neurons

1995 • 26 citations

Ref-1 expression in adult mammalian neurons and astrocytes

1995 • 23 citations

MK-801 sensitizes rats to pilocarpine induced limbic seizures and status epilepticus

1993 • 23 citations

Non-NMDA glutamate receptors are involved in the maintenance of status epilepticus

1993 • 23 citations

The effect of cycloheximide on the regulation of proenkephalin and prodynorphin gene expressions induced by kainic acid in rat hippocampus

1997 • 22 citations

Axotomized septal cholinergic neurons rescued by nerve growth factor or neurotrophin-4/5 fail to express the inducible transcription factor c-Jun

1997 • 21 citations

Accumulation of calcitonin-gene related peptide-like immunoreactivity after hypoxic-ischaemic brain injury in the infant rat

1992 • 21 citations

Cycloheximide, and actinomycin D block the toxic effect of glutamic acid on PC12cells

1994 • 21 citations

Neuroprotective fibroblast growth factor type-2 down-regulates the c-Jun transcription factor in axotomized sympathetic preganglionic neurons of adult rat

1997 • 20 citations

Activation of NMDA and muscarinic receptors induces nur-77 mRNA in hippocampal neurons

1996 • 19 citations

Protein synthesis inhibitors delay transneuronal death in the piriform cortex of young adult rats

1997 • 17 citations

Cloning of rat GADD45 gene and induction analysis following ionizing radiation in vivo

1996 • 15 citations

Seizure-inducible c-fos protein(s) in mammalian neurons

1988 • 13 citations

trkC may be an inducible transcription factor target gene

1995 • 12 citations

MK-801 Does Not Attenuate Immediate-Early Gene Expression Following an Amygdala Afterdischarge

1994 • 11 citations

A fraction enriched in rat hippocampal mossy fibre synaptosomes contains trophic activities

1994 • 2 citations